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Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study

  • Authors:
    • Jiang‑Cun Yang
    • Cui‑Xiang Xu
    • Yang Sun
    • Qian‑Li Dang
    • Ling Li
    • Yong‑Gang Xu
    • Yao‑Jun Song
    • Hong Yan
  • View Affiliations / Copyright

    Affiliations: Department of Transfusion Medicine, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Shaanxi Provincial Center for Clinical Laboratory, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Dermatology, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Laboratory, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Urology, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Epidemiology and Health Statistics, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 37-42
    |
    Published online on: April 30, 2015
       https://doi.org/10.3892/etm.2015.2461
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Abstract

Resuscitation with the early administration of plasma can improve the survival of patients undergoing surgery or trauma patients who require massive transfusion. To ascertain the optimal ratio of fresh frozen plasma (FFP) to packed red blood cells (pRBCs) in massive transfusions, the records of 1,048 patients who received a massive transfusion at 20 hospitals were retrospectively reviewed. The patients were stratified into three groups according to the ratio of FFP to pRBCs. These were the low (<1:2.3), middle (1:2.3‑0.75) and high (≥1:0.75) ratio groups. For 24‑h treatment, the middle FFP:pRBC ratio led to a lower mortality rate (9.31%) compared with that in the low (11.83%) and high (11.44%) ratio groups (P=0.477). For 72‑h treatment, the middle FFP:pRBC ratio also lead to the lowest mortality rate (7.25%), which was significantly lower than the ratios in the low (10.39%) and high (13.65%) ratio groups (P=0.007). The length of hospital stay, ICU stay, and FFP:pRBC ratio in 72 h were found to be significant associated with mortality. The optimal ratio of FFP to pRBCs of 1:2.3‑0.75 in 72 h can improve the survival of patients undergoing massive transfusions.
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Copy and paste a formatted citation
Spandidos Publications style
Yang JC, Xu CX, Sun Y, Dang QL, Li L, Xu YG, Song YJ and Yan H: Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Exp Ther Med 10: 37-42, 2015.
APA
Yang, J., Xu, C., Sun, Y., Dang, Q., Li, L., Xu, Y. ... Yan, H. (2015). Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Experimental and Therapeutic Medicine, 10, 37-42. https://doi.org/10.3892/etm.2015.2461
MLA
Yang, J., Xu, C., Sun, Y., Dang, Q., Li, L., Xu, Y., Song, Y., Yan, H."Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study". Experimental and Therapeutic Medicine 10.1 (2015): 37-42.
Chicago
Yang, J., Xu, C., Sun, Y., Dang, Q., Li, L., Xu, Y., Song, Y., Yan, H."Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study". Experimental and Therapeutic Medicine 10, no. 1 (2015): 37-42. https://doi.org/10.3892/etm.2015.2461
Copy and paste a formatted citation
x
Spandidos Publications style
Yang JC, Xu CX, Sun Y, Dang QL, Li L, Xu YG, Song YJ and Yan H: Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Exp Ther Med 10: 37-42, 2015.
APA
Yang, J., Xu, C., Sun, Y., Dang, Q., Li, L., Xu, Y. ... Yan, H. (2015). Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Experimental and Therapeutic Medicine, 10, 37-42. https://doi.org/10.3892/etm.2015.2461
MLA
Yang, J., Xu, C., Sun, Y., Dang, Q., Li, L., Xu, Y., Song, Y., Yan, H."Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study". Experimental and Therapeutic Medicine 10.1 (2015): 37-42.
Chicago
Yang, J., Xu, C., Sun, Y., Dang, Q., Li, L., Xu, Y., Song, Y., Yan, H."Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study". Experimental and Therapeutic Medicine 10, no. 1 (2015): 37-42. https://doi.org/10.3892/etm.2015.2461
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