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Article

Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines

  • Authors:
    • Xianbin Ning
    • Changfu Zhao
    • Jinfeng Pang
    • Zhaoyi Ding
    • Yubo Wang
    • Kan Xu
    • Hao Chen
    • Bingwei Li
    • Qi Luo
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Affiliated Hospital of Beihua University, Jilin City, Jilin 132011, P.R. China, Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 316-322
    |
    Published online on: May 7, 2015
       https://doi.org/10.3892/etm.2015.2479
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Abstract

The aim of the present study was to evaluate the feasibility of the non-adhesive temperature-sensitive liquid embolic material, chitosan/β‑glycerophosphate (C/GP), in embolizing the basicranial rete mirabile (REM) in a swine model of cerebral arteriovenous malformation (cAVM). A total of 24 domestic swines were used as the experimental animals, among which 12 pigs underwent direct embolization of one side of the REM, while the other 12 pigs underwent embolization of the bilateral REM following anastomosis of the carotid artery and jugular vein. A super‑selective microcatheter was introduced into the REM during the embolization procedure, and the C/GP hydrogel was injected until an image of the REM disappeared in the angiography examination. Further angiography examinations were performed after 2 and 6 weeks, and histological examination of the REM was performed after 6 weeks. Of the 24 domestic swines, 23 cases underwent successful thrombosis. Convulsions occurred in one case and that pig died during the embolization procedure. Following embolization, the angiography observations revealed that the embolized REM was no longer able to be developed, and adhesion of the microcatheter tip with the embolic agent did not occur. In addition, no apparent revascularization was observed in the angiography examinations performed at weeks 2 and 6. Therefore, the current preliminary study indicated that use of the non‑adhesive temperature‑sensitive embolic material was feasible for the embolization of cAVM; thus, C/GP may be used as an ideal embolic material for the treatment of cAVM.
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Copy and paste a formatted citation
Spandidos Publications style
Ning X, Zhao C, Pang J, Ding Z, Wang Y, Xu K, Chen H, Li B and Luo Q: Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines. Exp Ther Med 10: 316-322, 2015.
APA
Ning, X., Zhao, C., Pang, J., Ding, Z., Wang, Y., Xu, K. ... Luo, Q. (2015). Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines. Experimental and Therapeutic Medicine, 10, 316-322. https://doi.org/10.3892/etm.2015.2479
MLA
Ning, X., Zhao, C., Pang, J., Ding, Z., Wang, Y., Xu, K., Chen, H., Li, B., Luo, Q."Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines". Experimental and Therapeutic Medicine 10.1 (2015): 316-322.
Chicago
Ning, X., Zhao, C., Pang, J., Ding, Z., Wang, Y., Xu, K., Chen, H., Li, B., Luo, Q."Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines". Experimental and Therapeutic Medicine 10, no. 1 (2015): 316-322. https://doi.org/10.3892/etm.2015.2479
Copy and paste a formatted citation
x
Spandidos Publications style
Ning X, Zhao C, Pang J, Ding Z, Wang Y, Xu K, Chen H, Li B and Luo Q: Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines. Exp Ther Med 10: 316-322, 2015.
APA
Ning, X., Zhao, C., Pang, J., Ding, Z., Wang, Y., Xu, K. ... Luo, Q. (2015). Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines. Experimental and Therapeutic Medicine, 10, 316-322. https://doi.org/10.3892/etm.2015.2479
MLA
Ning, X., Zhao, C., Pang, J., Ding, Z., Wang, Y., Xu, K., Chen, H., Li, B., Luo, Q."Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines". Experimental and Therapeutic Medicine 10.1 (2015): 316-322.
Chicago
Ning, X., Zhao, C., Pang, J., Ding, Z., Wang, Y., Xu, K., Chen, H., Li, B., Luo, Q."Experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines". Experimental and Therapeutic Medicine 10, no. 1 (2015): 316-322. https://doi.org/10.3892/etm.2015.2479
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