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Article

Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant

  • Authors:
    • Li‑Hua Cao
    • Yun‑Ru Li
    • Shou‑Yun Wang
    • Zhi‑Min Liu
    • Shao‑Chun Sun
    • Dong‑Bo Xu
    • Ji‑Dong Zhang
  • View Affiliations / Copyright

    Affiliations: Liver Disease Center, Qinhuangdao Third Hospital, Qinhuangdao, Hebei 066001, P.R. China, The Affiliated Beijing Ditan Hospital, Capital Medical University, Beijing 100000, P.R. China, Qinhuangdao Women and Children's Hospital, Qinhuangdao, Hebei 066000, P.R. China
  • Pages: 279-284
    |
    Published online on: May 8, 2015
       https://doi.org/10.3892/etm.2015.2483
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Abstract

The aim of the present study was to investigate the effects of vaccination with the hepatitis B vaccine (HBVac) in HB surface antibody (HBsAb)‑negative pregnant mothers on the vertical transmission of HB virus (HBV) from father to infant. All the fathers tested positive for the serum HBV DNA and HB surface antigen (HBsAg) markers. The pregnant females were divided into an observation group or a control group depending on whether their serum was HBsAb‑negative or positive. A total of 93 healthy individuals without HBV infection were included in a blank group, while 96 females who were serum HBV marker‑negative or HB core antibody (HBcAb)‑positive/(HBsAb)‑negative were included in the observation group. The control group comprised 89 females who all tested positive for serum HBsAb, HB envelope antibodies and HBcAb. In the observation group, the positive rate of HBV DNA in the newborns was 7.29% (7/96), the positive rate of HBsAg was 3.13% (3/96) and the positive rate of HBsAb was 81.3% (78/96). In the control group, the positive rates of HBV DNA, HBsAg and HBsAb in the newborns were 4.49% (4/89), 2.25% (2/89) and 89.9% (80/89), respectively. No statistically significant differences were observed between the two groups. Therefore, the results of the present study indicate that HBVac treatment for HBsAb‑negative pregnant females may have a positive role in blocking the vertical transmission of HBV from father to infant, as long as the vaccination is able to induce the production of a sufficient quantity of HBsAb. The HBVac exhibited no difference compared with pre‑pregnancy HBsAb in blocking the vertical transmission of HBV from father to infant.
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Copy and paste a formatted citation
Spandidos Publications style
Cao LH, Li YR, Wang SY, Liu ZM, Sun SC, Xu DB and Zhang JD: Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant. Exp Ther Med 10: 279-284, 2015.
APA
Cao, L., Li, Y., Wang, S., Liu, Z., Sun, S., Xu, D., & Zhang, J. (2015). Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant. Experimental and Therapeutic Medicine, 10, 279-284. https://doi.org/10.3892/etm.2015.2483
MLA
Cao, L., Li, Y., Wang, S., Liu, Z., Sun, S., Xu, D., Zhang, J."Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant". Experimental and Therapeutic Medicine 10.1 (2015): 279-284.
Chicago
Cao, L., Li, Y., Wang, S., Liu, Z., Sun, S., Xu, D., Zhang, J."Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant". Experimental and Therapeutic Medicine 10, no. 1 (2015): 279-284. https://doi.org/10.3892/etm.2015.2483
Copy and paste a formatted citation
x
Spandidos Publications style
Cao LH, Li YR, Wang SY, Liu ZM, Sun SC, Xu DB and Zhang JD: Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant. Exp Ther Med 10: 279-284, 2015.
APA
Cao, L., Li, Y., Wang, S., Liu, Z., Sun, S., Xu, D., & Zhang, J. (2015). Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant. Experimental and Therapeutic Medicine, 10, 279-284. https://doi.org/10.3892/etm.2015.2483
MLA
Cao, L., Li, Y., Wang, S., Liu, Z., Sun, S., Xu, D., Zhang, J."Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant". Experimental and Therapeutic Medicine 10.1 (2015): 279-284.
Chicago
Cao, L., Li, Y., Wang, S., Liu, Z., Sun, S., Xu, D., Zhang, J."Effect of hepatitis B vaccination in hepatitis B surface antibody‑negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant". Experimental and Therapeutic Medicine 10, no. 1 (2015): 279-284. https://doi.org/10.3892/etm.2015.2483
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