Clinicopathological analysis of 12 patients with autoimmune pancreatitis

Zhang,Rui; Shi,Xiang‑De; Zeng,Hong; Cai,Zhao‑Xi; Wu,Wen‑Rui; Yu,Xian‑Huan; Wang,Jie; Liu,Chao

doi:10.3892/etm.2015.2492

July-2015 Volume 10 Issue 1

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July-2015 Volume 10 Issue 1

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Article

Clinicopathological analysis of 12 patients with autoimmune pancreatitis

Authors:
- Rui Zhang
- Xiang‑De Shi
- Hong Zeng
- Zhao‑Xi Cai
- Wen‑Rui Wu
- Xian‑Huan Yu
- Jie Wang
- Chao Liu
View Affiliations / Copyright

Affiliations: Department Hepato‑Pancreato‑Biliary Surgery, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, Guangdong 510120, P.R. China, Department of Pathology, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Radiology, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China
Pages: 121-126
|
Published online on: May 13, 2015

https://doi.org/10.3892/etm.2015.2492
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Abstract

Autoimmune pancreatitis (AIP) is a rare type of chronic pancreatitis that is often misdiagnosed as pancreatic cancer (PaC). This study was undertaken to investigate the clinicopathological characteristics of AIP, in order to improve the diagnosis and treatment of the disease. Among the 271 patients with PaC who underwent pancreatoduodenectomy between January 2003 and December 2012 at the Sun Yat‑Sen Memorial Hospital, chronic pancreatitis was identified and tissue samples obtained from 16 patients. The clinicopathological and imaging characteristics of 16 of the patients with chronic pancreatitis were analyzed retrospectively. The expression of immunoglobulin G4 (IgG4) in the pancreas tissue was detected by immunohistochemistry. Immunohistochemistry showed that IgG4 was highly expressed in 12 out of the 16 patients, and those 12 patients were diagnosed with AIP. Among those 12 patients, 6 presented with emaciation and 7 with jaundice and abdominal pain, respectively. Among the 16 included patients, 12 had an elevated level of serum γ‑glutamyltransferase and 9 had an elevated level of serum carbohydrate antigen 19‑9. The imaging features were as follows: Pancreatic enlargement in 11 patients (particularly pancreatic head enlargement), pancreatic miniature in 1, ‘sausage‑like’ pancreatic changes in 4 and ‘halo’ sign pancreatic changes in 5. Massive plasma cell infiltration (11/12) and parenchymal fibrosis (8/12) were observed in the pancreatic tissues through pathology. These results suggest that combining imaging with IgG4 expression for the purpose of diagnosis can enhance the preoperative diagnostic value and reduce the rate of AIP misdiagnosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinicopathological analysis of 12 patients with autoimmune pancreatitis

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Abstract

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