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Article

Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis

  • Authors:
    • Huaifu Dong
    • Sehua Qu
    • Xin Chen
    • Hongwei Zhu
    • Xiaoyan Tai
    • Jiahua Pan
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Neurology, Anhui Provincial Hospital, Hefei, Anhui 230000, P.R. China
  • Pages: 679-682
    |
    Published online on: May 22, 2015
       https://doi.org/10.3892/etm.2015.2511
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Abstract

The aim of the present study was to investigate the changes in the cytokine expression of peripheral regulatory T cells (Treg) and T helper 17 (Th17) cells in children with rotavirus (RV) enteritis. In total, 102 children with RV enteritis were recruited for the observation group, while 30 healthy cases were included in the control group. Peripheral blood samples were collected from the individuals in the two groups, after which flow cytometry was conducted to detect the proportion of Treg and Th17 cells. In addition, ELISA was used to determine the levels of the cytokines, interleukin (IL)‑10, transforming growth factor (TGF)‑β, IL‑17 and IL‑6. When compared with the control group, the proportion of Treg cells and level of TGF‑β in the peripheral blood of the children with RV enteritis were significantly decreased (P<0.05); however, the proportion of Th17 cells and the serum levels of IL‑17 and IL‑6 in the peripheral blood of children with RV enteritis were significantly increased (P<0.05). In conclusion, the present study identified an imbalance in the proportion of peripheral blood Treg/Th17 cells, and subsequently in the expression of cytokines, in children with RV enteritis. Thus, detecting the proportion of peripheral blood Treg/Th17 cells in children with RV enteritis, or the changes in the levels of serum cytokines, is of clinical significance for further investigation into the pathogenesis of RV enteritis.
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Copy and paste a formatted citation
Spandidos Publications style
Dong H, Qu S, Chen X, Zhu H, Tai X and Pan J: Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis. Exp Ther Med 10: 679-682, 2015.
APA
Dong, H., Qu, S., Chen, X., Zhu, H., Tai, X., & Pan, J. (2015). Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis. Experimental and Therapeutic Medicine, 10, 679-682. https://doi.org/10.3892/etm.2015.2511
MLA
Dong, H., Qu, S., Chen, X., Zhu, H., Tai, X., Pan, J."Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis". Experimental and Therapeutic Medicine 10.2 (2015): 679-682.
Chicago
Dong, H., Qu, S., Chen, X., Zhu, H., Tai, X., Pan, J."Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis". Experimental and Therapeutic Medicine 10, no. 2 (2015): 679-682. https://doi.org/10.3892/etm.2015.2511
Copy and paste a formatted citation
x
Spandidos Publications style
Dong H, Qu S, Chen X, Zhu H, Tai X and Pan J: Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis. Exp Ther Med 10: 679-682, 2015.
APA
Dong, H., Qu, S., Chen, X., Zhu, H., Tai, X., & Pan, J. (2015). Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis. Experimental and Therapeutic Medicine, 10, 679-682. https://doi.org/10.3892/etm.2015.2511
MLA
Dong, H., Qu, S., Chen, X., Zhu, H., Tai, X., Pan, J."Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis". Experimental and Therapeutic Medicine 10.2 (2015): 679-682.
Chicago
Dong, H., Qu, S., Chen, X., Zhu, H., Tai, X., Pan, J."Changes in the cytokine expression of peripheral Treg and Th17 cells in children with rotavirus enteritis". Experimental and Therapeutic Medicine 10, no. 2 (2015): 679-682. https://doi.org/10.3892/etm.2015.2511
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