Expression of glucocorticoid receptor-α in the epidermis of patients with psoriasis vulgaris

Pang,Xiaowen; Zhang,Ping; Zhu,Sainan; Guo,Guangjin

doi:10.3892/etm.2015.2522

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Article Open Access

Expression of glucocorticoid receptor-α in the epidermis of patients with psoriasis vulgaris

Authors:
- Xiaowen Pang
- Ping Zhang
- Sainan Zhu
- Guangjin Guo
View Affiliations / Copyright

Affiliations: Department of Dermatology, Air Force General Hospital of People's Liberation Army, Beijing 100142, P.R. China, Department of Statistics, The First Hospital of Peking University, Beijing 100030, P.R. China

Copyright: © Pang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 419-422
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Published online on: May 26, 2015

https://doi.org/10.3892/etm.2015.2522
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Abstract

Expression of glucocorticoid receptor (GR)-α is observed in almost all tissues and cells of the body; thus, investigating the expression of the receptor in the epidermis of patients with psoriasis vulgaris. The aim of the present study was to investigate GR‑α expression in the epidermis of psoriasis vulgaris patients The study population consisted of 26 patients with psoriasis vulgaris and 10 normal control cases. None of the patients had received any prior treatment with glucocorticoids. Epithelial tissue samples were detected using a streptavidin peroxidation‑enzymatic method for biopsy. Non‑lesional tissue samples from within a range of 3 cm of lesions formed the non‑lesional group, and lesional tissue samples formed the lesional group. Pathological image analysis system (named CMIAS) was used to convert image signals into numeric values, according to the optical density per unit area. GR‑α expression was observed within the nucleus in the normal control group; however, cytoplasmic expression was observed in the lesions of the psoriatic group. The optical density values were significantly lower in the psoriatic group when compared with the normal control group, indicating a statistically significant difference in GR‑α expression between the two groups (P<0.001), and this decreasing correlation was unaffected by the administration of steroids for 6 months. Therefore, decreased expression of GR‑α may play an important role in the degeneration of keratinocytes in patients with psoriasis vulgaris.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of glucocorticoid receptor-α in the epidermis of patients with psoriasis vulgaris

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