Isolated spleen recurrence in a patient with lung adenocarcinoma: A case report

Iguchi,Kesato; Ishibashi,Osamu; Kondo,Tadashi; Kagohashi,Katsunori; Takayashiki,Norio; Satoh,Hiroaki

doi:10.3892/etm.2015.2524

Isolated spleen recurrence in a patient with lung adenocarcinoma: A case report

Authors:
- Kesato Iguchi
- Osamu Ishibashi
- Tadashi Kondo
- Katsunori Kagohashi
- Norio Takayashiki
- Hiroaki Satoh
View Affiliations

Affiliations: Division of Surgery, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, Japan, Division of Pathology, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, Japan
Published online on: May 27, 2015 https://doi.org/10.3892/etm.2015.2524
Pages: 733-736

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Spleen metastasis is extremely rare in patients with lung cancer. However, recent improvements in imaging modalities may enable the antemortem diagnosis of spleen metastasis. The present study reports the case of a female patient with lung adenocarcinoma and spleen metastasis. The patient developed isolated spleen metastasis in the postoperative course. This rare metastasis was detected in a follow‑up abdominal computed tomography (CT) scan without any symptoms, and was confirmed by fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan. Although very rare, chest physicians and thoracic surgeons should be alert to the possibility of spleen metastasis development when evaluating the follow‑up abdominal CT scan. FDG-PET/CT scanning and an interventional approach should be considered to clarify the possibility of spleen metastasis.

View Figures

View References

1	Kraemer BB, Osborne BM and Butler JJ: Primary splenic presentation of malignant lymphoma and related disorders. A study of 49 cases. Cancer. 54:1606–1619. 1984. View Article : Google Scholar : PubMed/NCBI
2	Sharpe RW, Rector JT, Rushin JM, Garvin DF and Cotelingam JD: Splenic metastasis in hairy cell leukemia. Cancer. 71:2222–2226. 1993. View Article : Google Scholar : PubMed/NCBI
3	Auerbach O, Garfinkel L and Parks VR: Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases. Chest. 67:382–387. 1975. View Article : Google Scholar : PubMed/NCBI
4	Densert O and Söderström J: Diffuse metastases in bronchial cancer. Acta Pathol Microbiol Scand. 64:477–484. 1965.PubMed/NCBI
5	Morgenstern L, Rosenberg J and Geller SA: Tumors of the spleen. World J Surg. 9:468–476. 1985. View Article : Google Scholar : PubMed/NCBI
6	Abrams HL, Spiro R and Goldstein N: Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer. 3:74–85. 1950. View Article : Google Scholar : PubMed/NCBI
7	Warren S and Gates O: Lung cancer and metastasis. Arch Pathol. 78:467–473. 1964.PubMed/NCBI
8	Hirst AE Jr and Bullock WK: Metastatic carcinoma of the spleen. Am J Med Sci. 223:414–417. 1952. View Article : Google Scholar : PubMed/NCBI
9	Klein B, Stein M, Kuten A, et al: Splenomegaly and solitary spleen metastasis in solid tumors. Cancer. 60:100–102. 1987. View Article : Google Scholar : PubMed/NCBI
10	Edelman AS and Rotterdam H: Solitary splenic metastasis of an adenocarcinoma of the lung. Am J Clin Pathol. 94:326–328. 1990.PubMed/NCBI
11	Imada H, Nakata H and Horie A: Radiological diagnosis of splenic metastasis and its prevalence at autopsy. Nihon Igaku Hoshasen Gakkai Zasshi. 51:498–503. 1991.(In Japanese). PubMed/NCBI
12	Kinoshita A, Nakano M, Fukuda M, et al: Splenic metastasis from lung cancer. Neth J Med. 47:219–223. 1995. View Article : Google Scholar : PubMed/NCBI
13	Yen RF, Wu YW, Pan MH and Tzen KY: Early detection of splenic metastasis of lung cancer by ¹⁸F-2-fluoro-2-deoxyglucose positron emission tomography. J Formos Med Assoc. 104:674–676. 2005.PubMed/NCBI
14	Fujii M, Tanaka H, Sawazumi T, et al: A case of solitary splenic metastasis following operation for pulmonary pleomorphic carcinoma: Detected at an early stage by FDG-PET. Nihon Kokyuki Gakkai Zasshi. 46:950–954. 2008.(In Japanese). PubMed/NCBI
15	Tang H, Huang H, Xiu Q and Shi Z: Isolated splenic metastasis from lung cancer: Ringleader of continuous fever. Eur Respir Rev. 19:253–256. 2010. View Article : Google Scholar : PubMed/NCBI
16	Soussan M, Pop G, Ouvrier MJ, Neuman A and Weinmann P: Diagnosis of synchronous isolated splenic metastasis from lung adenocarcinoma: Complementary role of FDG PET/CT and diffusion-weighted MRI. Clin Nucl Med. 36:707–709. 2011. View Article : Google Scholar : PubMed/NCBI
17	Sardenberg RA, Pinto C, Bueno CA and Younes RN: Non-small cell lung cancer stage IV long-term survival with isolated spleen metastasis. Ann Thorac Surg. 95:1432–1434. 2013. View Article : Google Scholar : PubMed/NCBI
18	Satoh H, Watanabe K, Ishikawa H, Yamashita YT, Ohtsuka M and Sekizawa K: Splenic metastasis of lung cancer. Oncol Rep. 8:1239–1241. 2001.PubMed/NCBI
19	Scintu F, Carta M, Frau G, Marongiu L, Pipia G and Casula G: Splenic metastases of pulmonary carcinoma. Apropos of a clinical case. Minerva Chir. 46:1277–1280. 1991.(In Italian). PubMed/NCBI
20	Tomaszewski D, Bereza S and Sternau A: Solitary splenic metastases from lung cancer - one-time surgical procedure. Pneumonol Alergol Pol. 71:533–537. 2003.(In Polish). PubMed/NCBI
21	Pramesh CS, Prabhudesai SG, Parasnis AS, Mistry RC and Sharma S: Isolated splenic metastasis from non small cell lung cancer. Ann Thorac Cardiovasc Surg. 10:247–248. 2004.PubMed/NCBI
22	Lachachi F, Abita T, Durand Fontanier S, Maisonnette F and Descottes B: Spontaneous splenic rupture due to splenic metastasis of lung cancer. Ann Chir. 129:521–522. 2004.(In French). View Article : Google Scholar : PubMed/NCBI
23	Schmidt BJ and Smith SL: Isolated splenic metastasis from primary lung adenocarcinoma. South Med J. 97:298–300. 2004. View Article : Google Scholar : PubMed/NCBI
24	Assouline P, Leger-Ravet MB, Paquet JC, et al: Splenic metastasis from a bronchial carcinoma. Rev Mal Respir. 23:265–268. 2006.(In French). View Article : Google Scholar : PubMed/NCBI
25	Sánchez-Romero A, Oliver I, Costa D, et al: Giant splenic metastasis due to lung adenocarcinoma. Clin Transl Oncol. 8:294–295. 2006. View Article : Google Scholar : PubMed/NCBI
26	Van Hul I, Cools P and Rutsaert R: Solitary splenic metastasis of an adenocarcinoma of the lung 2 years postoperatively. Acta Chir Belg. 108:462–463. 2008.PubMed/NCBI
27	Ando K, Kaneko N, Yi L, et al: Splenic metastasis of lung cancer. Nihon Kokyuki Gakkai Zasshi. 47:581–584. 2009.(In Japanese). PubMed/NCBI
28	Chloros D, Bitzikas G, Kakoura M, Chatzikostas G, Makridis C and Tsitouridis I: Solitary splenic metastasis of squamous lung cancer: A case report. Cases J. 2:90912009. View Article : Google Scholar : PubMed/NCBI
29	Dias AR, Pinto RA, Ravanini JN, Lupinacci RM, Cecconello I and Ribeiro U Jr: Isolated splenic metastasis from lung squamous cell carcinoma. World J Surg Oncol. 10:242012. View Article : Google Scholar : PubMed/NCBI
30	Oussama B, Makrem M, Neji FM, et al: Non small cell lung cancer revealed by a solitary splenic metastasis of lung cancer. Tunis Med. 91:484–485. 2013.(In French). PubMed/NCBI
31	Compérat E, Bardier-Dupas A, Camparo P, Capron F and Charlotte F: Splenic metastases: Clinicopathologic presentation, differential diagnosis, and pathogenesis. Arch Pathol Lab Med. 131:965–969. 2007.PubMed/NCBI