Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2015 Volume 10 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 10 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice

  • Authors:
    • Yuanqing Huang
    • Ning Chen
    • Dengshun Miao
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 451-458
    |
    Published online on: May 29, 2015
       https://doi.org/10.3892/etm.2015.2532
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pyrroloquinoline quinone (PQQ) has been demonstrated to function as an antioxidant by scavenging free radicals and subsequently protecting the mitochondria from oxidative stress‑induced damage. The aim of the present study was to investigate whether PQQ is able to rescue premature senescence in the liver, induced by the deletion of B cell‑specific Moloney MLV insertion site‑1 (Bmi‑1), by inhibiting oxidative stress. In vivo, the mice were allocated into three groups that underwent the following treatment protocols. WT mice received a normal diet, while BKO mice also received a normal diet. An additional group of BKO mice were fed a PQQ‑supplemented diet (BKO + PQQ; 4 mg PQQ/kg in the normal diet). The results indicated that PQQ partially rescued the liver damage induced by the deletion of Bmi‑1. PQQ was demonstrated to exhibit these therapeutic effects on liver damage through multiple aspects, including the promotion of proliferation, antiapoptotic effects, the inhibition of senescence, the upregulation of antioxidant ability, the downregulation of cell cycle protein expression, the scavenging of reactive oxygen species and the reduction of DNA damage. The results of these experiments indicated that treatment of BKO mice with a moderate dose of PQQ significantly protected the liver from deleterious effects by inhibiting oxidative stress and participating in DNA damage repair. Therefore, PQQ has great potential as a therapeutic agent against oxidative stress during liver damage.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Fan L, Xu C, Wang C, et al: Bmi1 is required for hepatic progenitor cell expansion and liver tumor development. PLoS One. 7:e464722012. View Article : Google Scholar : PubMed/NCBI

2 

Park MC, Youn HJ, Chang HK, et al: TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl4-induced hepatic damage through the modulation of NF-κB and its regulatory mediators. Food Chem Toxicol. 48:1255–1261. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Srivastava A and Shivanandappa T: Hepatoprotective effect of the root extract of Decalepis hamiltonii against carbon tetrachloride-induced oxidative stress in rats. Food Chem. 118:411–417. 2010. View Article : Google Scholar

4 

Muriel P, Alba N, Pérez-Alvarez VM, et al: Kupffer cells inhibition prevents hepatic lipid peroxidation and damage induced by carbon tetrachloride. Comp Biochem Physiol C Toxicol Pharmacol. 130:219–226. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Harman D: Aging: A theory based on free radical and radiation chemistry. J Gerontol. 11:298–300. 1956. View Article : Google Scholar : PubMed/NCBI

6 

Salmon AB, Richardson A and Pérez VI: Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging. Free Radic Biol Med. 48:642–655. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Park IK, Qian D, Kiel M, et al: Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 423:302–305. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Zhang HW, Ding J, Jin JL, et al: Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. J Bone Miner Res. 25:640–652. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Liu J, Cao L, Chen J, et al: Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 459:387–392. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Hauge JG: Glucose dehydrogenase of bacterium anitratum: An enzyme with a novel prosthetic group. J Biol Chem. 239:3630–3639. 1964.PubMed/NCBI

11 

Duine JA: Cofactor diversity in biological oxidations: Implications and applications. Chem Rec. 1:74–83. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Mitchell AE, Jones AD, Mercer RS and Rucker RB: Characterization of pyrroloquinoline quinone amino acid derivatives by electrospray ionization mass spectrometry and detection in human milk. Anal Biochem. 269:317–325. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Kumazawa T, Sato K, Seno H, et al: Levels of pyrroloquinoline quinone in various foods. Biochem J. 307:331–333. 1995.PubMed/NCBI

14 

Stites TE, Mitchell AE and Rucker RB: Physiological importance of quinoenzymes and the O-quinone family of cofactors. J Nutr. 130:719–727. 2000.PubMed/NCBI

15 

Steinberg FM, Gershwin ME and Rucker RB: Dietary pyrroloquinoline quinone: Growth and immune response in BALB/c mice. J Nutr. 124:744–753. 1994.PubMed/NCBI

16 

Steinberg F, Stites TE, Anderson P, et al: Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets. Exp Biol Med (Maywood). 228:160–166. 2003.PubMed/NCBI

17 

Zhang Y, Feustel PJ and Kimelberg HK: Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat. Brain Res. 1094:200–206. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Zhang Y and Rosenberg PA: The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation. Eur J Neurosci. 16:1015–1024. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Zhu BQ, Simonis U, Cecchini G, et al: Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 11:119–128. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Ohwada K, Takeda H, Yamazaki M, et al: Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats. J Clin Biochem Nutr. 42:29–34. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Shankar BS, Pandey R, Amin P, et al: Role of glutathione in augmenting the anticancer activity of pyrroloquinoline quinone (PQQ). Redox Rep. 15:146–154. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Ouchi A, Nakano M, Nagaoka S and Mukai K: Kinetic study of the antioxidant activity of pyrroloquinolinequinol (PQQH (2), a reduced form of pyrroloquinoline quinone) in micellar solution. J Agric Food Chem. 57:450–456. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Stites T, Storms D, Bauerly K, et al: Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. J Nutr. 136:390–396. 2006.PubMed/NCBI

24 

Ishii T, Akagawa M, Naito Y, et al: Pro-oxidant action of pyrroloquinoline quinone: Characterization of protein oxidative modifications. Biosci Biotechnol Biochem. 74:663–666. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Tao R, Karliner JS, Simonis U, et al: Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 363:257–262. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Misra HS, Khairnar NP, Barik A, et al: Pyrroloquinoline-quinone: A reactive oxygen species scavenger in bacteria. FEBS Lett. 578:26–30. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Cao G, Gu M, Zhu M, et al: Bmi-1 absence causes premature brain degeneration. PLoS One. 7:e320152012. View Article : Google Scholar : PubMed/NCBI

28 

Bauerly K, Harris C, Chowanadisai W, et al: Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. Plos One. 6:e217792011. View Article : Google Scholar : PubMed/NCBI

29 

Xue Y, Karaplis AC, Hendy GN, et al: Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Hum Mol Genet. 14:1515–1528. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Zamzami N, Marchetti P, Castedo M, et al: Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med. 182:367–377. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Bae I, Fan S, Bhatia K, Kohn KW, Fornace AJ Jr and O'Connor PM: Relationships between G1 Arrest and Stability of the p53 and p21CiP1/Waf1 Proteins following gamma-irradiation of human lymphoma cells. Cancer Res. 55:2387–2393. 1995.PubMed/NCBI

32 

Di Pietro C, Piro S, Tabbi G, et al: Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy. Apoptosis. 11:57–66. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Sano R and Reed JC: ER stress-induced cell death mechanisms. Biochim Biophys Acta. 1833:3460–3470. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Tang W, Jiang YF, Ponnusamy M and Diallo M: Role of Nrf2 in chronic liver disease. World J Gastroenterol. 20:13079–13087. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Weltman MD, Farrell GC, Hall P, et al: Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology. 27:128–133. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Okuda M, Li K, Beard MR, et al: Mitochondrial injury, oxidative stress and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology. 122:366–375. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Salisbury SA, Forrest HS, Cruse WB and Kennard O: A novel coenzyme from bacterial primary alcohol dehydrogenases. Nature. 280:843–844. 1979. View Article : Google Scholar : PubMed/NCBI

38 

Rucker R, Chowanadisai W and Nakano M: Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 14:268–277. 2009.PubMed/NCBI

39 

Killgore J, Smidt C, Duich L, et al: Nutritional importance of pyrroloquinoline quinone. Science. 245:850–852. 1989. View Article : Google Scholar : PubMed/NCBI

40 

Bishop A, Paz MA, Gallop PM, et al: Methoxatin PQQ in guinea-pig neutrophils. Free Radic Biol Med. 17:311–320. 1994. View Article : Google Scholar : PubMed/NCBI

41 

He K, Nukada H, Urakami T and Murphy MP: Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): Implications for its function in biological systems. Biochem Pharmacol. 65:67–74. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Zhu B, Zhou H, Teerlink JR, et al: Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion. Cardiovasc Drugs Ther. 18:421–431. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Aizenman E, Hartnett KA, Zhong C, et al: Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site. J Neurosci. 12:2362–2369. 1992.PubMed/NCBI

44 

Kumar N, Kar A and Panda S: Pyrroloquinoline quinone ameliorates l-thyroxine-induced hyperthyroidism and associated problems in rats. Cell Biochem Funct. 32:538–546. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Jin J, Lv X, Chen L, Zhang W, Li J, Wang Q, Wang R, Lu X and Miao D: Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance. Aging Cell. 13:797–809. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Chen N and Miao D: Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. Exp Ther Med 10: 451-458, 2015.
APA
Huang, Y., Chen, N., & Miao, D. (2015). Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. Experimental and Therapeutic Medicine, 10, 451-458. https://doi.org/10.3892/etm.2015.2532
MLA
Huang, Y., Chen, N., Miao, D."Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice". Experimental and Therapeutic Medicine 10.2 (2015): 451-458.
Chicago
Huang, Y., Chen, N., Miao, D."Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice". Experimental and Therapeutic Medicine 10, no. 2 (2015): 451-458. https://doi.org/10.3892/etm.2015.2532
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Chen N and Miao D: Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. Exp Ther Med 10: 451-458, 2015.
APA
Huang, Y., Chen, N., & Miao, D. (2015). Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. Experimental and Therapeutic Medicine, 10, 451-458. https://doi.org/10.3892/etm.2015.2532
MLA
Huang, Y., Chen, N., Miao, D."Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice". Experimental and Therapeutic Medicine 10.2 (2015): 451-458.
Chicago
Huang, Y., Chen, N., Miao, D."Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice". Experimental and Therapeutic Medicine 10, no. 2 (2015): 451-458. https://doi.org/10.3892/etm.2015.2532
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team