Open Access

Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice

  • Authors:
    • Yuanqing Huang
    • Ning Chen
    • Dengshun Miao
  • View Affiliations

  • Published online on: May 29, 2015     https://doi.org/10.3892/etm.2015.2532
  • Pages: 451-458
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pyrroloquinoline quinone (PQQ) has been demonstrated to function as an antioxidant by scavenging free radicals and subsequently protecting the mitochondria from oxidative stress‑induced damage. The aim of the present study was to investigate whether PQQ is able to rescue premature senescence in the liver, induced by the deletion of B cell‑specific Moloney MLV insertion site‑1 (Bmi‑1), by inhibiting oxidative stress. In vivo, the mice were allocated into three groups that underwent the following treatment protocols. WT mice received a normal diet, while BKO mice also received a normal diet. An additional group of BKO mice were fed a PQQ‑supplemented diet (BKO + PQQ; 4 mg PQQ/kg in the normal diet). The results indicated that PQQ partially rescued the liver damage induced by the deletion of Bmi‑1. PQQ was demonstrated to exhibit these therapeutic effects on liver damage through multiple aspects, including the promotion of proliferation, antiapoptotic effects, the inhibition of senescence, the upregulation of antioxidant ability, the downregulation of cell cycle protein expression, the scavenging of reactive oxygen species and the reduction of DNA damage. The results of these experiments indicated that treatment of BKO mice with a moderate dose of PQQ significantly protected the liver from deleterious effects by inhibiting oxidative stress and participating in DNA damage repair. Therefore, PQQ has great potential as a therapeutic agent against oxidative stress during liver damage.
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August 2015
Volume 10 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Huang, Y., Chen, N., & Miao, D. (2015). Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. Experimental and Therapeutic Medicine, 10, 451-458. https://doi.org/10.3892/etm.2015.2532
MLA
Huang, Y., Chen, N., Miao, D."Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice". Experimental and Therapeutic Medicine 10.2 (2015): 451-458.
Chicago
Huang, Y., Chen, N., Miao, D."Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice". Experimental and Therapeutic Medicine 10, no. 2 (2015): 451-458. https://doi.org/10.3892/etm.2015.2532