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Article

Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males

  • Authors:
    • Naobumi Hamadate
    • Yoshiyuki Matsumoto
    • Kayoko Seto
    • Tetsuro Yamamoto
    • Hideyo Yamaguchi
    • Takashi Nakagawa
    • Etsushi Yamamoto
    • Mitsuhiko Fukagawa
    • Kazunaga Yazawa
  • View Affiliations / Copyright

    Affiliations: Department of Research and Development, Egao Co., Ltd., Kumamoto 862-0902, Japan, Research Center, TTC Co., Ltd., Shibuya‑ku, Tokyo 113-0021, Japan, Shinyokohama Shinoharaguchi Orthopaedic Surgery/Dermatology Clinic, Yokohama, Kanagawa 222-0026, Japan, Laboratory of Nutraceuticals and Functional Foods Science, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
  • Pages: 641-646
    |
    Published online on: June 11, 2015
       https://doi.org/10.3892/etm.2015.2568
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Abstract

Shark liver oil (SLO) has long been used as a traditional health food, with a particular benefit for vascular health, in Japan. The aim of this study was to assess the effect of dietary supplementation with SLO on arterial stiffness and peripheral microvascular function in otherwise healthy middle‑aged and older males with slightly increased arterial stiffness. A randomized, double‑blind, placebo‑controlled, parallel study design was used to assign 41 healthy males with a mean age of 59.0±4.0 years (range, 45‑69 years) to either SLO (n=21) or placebo (n=20) treatment for eight weeks. The effects on arterial stiffness and peripheral microvascular function were assessed by the cardio‑ankle vascular index (CAVI) and by measurement of hand blood flow to cutaneous tissues using a laser Doppler perfusion imaging (LDPI) technique, respectively. Although the magnitude of the changes in the CAVI value during the eight‑week intervention for the SLO group did not significantly differ from that for the placebo group, the changes in the CAVI value for the former group were significantly associated (r=0.575, P<0.01) with age. It was also found that the LDPI values at week 8 were significantly lowered (P<0.05) compared with the baseline values in the placebo group, while no change was observed in the SLO group, resulting in a significant difference in the changes between the two groups (P=0.002). Neither SLO supplementation‑related adverse side‑effects nor any abnormal changes in routine laboratory tests, including lipid profiles and anthropometric and haemodynamic parameters, were observed throughout the intervention. SLO may have the potential to safely improve vascular health in middle‑aged and elderly males.
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Copy and paste a formatted citation
Spandidos Publications style
Hamadate N, Matsumoto Y, Seto K, Yamamoto T, Yamaguchi H, Nakagawa T, Yamamoto E, Fukagawa M and Yazawa K: Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males. Exp Ther Med 10: 641-646, 2015.
APA
Hamadate, N., Matsumoto, Y., Seto, K., Yamamoto, T., Yamaguchi, H., Nakagawa, T. ... Yazawa, K. (2015). Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males. Experimental and Therapeutic Medicine, 10, 641-646. https://doi.org/10.3892/etm.2015.2568
MLA
Hamadate, N., Matsumoto, Y., Seto, K., Yamamoto, T., Yamaguchi, H., Nakagawa, T., Yamamoto, E., Fukagawa, M., Yazawa, K."Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males". Experimental and Therapeutic Medicine 10.2 (2015): 641-646.
Chicago
Hamadate, N., Matsumoto, Y., Seto, K., Yamamoto, T., Yamaguchi, H., Nakagawa, T., Yamamoto, E., Fukagawa, M., Yazawa, K."Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males". Experimental and Therapeutic Medicine 10, no. 2 (2015): 641-646. https://doi.org/10.3892/etm.2015.2568
Copy and paste a formatted citation
x
Spandidos Publications style
Hamadate N, Matsumoto Y, Seto K, Yamamoto T, Yamaguchi H, Nakagawa T, Yamamoto E, Fukagawa M and Yazawa K: Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males. Exp Ther Med 10: 641-646, 2015.
APA
Hamadate, N., Matsumoto, Y., Seto, K., Yamamoto, T., Yamaguchi, H., Nakagawa, T. ... Yazawa, K. (2015). Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males. Experimental and Therapeutic Medicine, 10, 641-646. https://doi.org/10.3892/etm.2015.2568
MLA
Hamadate, N., Matsumoto, Y., Seto, K., Yamamoto, T., Yamaguchi, H., Nakagawa, T., Yamamoto, E., Fukagawa, M., Yazawa, K."Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males". Experimental and Therapeutic Medicine 10.2 (2015): 641-646.
Chicago
Hamadate, N., Matsumoto, Y., Seto, K., Yamamoto, T., Yamaguchi, H., Nakagawa, T., Yamamoto, E., Fukagawa, M., Yazawa, K."Vascular effects and safety of supplementation with shark liver oil in middle‑aged and elderly males". Experimental and Therapeutic Medicine 10, no. 2 (2015): 641-646. https://doi.org/10.3892/etm.2015.2568
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