Chemoembolization and stenting combined with iodine-125 seed strands for the treatment of hepatocellular carcinoma with inferior vena cava obstruction

Li,Wenhui; Dai,Zhenyu; Yao,Lizheng; Luo,Jianjun; Yan,Zhiping

doi:10.3892/etm.2015.2581

September-2015 Volume 10 Issue 3

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September-2015 Volume 10 Issue 3

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Article

Chemoembolization and stenting combined with iodine-125 seed strands for the treatment of hepatocellular carcinoma with inferior vena cava obstruction

Authors:
- Wenhui Li
- Zhenyu Dai
- Lizheng Yao
- Jianjun Luo
- Zhiping Yan
View Affiliations / Copyright

Affiliations: Department of Interventional Radiology, Yancheng Hospital, Dongnan University, Yancheng, Jiangsu 224001, P.R. China, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
Pages: 973-977
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Published online on: June 18, 2015

https://doi.org/10.3892/etm.2015.2581
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Abstract

The aim of the present study was to investigate the efficacy and safety of stenting combined with radioactive iodine‑125 seed strands following chemoembolization for the treatment of patients with hepatocellular carcinoma and inferior vena cava (IVC) obstruction. A retrospective analysis was conducted of 52 hepatocellular carcinoma patients with IVC obstruction. All patients received chemoembolization of tumor‑supplying arteries and IVC stents, and 18 patients additionally received iodine‑125 seed strands, which were fixed to the stents. Improvement of IVC obstruction and the tumor response rates were compared between the two groups with a median follow‑up time of 2.5 months. In both groups the stents were successfully deployed. At the 2‑month post‑procedural follow‑up, the mean diameter of the IVC obstruction site, the mean pressure difference between the distal IVC obstructive segment and the right atrium as well as the obstruction scoring did not differ significantly between the two groups. By contrast, the tumor response rate of the iodine‑125 seed strand group was 94.4%, whereas for the group without iodine‑125 seed strands it was 35.3% (P<0.001). The combination of stent and iodine‑125 seed strands was effective and safe for the treatment of hepatocellular carcinoma with IVC obstruction.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Chemoembolization and stenting combined with iodine-125 seed strands for the treatment of hepatocellular carcinoma with inferior vena cava obstruction

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