Adult systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease: A case report
- Authors:
- Youping Wang
- Xinyue Liu
- Yan Chen
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Affiliations: Department of Oncology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China, Department of Hematology, The Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
- Published online on: June 29, 2015 https://doi.org/10.3892/etm.2015.2601
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Pages:
1025-1028
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Abstract
Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (EBV+ T-LPD) occurs mainly in Asia and South America and is extremely rare in adults. The disease is characterized by a clonal proliferation of EBV-infected T cells with a cytotoxic immunophenotype and is associated with a poor clinical outcome and can be life‑threatening. The majority of the patients have evidence of systemic disease, often with lymph node, liver and spleen involvement. The present study describes a case of adult systemic EBV+ T‑LPD with high fever, systemic lymphadenopathy, hepatosplenomegaly, nose-pharynx neoplasm, pancytopenia, EB virus infection and proliferative bone marrow, with the aim of improving the understanding of the condition.
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