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Article

Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris

  • Authors:
    • Xiangqi Chen
    • Hongtao Song
    • Shengping Chen
    • Jing Zhang
    • Gaoxiang Niu
    • Xiangnong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Fuzhou General Hospital, Fuzhou Medical College, Second Military Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Pharmacy, Fuzhou General Hospital, Fuzhou Medical College, Second Military Medical University, Fuzhou, Fujian 350025, P.R. China
  • Pages: 1194-1198
    |
    Published online on: July 15, 2015
       https://doi.org/10.3892/etm.2015.2638
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Abstract

Acne vulgaris is considered as a therapeutic challenge in terms of managing ongoing symptoms and preventing scar formation. Although there are many available treatments for alleviating acne, therapies for resistant or moderate‑to‑severe forms have been limited to systemic agents that are accompanied by potentially severe side‑effects. While, aminolevulinic acid (ALA) photodynamic therapy (PDT) has increasingly been used as a simple and safe therapeutic option of acne vulgaris, the clinical efficacy requires confirmation in further studies. The aim of this study was to investigate the efficacy and safety of 5‑ALA‑PDT in the treatment of moderate‑to‑severe facial acne vulgaris. A total of 50 patients with moderate‑to‑severe facial acne were enrolled in the study and randomly divided equally into a therapy group and a control group. In the therapy group, the patients were treated with 5% 5‑ALA for 1.5 h, followed by three 20‑min doses of infrared radiation once a week; in the control group, the patients were treated with three 20 min doses of infrared radiation without 5‑ALA once a week. Both treatments lasted for 3 weeks. The clinical efficacy was determined by evaluating acne lesion counts at weeks 0, 2, 4 and 6. Total efficacy rate (TER) was the primary endpoint of the study, and was defined as the proportion of the patients whose treatment effectiveness evaluation was cured (≥90% of skin lesions improved) and excellent (60‑89% improvement). Adverse effects were recorded throughout the study. The study was completed by 24 patients in the therapy group and 23 patients in the control group. The numbers of acne lesions significantly decreased. The TER of the therapy group was significantly higher than that of the control group at weeks 4 and 6. Adverse effects were observed in 12 patients of the therapy group and 2 patients of the control group. In the therapy group the most common adverse effect was a burning sensation (n=7), followed by transient hyperpigmentation (n=3) and acute acneform lesions (n=2), while in control group, the 2 patients experienced flushing and dryness. The adverse effects were all cured by a symptomatic approach prior to the end of the study. 5‑ALA‑PDT combined with infrared radiation is an effective and safe therapy for moderate-to-severe facial acne.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Song H, Chen S, Zhang J, Niu G and Liu X: Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris. Exp Ther Med 10: 1194-1198, 2015.
APA
Chen, X., Song, H., Chen, S., Zhang, J., Niu, G., & Liu, X. (2015). Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris. Experimental and Therapeutic Medicine, 10, 1194-1198. https://doi.org/10.3892/etm.2015.2638
MLA
Chen, X., Song, H., Chen, S., Zhang, J., Niu, G., Liu, X."Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris". Experimental and Therapeutic Medicine 10.3 (2015): 1194-1198.
Chicago
Chen, X., Song, H., Chen, S., Zhang, J., Niu, G., Liu, X."Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1194-1198. https://doi.org/10.3892/etm.2015.2638
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Song H, Chen S, Zhang J, Niu G and Liu X: Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris. Exp Ther Med 10: 1194-1198, 2015.
APA
Chen, X., Song, H., Chen, S., Zhang, J., Niu, G., & Liu, X. (2015). Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris. Experimental and Therapeutic Medicine, 10, 1194-1198. https://doi.org/10.3892/etm.2015.2638
MLA
Chen, X., Song, H., Chen, S., Zhang, J., Niu, G., Liu, X."Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris". Experimental and Therapeutic Medicine 10.3 (2015): 1194-1198.
Chicago
Chen, X., Song, H., Chen, S., Zhang, J., Niu, G., Liu, X."Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1194-1198. https://doi.org/10.3892/etm.2015.2638
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