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Article

Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer

  • Authors:
    • Qiang Jia
    • Zhaowei Meng
    • Jian Tan
    • Guizhi Zhang
    • Yajing He
    • Haoran Sun
    • Chunshui Yu
    • Dong Li
    • Wei Zheng
    • Renfei Wang
    • Shen Wang
    • Xue Li
    • Jianping Zhang
    • Tianpeng Hu
    • Na Liu
    • Arun Upadhyaya
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Heping, Tianjin 300052, P.R. China, Department of Radiology, Tianjin Medical University General Hospital, Heping, Tianjin 300052, P.R. China
  • Pages: 1995-2001
    |
    Published online on: September 11, 2015
       https://doi.org/10.3892/etm.2015.2744
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Abstract

Iodine-131 (I-131) therapy and post-therapy I-131 scanning are essential in the management of differentiated thyroid cancer (DTC). However, pathological false positive I‑131 scans can lead to misdiagnosis and inappropriate I‑131 treatment. This retrospective study aimed to investigate the best imaging modality for the diagnosis of pathological false positive I‑131 scans in a DTC patient cohort, and to determine its incidence. DTC patient data archived from January 2008 to January 2010 was retrieved. Post‑therapeutic I‑131 scans were conducted and interpreted. The imaging modalities of magnetic resonance imaging (MRI), computed tomography and ultrasonography were applied and compared to check all suspected lesions. Biopsy or needle aspiration was conducted for patients who consented to the acquisition of histopathological confirmation. Data for 156 DTC patients were retrieved. Only 6 cases of pathological false‑positives were found among these (incidence, 3.85%), which included 3 cases of thymic hyperplasia in the mediastinum, 1 case of pleomorphic adenoma in the parapharyngeal space and 1 case of thyroglossal duct cyst in the neck. MRI was demonstrated as the best imaging modality for diagnosis due to its superior soft tissue resolution. However, no imaging modality was able to identify the abdominal false positive‑lesions observed in 2 cases, one of whom also had thymic hyperplasia. In conclusion, pathological false positive I-131 scans occurred with an incidence of 3.85%. MRI was the best imaging modality for diagnosing these pathological false-positives.
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Copy and paste a formatted citation
Spandidos Publications style
Jia Q, Meng Z, Tan J, Zhang G, He Y, Sun H, Yu C, Li D, Zheng W, Wang R, Wang R, et al: Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer. Exp Ther Med 10: 1995-2001, 2015.
APA
Jia, Q., Meng, Z., Tan, J., Zhang, G., He, Y., Sun, H. ... Upadhyaya, A. (2015). Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer. Experimental and Therapeutic Medicine, 10, 1995-2001. https://doi.org/10.3892/etm.2015.2744
MLA
Jia, Q., Meng, Z., Tan, J., Zhang, G., He, Y., Sun, H., Yu, C., Li, D., Zheng, W., Wang, R., Wang, S., Li, X., Zhang, J., Hu, T., Liu, N., Upadhyaya, A."Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer". Experimental and Therapeutic Medicine 10.5 (2015): 1995-2001.
Chicago
Jia, Q., Meng, Z., Tan, J., Zhang, G., He, Y., Sun, H., Yu, C., Li, D., Zheng, W., Wang, R., Wang, S., Li, X., Zhang, J., Hu, T., Liu, N., Upadhyaya, A."Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1995-2001. https://doi.org/10.3892/etm.2015.2744
Copy and paste a formatted citation
x
Spandidos Publications style
Jia Q, Meng Z, Tan J, Zhang G, He Y, Sun H, Yu C, Li D, Zheng W, Wang R, Wang R, et al: Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer. Exp Ther Med 10: 1995-2001, 2015.
APA
Jia, Q., Meng, Z., Tan, J., Zhang, G., He, Y., Sun, H. ... Upadhyaya, A. (2015). Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer. Experimental and Therapeutic Medicine, 10, 1995-2001. https://doi.org/10.3892/etm.2015.2744
MLA
Jia, Q., Meng, Z., Tan, J., Zhang, G., He, Y., Sun, H., Yu, C., Li, D., Zheng, W., Wang, R., Wang, S., Li, X., Zhang, J., Hu, T., Liu, N., Upadhyaya, A."Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer". Experimental and Therapeutic Medicine 10.5 (2015): 1995-2001.
Chicago
Jia, Q., Meng, Z., Tan, J., Zhang, G., He, Y., Sun, H., Yu, C., Li, D., Zheng, W., Wang, R., Wang, S., Li, X., Zhang, J., Hu, T., Liu, N., Upadhyaya, A."Retrospective imaging study on the diagnosis of pathological false positive iodine-131 scans in patients with thyroid cancer". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1995-2001. https://doi.org/10.3892/etm.2015.2744
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