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Article

Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions

  • Authors:
    • Yaping Wang
    • Zhen Zhao
    • Yingzhong Yang
    • Yanxia Zhao
    • Ri‑Li Ge
  • View Affiliations / Copyright

    Affiliations: Department of Digestion, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, P.R. China, Research Center for High Altitude Medicine, Medical College of Qinghai University, Xining, Qinghai 810001, P.R. China
  • Pages: 1877-1882
    |
    Published online on: September 18, 2015
       https://doi.org/10.3892/etm.2015.2754
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Abstract

The main purpose of the present study was to investigate the change in thymocyte telomere length of rats exposed to different hypoxic conditions for different periods of time, as well as its effect on the immune system. A total of 110 male Wistar rats were randomly assigned to one of the three following groups: i) Sea level (SL) group, in which 10 rats were maintained at an altitude of 10 m; ii) moderate altitude (MA) group, in which 50 rats were maintained at an altitude of 2,260 m and then randomly sacrificed on days 1, 3, 7, 15 and 30 (n=10 each); and iii) simulated high altitude (SHA) group, in which 50 rats were maintained at a simulated altitude of 5,000 m, and then randomly sacrificed on days 1, 3, 7, 15 and 30 (n=10 each). The morphological changes of the thymus were observed, while the telomere length, the mRNA and protein expression levels of telomerase reverse transcriptase (TERT), and the peripheral blood lymphocyte count were measured. The results indicated that hypoxia induced morphological changes and apoptosis in thymocytes, as well as atrophy of the thymus tissue, and resulted in a significant increase in telomere length and TERT mRNA and protein expression levels. This effect appeared to be more pronounced in the SHA group compared with that in the MA group; however, no statistically significant changes were observed in the peripheral blood lymphocyte count. Based on these findings, the hypoxia-associated loss of thymic function appears to be only quantitative and not qualitative, and the thymus may be able to maintain its immune function even under hypoxic conditions.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhao Z, Yang Y, Zhao Y and Ge RL: Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions. Exp Ther Med 10: 1877-1882, 2015.
APA
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y., & Ge, R. (2015). Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions. Experimental and Therapeutic Medicine, 10, 1877-1882. https://doi.org/10.3892/etm.2015.2754
MLA
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y., Ge, R."Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions". Experimental and Therapeutic Medicine 10.5 (2015): 1877-1882.
Chicago
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y., Ge, R."Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1877-1882. https://doi.org/10.3892/etm.2015.2754
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhao Z, Yang Y, Zhao Y and Ge RL: Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions. Exp Ther Med 10: 1877-1882, 2015.
APA
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y., & Ge, R. (2015). Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions. Experimental and Therapeutic Medicine, 10, 1877-1882. https://doi.org/10.3892/etm.2015.2754
MLA
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y., Ge, R."Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions". Experimental and Therapeutic Medicine 10.5 (2015): 1877-1882.
Chicago
Wang, Y., Zhao, Z., Yang, Y., Zhao, Y., Ge, R."Thymocytes maintain immune activity through telomere elongation in rats under hypoxic conditions". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1877-1882. https://doi.org/10.3892/etm.2015.2754
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