Novel antiepileptic drug lacosamide exerts neuroprotective effects by decreasing glial activation in the hippocampus 
of a gerbil model of ischemic stroke

Ahn,Ji  Yun; Yan,Bing  Chun; Park,Joon  Ha; Ahn,Ji  Hyeon; Lee,Dae  Hwan; Kim,In  Hye; Cho,Jeong‑Hwi; Chen,Bai  Hui; Lee,Jae‑Chul; Cho,Young  Shin; Shin,Myoung  Chul; Cho,Jun  Hwi; Hong,Seongkweon; Won,Moo‑Ho; Kim,Sung  Koo

doi:10.3892/etm.2015.2794

Novel antiepileptic drug lacosamide exerts neuroprotective effects by decreasing glial activation in the hippocampus of a gerbil model of ischemic stroke

Authors:
- Ji Yun Ahn
- Bing Chun Yan
- Joon Ha Park
- Ji Hyeon Ahn
- Dae Hwan Lee
- In Hye Kim
- Jeong‑Hwi Cho
- Bai Hui Chen
- Jae‑Chul Lee
- Young Shin Cho
- Myoung Chul Shin
- Jun Hwi Cho
- Seongkweon Hong
- Moo‑Ho Won
- Sung Koo Kim
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Affiliations: Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea, Institute of Integrative Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea, Laboratory of Neuroscience, Department of Physical Therapy, College of Rehabilitation Science, Daegu University, Gyeongsan, North Gyeongsang 712‑714, Republic of Korea, Department of Physiology, College of Medicine, Hallym University, Chuncheon, Gangwon 200‑702, Republic of Korea, Department of Surgery, School of Medicine, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea, Department of Pediatrics, Dongtan Sacred Heart Hospital, School of Medicine, Hallym University, Hwaseong, Gyeonggi 445‑907, Republic of Korea
Published online on: October 13, 2015 https://doi.org/10.3892/etm.2015.2794
Pages: 2007-2014
Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lacosamide, which is a novel antiepileptic drug, has been reported to exert various additional therapeutic effects. The present study investigated the neuroprotective effects of lacosamide against transient cerebral ischemia‑induced neuronal cell damage in the hippocampal cornu ammonis (CA)‑1 region of a gerbil model. Neuronal Nuclei immunohistochemistry demonstrated that pre‑ and post‑surgical treatment (5 min ischemia) with 25 mg/kg lacosamide protected CA1 pyramidal neurons in the lacosamide‑treated‑ischemia‑operated group from ischemic injury 5 days post‑ischemia, as compared with gerbils in the vehicle‑treated‑ischemia‑operated group. Furthermore, treatment with 25 mg/kg lacosamide markedly attenuated the activation of astrocytes and microglia in the ischemic CA1 region at 5 days post‑ischemia. The results of the present study suggested that pre‑ and post‑surgical treatment of the gerbils with lacosamide was able to protect against transient cerebral ischemic injury‑induced CA1 pyramidal neuronal cell death in the hippocampus. In addition, the neuroprotective effects of lacosamide may be associated with decreased activation of glial cells in the ischemic CA1 region.

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