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Article

Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases

  • Authors:
    • Hong‑Yan Tong
    • Li Ye
    • Xing‑Nong Ye
    • De‑Min Lu
    • Ying Li
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 2295-2298
    |
    Published online on: October 14, 2015
       https://doi.org/10.3892/etm.2015.2797
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Abstract

Thrombotic thrombocytopenic purpura (TTP) is acquired in the majority of cases. Traditional therapy consists of plasma exchange (PEX), as well as the administration of certain immunosuppressive agents including steroids. A standard dose of rituximab (RTX) at 375 mg/m2 weekly for 4 consecutive weeks was recently demonstrated to have significant activity in patients with acquired TTP. To date, clinicians have limited experience using low‑dose RTX. In the present study, 2 patients were treated with low‑dose RTX at 100 mg weekly for 4 consecutive weeks as a salvage therapy following failure to respond to PEX and other immunosuppressive agents. Prior to RTX therapy, the patients had severely deficient ADAMTS13 activity and detectable anti‑ADAMTS13 inhibitors. The patients achieved complete remission and presented long‑term stabilization during follow‑up. Repeated detection during follow‑up demonstrated that the patients had 100% ADAMTS13 activity and undetectable anti‑ADAMTS13 antibodies. Although further investigation in a prospective clinical trial is required, the use of low‑dose RTX seems to be as effective as a standard dose for patients with relapsing or refractory acquired TTP.
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Copy and paste a formatted citation
Spandidos Publications style
Tong HY, Ye L, Ye XN, Lu DM and Li Y: Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases. Exp Ther Med 10: 2295-2298, 2015.
APA
Tong, H., Ye, L., Ye, X., Lu, D., & Li, Y. (2015). Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases. Experimental and Therapeutic Medicine, 10, 2295-2298. https://doi.org/10.3892/etm.2015.2797
MLA
Tong, H., Ye, L., Ye, X., Lu, D., Li, Y."Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases". Experimental and Therapeutic Medicine 10.6 (2015): 2295-2298.
Chicago
Tong, H., Ye, L., Ye, X., Lu, D., Li, Y."Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2295-2298. https://doi.org/10.3892/etm.2015.2797
Copy and paste a formatted citation
x
Spandidos Publications style
Tong HY, Ye L, Ye XN, Lu DM and Li Y: Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases. Exp Ther Med 10: 2295-2298, 2015.
APA
Tong, H., Ye, L., Ye, X., Lu, D., & Li, Y. (2015). Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases. Experimental and Therapeutic Medicine, 10, 2295-2298. https://doi.org/10.3892/etm.2015.2797
MLA
Tong, H., Ye, L., Ye, X., Lu, D., Li, Y."Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases". Experimental and Therapeutic Medicine 10.6 (2015): 2295-2298.
Chicago
Tong, H., Ye, L., Ye, X., Lu, D., Li, Y."Long-term remission induced by low-dose rituximab for relapsed and refractory thrombotic thrombocytopenic purpura: A report of two cases". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2295-2298. https://doi.org/10.3892/etm.2015.2797
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