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Article

Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain

  • Authors:
    • Yuanting Zhao
    • Yue Qin
    • Tuanjiang Liu
    • Dingjun Hao
  • View Affiliations / Copyright

    Affiliations: Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710054, P.R. China
  • Pages: 2384-2388
    |
    Published online on: October 15, 2015
       https://doi.org/10.3892/etm.2015.2801
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Abstract

Neuropathic pain, which is characterized by hyperalgesia, allodynia and spontaneous pain, is one of the most painful symptoms that can be experienced in the clinic. It often occurs as a result of injury to the peripheral nerves, dorsal root ganglion (DRG), spinal cord or brain. The renin‑angiotensin system (RAS) plays an important role in nociception. As an essential component of the RAS, the angiotensin (Ang)‑(1‑7)/Mas axis may be involved in antinociception. The aim of the present study was to explore the expression pattern of Mas in DRG neurons following chronic nerve injury and examine the effects of Mas inhibition and activation on neuropathic pain in a chronic constriction injury (CCI) rat model. The results showed, that compared with the sham group, CCI caused a time‑dependent induction of Mas expression at both the mRNA and the protein levels in DRG neurons. Consistent with the results, isolated DRG neurons showed a time‑dependent increase in Ang‑(1‑7) binding on the cell membrane following the CCI surgery, but not the sham surgery. Compared with the sham control groups, CCI significantly decreased the paw withdrawal latency and threshold, and this was markedly improved and aggravated by intrathecal injection of the selective Mas agonist Ang‑(1‑7) and the selective Mas inhibitor D‑Pro7‑Ang‑(1‑7), respectively. In conclusion, this study has provided the first evidence, to the best of our knowledge, that the Mas expression in DRG neurons is time‑dependently induced by chronic nerve injury and that the intrathecal activation and inhibition of Mas can improve and aggravate CCI‑induced neuropathic pain, respectively. This study has provided novel insights into the pathophysiological process of neuropathic pain and suggests that the Ang‑(1‑7)/Mas axis could be an effective therapeutic target for neuropathic pain, warranting further study.
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1 

Jensen TS, Baron R, Haanpüü M, Kalso E, Loeser JD, Rice AS and Treede R: A new definition of neuropathic pain. Pain. 152:2204–2205. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Grace PM, Hurley D, Barratt DT, Tsykin A, Watkins LR, Rolan PE and Hutchinson MR: Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: A novel correlational study design and bioinformatics approach in a graded chronic constriction injury model. J Neurochem. 122:976–994. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Lin HC, Huang YH, Chao TH, Lin WY, Sun WZ and Yen CT: Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain. Mol Pain. 10:632014. View Article : Google Scholar : PubMed/NCBI

4 

Obata K, Yamanaka H, Fukuoka T, Yi D, Tokunaga A, Hashimoto N, Yoshikawa H and Noguchi K: Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats. Pain. 101:65–77. 2003. View Article : Google Scholar : PubMed/NCBI

5 

de Gasparo M, Catt KJ, Inagami T, Wright JW and Unger T: International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 52:415–472. 2000.PubMed/NCBI

6 

Pelegrini-da-Silva A, Martins AR and Prado WA: A new role for the renin-angiotensin system in the rat periaqueductal gray matter: Angiotensin receptor-mediated modulation of nociception. Neuroscience. 132:453–463. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Sakagawa T, Okuyama S, Kawashima N, Hozumi S, Nakagawasai O, Tadano T, Kisara K, Ichiki T and Inagami T: Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor. Life Sci. 67:2577–2585. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Pavel J, Tang H, Brimijoin S, Moughamian A, Nishioku T, Benicky J and Saavedra JM: Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat. Brain Res. 1246:111–122. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Ferreira AJ, Murça TM, Fraga-Silva RA, Castro CH, Raizada MK and Santos RA: New cardiovascular and pulmonary therapeutic strategies based on the Angiotensin-converting enzyme 2/angiotensin-(1–7)/mas receptor axis. Int J Hypertens. 2012:1478252012. View Article : Google Scholar : PubMed/NCBI

10 

Raizada MK and Ferreira AJ: ACE2: A new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50:112–119. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, et al: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 277:14838–14843. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Der Sarkissian S, Huentelman MJ, Stewart J, Katovich MJ and Raizada MK: ACE2: A novel therapeutic target for cardiovascular diseases. Prog Biophys Mol Biol. 91:163–198. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Rice GI, Thomas DA, Grant PJ, Turner AJ and Hooper NM: Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 383:45–51. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Stanziola L, Greene LJ and Santos RA: Effect of chronic angiotensin converting enzyme inhibition on angiotensin I and bradykinin metabolism in rats. Am J Hypertens. 12:1021–1029. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Ferreira AJ and Santos RA: Cardiovascular actions of angiotensin-(1–7). Braz J Med Biol Res. 38:499–507. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Gomes ER, Santos RA and Guatimosim S: Angiotensin-(1–7)-mediated signaling in cardiomyocytes. Int J Hypertens. 2012:4931292012. View Article : Google Scholar : PubMed/NCBI

17 

Santos RA, Campagnole-Santos MJ and Andrade SP: Angiotensin-(1–7): An update. Regul Pept. 91:45–62. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Cao L, Xun J, Jiang X and Tan R: Propofol up-regulates Mas receptor expression in dorsal root ganglion neurons. Pharmazie. 68:677–680. 2013.PubMed/NCBI

19 

Costa AC, Becker LK, Moraes ER, Romero TR, Guzzo L, Santos RA and Duarte ID: Angiotensin-(1–7) induces peripheral antinociception through mas receptor activation in an opioid-independent pathway. Pharmacology. 89:137–144. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Bennett G and Xie Y: A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:87–107. 1988. View Article : Google Scholar : PubMed/NCBI

21 

Zanella JM, Burright EN, Hildebrand K, Hobot C, Cox M, Christoferson L and Mckay WF: Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model. Spine (Phila Pa 1976). 33:227–234. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Melli G and Höke A: Dorsal root ganglia sensory neuronal cultures: A tool for drug discovery for peripheral neuropathies. Expert Opin Drug Discov. 4:1035–1045. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Gironacci MM, Adamo HP, Corradi G, Santos RA, Ortiz P and Carretero OA: Angiotensin (1–7) induces MAS receptor internalization. Hypertension. 58:176–181. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Mizoguchi H, Watanabe C, Yonezawa A and Sakurada S: New therapy for neuropathic pain. Int Rev Neurobiol. 85:249–260. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Silva DM, Vianna HR, Cortes SF, Campagnole-Santos MJ, Santos RA and Lemos VS: Evidence for a new angiotensin-(1–7) receptor subtype in the aorta of Sprague-Dawley rats. Peptides. 28:702–707. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Medeiros MA, França MS, Boileau G, Juliano L and Carvalho KM: Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases. Braz J Med Biol Res. 30:1157–1162. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Qin Y, Liu T and Hao D: Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain. Exp Ther Med 10: 2384-2388, 2015.
APA
Zhao, Y., Qin, Y., Liu, T., & Hao, D. (2015). Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain. Experimental and Therapeutic Medicine, 10, 2384-2388. https://doi.org/10.3892/etm.2015.2801
MLA
Zhao, Y., Qin, Y., Liu, T., Hao, D."Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain". Experimental and Therapeutic Medicine 10.6 (2015): 2384-2388.
Chicago
Zhao, Y., Qin, Y., Liu, T., Hao, D."Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2384-2388. https://doi.org/10.3892/etm.2015.2801
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Qin Y, Liu T and Hao D: Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain. Exp Ther Med 10: 2384-2388, 2015.
APA
Zhao, Y., Qin, Y., Liu, T., & Hao, D. (2015). Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain. Experimental and Therapeutic Medicine, 10, 2384-2388. https://doi.org/10.3892/etm.2015.2801
MLA
Zhao, Y., Qin, Y., Liu, T., Hao, D."Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain". Experimental and Therapeutic Medicine 10.6 (2015): 2384-2388.
Chicago
Zhao, Y., Qin, Y., Liu, T., Hao, D."Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2384-2388. https://doi.org/10.3892/etm.2015.2801
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