Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2015 Volume 10 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2015 Volume 10 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma

  • Authors:
    • Yong Gao
    • Puxian Li
    • Zhenrui Liu
    • Xingtao Diao
    • Chunyun Song
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, People's Hospital of Laiwu, Laiwu, Shandong 271100, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2138-2144
    |
    Published online on: October 16, 2015
       https://doi.org/10.3892/etm.2015.2810
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the roles of the vascular endothelial cell growth factor (VEGF) and micro (mi)RNA‑210 in the metastasis of primary medulloblastoma (MB) tumors. A total of 86 adult patients diagnosed with cerebellar MB were enrolled in the present study, of which 11 patients had metastatic MB in the subarachnoid space. The following samples were collected: MB primary tumor tissue, MB secondary tumor tissue, tumor adjacent tissues and cerebrospinal fluid (CSF). Immunohistochemical analyses of the tissue samples were conducted in order to detect patterns of VEGF expression. In addition, the expression levels of VEGF mRNA and miRNA‑210 were analyzed using reverse transcription‑quantititative polymerase chain reaction, and western blot analyses were used to investigate VEGF protein expression levels. The positive expression rate of VEGF was significantly higher in MB tumor tissue, as compared with adjacent tissues (P<0.01). In addition, VEGF mRNA and protein expression levels in MB primary and secondary tumor tissues, and in the CSF of patients with metastatic MB, were significantly upregulated, as compared with tumor adjacent tissues and the CSF of patients with non‑metastatic MB, respectively (P<0.01). miRNA‑210 expression levels were significantly upregulated in MB tumor tissues, the CSF of patients with metastatic MB and in tumor tissues of metastatic MB (P<0.01). In the present study, the expression levels of VEGF and miRNA‑210 were upregulated in patients with MB and metastatic MB; thus suggesting that miRNA‑210 may promote the metastasis of MB primary tumors by regulating the expression of VEGF.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sardiñas N, Marcos R, Pestaña EM, Vargas J, Chi-Ramírez D, Rojas E, Esteban EM and Zarrabeitía L: Tumors of the posterior fossa in children. Rev Neurol. 28:1153–1158. 1999.(In Spanish). PubMed/NCBI

2 

Packer RJ, Cogen P, Vezina G and Rorke LB: Medulloblastoma: Clinical and biologic aspects. Neuro Oncol. 1:232–250. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Yan XY: Angiogenesis: A promising strategy for tumor therapy. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 26:180–193. 2010.(In Chinese).

4 

Lohela M, Bry M, Tammela T and Alitalo K: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol. 21:154–165. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Roberts E, Cossigny DA and Quan GM: The role of vascular endothelial growth factor in metastatic prostate cancer to the skeleton. Prostate Cancer. 2013:4183402013. View Article : Google Scholar : PubMed/NCBI

6 

Mao X, Wang T, Liu Y, Irwin MG, Ou JS, Liao XL, Gao X, Xu Y, Ng KF, Vanhoutte PM and Xia Z: N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats. PLoS One. 8:e689492013. View Article : Google Scholar : PubMed/NCBI

7 

Vimala N, Mittal S, Kumar S, Dadhwal V and Sharma Y: A randomized comparison of sublingual and vaginal misoprostol for cervical priming before suction termination of first-trimester pregnancy. Contraception. 70:117–120. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Mende A, Takano H, Kodama Y, Nakamura T, Umetani K, Fujioka D, Saito Y, Kobayashi T, Kawabata K, Obata JE, et al: Relation between transcardiac gradient of VEGF and coronary flow response in humans. Int J Cardiol. 119:156–162. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Stumpf C, Jukic J, Yilmaz A, Raaz D, Schmieder RE, Daniel WG and Garlichs CD: Elevated VEGF-plasma levels in young patients with mild essential hypertension. Eur J Clin Invest. 39:31–36. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Xiong N, Zhang Z, Huang J, Chen C, Zhang Z, Jia M, Xiong J, Liu X, Wang F, Cao X, et al: VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Ther. 18:394–402. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Kim NH, Jung HH, Cha DR and Choi DS: Expression of vascular endothelial growth factor in response to high glucose in rat mesangial cells. J Endocrinol. 165:617–624. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Li H, Wang Y, Liu F, Lou YL, Deng J and Cui SP: Dynamic changes of the expression of hypoxia inducible factor-1α and the target genes miR-210, vascular endothelial growth factor in the kidney after ischemic-reperfusion injury. Zhong Hua Shi Yan Wai Ke Za Zhi. 28:2074–2076. 2011.(In Chinese).

13 

Cha HS, Bae EK, Koh JH, Chai JY, Jeon CH, Ahn KS, Kim J and Koh EM: Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes. J Rheumatol. 34:16–19. 2007.PubMed/NCBI

14 

Agrawal R, Pandey P, Jha P, Dwivedi V, Sarkar C and Kulshreshtha R: Hypoxic signature of microRNAs in glioblastoma: Insights from small RNA deep sequencing. BMC Genomics. 15:6862014. View Article : Google Scholar : PubMed/NCBI

15 

Liu SQ, Yu HC, Gong YZ and Lai NS: Quantitiative measurement of HLA-B27 mRNA in patients with ankylosing spondylitis - correlation with clinical activity. J Rheumatol. 33:1128–1132. 2006.PubMed/NCBI

16 

Brahimi-Horn MC, Chiche J and Pouysségur J: Hypoxia and cancer. J Mol Med (Berl). 85:1301–1307. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Cohen AL and Colman H: Glioma biology and molecular markers. Cancer Treat Res. 163:15–30. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Barai S, Bandopadhayaya GP, Julka PK, Dhanapathi H, Haloi AK and Seith A: Cerebellar medulloblastoma presenting with skeletal metastasis. J Postgrad Med. 50:110–112. 2004.PubMed/NCBI

19 

Slongo ML, Molena B, Brunati AM, Frasson M, Gardiman M, Carli M, Perilongo G, Rosolen A and Onisto M: Functional VEGF and VEGF receptors are expressed in human medulloblastomas. Neuro Oncol. 9:384–392. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Quero L, Dubois L, Lieuwes NG, Hennequin C and Lambin P: miR-210 as a marker of chronic hypoxia, but not a therapeutic target in prostate cancer. Radiother Oncol. 101:203–208. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zeng L, He X, Wang Y, Tang Y, Zheng C, Cai H, Liu J, Wang Y, Fu Y and Yang GY: MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain. Gene Ther. 21:37–43. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Lou Y, Gao F, Xie A, Guo F, Deng Z and Wang Y: MicroRNA-210 modified human umbilical vein endothelial cells induce capillary formation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 26:587–591. 2012.(In Chinese). PubMed/NCBI

23 

Shoji T, Nakasa T, Yamasaki K, Kodama A, Miyaki S, Niimoto T, Okuhara A, Kamei N, Adachi N and Ochi M: The effect of intra-articular injection of microRNA-210 on ligament healing in a rat model. Am J Sports Med. 40:2470–2478. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Szabó DR, Luconi M, Szabó PM, Tóth M, Szücs N, Horányi J, Nagy Z, Mannelli M, Patócs A, Rácz K and Igaz P: Analysis of circulating microRNAs in adrenocortical tumors. Lab Invest. 94:331–339. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Alaiti MA, Ishikawa M, Masuda H, Simon DI, Jain MK, Asahara T and Costa MA: Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD34+ cells enhances cell-mediated angiogenesis. J Cell Mol Med. 16:2413–2421. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Li P, Liu Z, Diao X and Song C: Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma. Exp Ther Med 10: 2138-2144, 2015.
APA
Gao, Y., Li, P., Liu, Z., Diao, X., & Song, C. (2015). Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma. Experimental and Therapeutic Medicine, 10, 2138-2144. https://doi.org/10.3892/etm.2015.2810
MLA
Gao, Y., Li, P., Liu, Z., Diao, X., Song, C."Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma". Experimental and Therapeutic Medicine 10.6 (2015): 2138-2144.
Chicago
Gao, Y., Li, P., Liu, Z., Diao, X., Song, C."Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2138-2144. https://doi.org/10.3892/etm.2015.2810
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Li P, Liu Z, Diao X and Song C: Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma. Exp Ther Med 10: 2138-2144, 2015.
APA
Gao, Y., Li, P., Liu, Z., Diao, X., & Song, C. (2015). Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma. Experimental and Therapeutic Medicine, 10, 2138-2144. https://doi.org/10.3892/etm.2015.2810
MLA
Gao, Y., Li, P., Liu, Z., Diao, X., Song, C."Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma". Experimental and Therapeutic Medicine 10.6 (2015): 2138-2144.
Chicago
Gao, Y., Li, P., Liu, Z., Diao, X., Song, C."Expression levels of vascular endothelial cell growth factor and microRNA‑210 are increased in medulloblastoma and metastatic medulloblastoma". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2138-2144. https://doi.org/10.3892/etm.2015.2810
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team