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Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer

  • Authors:
    • Zhi‑Hua Zhao
    • Feng‑Qi Li
    • Jian‑Kui Han
    • Xian‑Jun Li
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Qilu Hospital, Shangdong University, Jinan, Shangdong 250012, P.R. China, Department of Nuclear Medicine, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2079-2082
    |
    Published online on: October 19, 2015
       https://doi.org/10.3892/etm.2015.2812
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Abstract

Thyroid cancer is a common malignant tumor of the endocrine glands. Although surgery is the optimal treatment utilized, the disease is characterized by recurrence and metastasis. The aim of the present study was to determine the effect of iodine‑131 (131I) ‘clear residual thyroid tissue’ following surgery on the treatment of differentiated thyroid cancer (DTC) and its effect on the function of the parathyroid gland. A total of 160 patients diagnosed with DTC, who were consecutively admitted to our Hospital between June 2012 and June 2014 and underwent total thyroidectomy or subtotal resection, were included in the present study. After three months, the patients were administered 131I ‘clear residual thyroid tissue’ treatment and underwent a whole body scan after 1 week to determine whether ‘clear residual thyroid tissue’ treatment was successful or not. The treatment was repeated within 3 months if not successful. Of the 160 patients, 24 patients had cancer metastasis (15.0%). The average dose of 131I used for the first time was 6.4+1.2 GBq and the treatment was successful in 66 cases (41.3%). The average treatment time was 2.8±0.6 therapy sessions. The results showed that, prior to and following the first treatment and at the end of the follow up, levels of the parathyroid hormone, serum calcium and phosphorus were compared, and no statistically significant difference (P>0.05) was observed. There were 5 patients with persistent hypothyroidism and 8 patients with transient hypothyroidism. The levels of thyroglobulin were significantly decreased, and the difference was statistically significant (P<0.05). A total of 48 patients (30%) with hypothyroidism were identified. In conclusion, the results have shown that DTC resection and 131I ‘clear residual thyroid tissue’ treatment did not significantly impair the parathyroid function, thereby improving the treatment effect.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao ZH, Li FQ, Han JK and Li XJ: Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer. Exp Ther Med 10: 2079-2082, 2015.
APA
Zhao, Z., Li, F., Han, J., & Li, X. (2015). Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer. Experimental and Therapeutic Medicine, 10, 2079-2082. https://doi.org/10.3892/etm.2015.2812
MLA
Zhao, Z., Li, F., Han, J., Li, X."Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer". Experimental and Therapeutic Medicine 10.6 (2015): 2079-2082.
Chicago
Zhao, Z., Li, F., Han, J., Li, X."Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2079-2082. https://doi.org/10.3892/etm.2015.2812
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao ZH, Li FQ, Han JK and Li XJ: Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer. Exp Ther Med 10: 2079-2082, 2015.
APA
Zhao, Z., Li, F., Han, J., & Li, X. (2015). Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer. Experimental and Therapeutic Medicine, 10, 2079-2082. https://doi.org/10.3892/etm.2015.2812
MLA
Zhao, Z., Li, F., Han, J., Li, X."Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer". Experimental and Therapeutic Medicine 10.6 (2015): 2079-2082.
Chicago
Zhao, Z., Li, F., Han, J., Li, X."Effect of 131I ‘clear residual thyroid tissue’ after surgery on the function of parathyroid gland in differentiated thyroid cancer". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2079-2082. https://doi.org/10.3892/etm.2015.2812
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