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Article

Naringenin attenuates pressure overload-induced cardiac hypertrophy

  • Authors:
    • Ning Zhang
    • Zheng Yang
    • Yuan Yuan
    • Fangfang Li
    • Yuan Liu
    • Zhenguo Ma
    • Haihan Liao
    • Zhouyan Bian
    • Yao Zhang
    • Heng Zhou
    • Wei Deng
    • Mengqiao Zhou
    • Qizhu Tang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 2206-2212
    |
    Published online on: October 19, 2015
       https://doi.org/10.3892/etm.2015.2816
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Abstract

Cardiac hypertrophy is characterized by abnormal enlargement of cardiomyocytes and disproportionate accumulation of extracellular interstitial fibrosis, which are major predictors of the development of coronary artery disease and heart failure. Naringenin is a bitter principle component of grapefruit that has numerous pharmacological effects, including anti‑inflammatory, hypolipidemic, antithrombotic and antiatherogenic properties. In order to investigate whether naringenin is able to exert a protective effect against cardiac hypertrophy induced by pressure overload, aortic banding (AB) was performed to induce cardiac hypertrophy in mice, and naringenin was administered for 7 weeks. A total of 60 mice were allocated into four groups: Sham + vehicle, AB + vehicle, sham + naringenin and AB + naringenin. Naringenin treatment attenuated cardiac dysfunction, as indicated by the results of echocardiography and catheter‑based measurements at 8 weeks post‑surgery. The extent of cardiac hypertrophy was assessed by the heart weight/body weight, heart weight/tibial length and lung weight/body weight ratios, in addition to the cardiomyocyte cross‑sectional area and the mRNA expression levels of hypertrophic maker, all of which were mitigated by naringenin administration. Naringenin also inhibited the expression of transforming growth factor‑β1, connective tissue growth factor, collagen Iα and collagen IIIα, and attenuated interstitial fibrosis. In addition, naringenin downregulated the activation of the extracellular signal‑regulated kinase (ERK), c‑Jun N‑terminal kinase (JNK) and phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathways. In conclusion, naringenin attenuated cardiac hypertrophy and interstitial fibrosis, in addition to improving left ventricular function in pressure‑overloaded mice. The cardioprotective effect exerted by naringenin may be associated with the inhibition of PI3K/Akt, ERK and JNK signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang N, Yang Z, Yuan Y, Li F, Liu Y, Ma Z, Liao H, Bian Z, Zhang Y, Zhou H, Zhou H, et al: Naringenin attenuates pressure overload-induced cardiac hypertrophy. Exp Ther Med 10: 2206-2212, 2015.
APA
Zhang, N., Yang, Z., Yuan, Y., Li, F., Liu, Y., Ma, Z. ... Tang, Q. (2015). Naringenin attenuates pressure overload-induced cardiac hypertrophy. Experimental and Therapeutic Medicine, 10, 2206-2212. https://doi.org/10.3892/etm.2015.2816
MLA
Zhang, N., Yang, Z., Yuan, Y., Li, F., Liu, Y., Ma, Z., Liao, H., Bian, Z., Zhang, Y., Zhou, H., Deng, W., Zhou, M., Tang, Q."Naringenin attenuates pressure overload-induced cardiac hypertrophy". Experimental and Therapeutic Medicine 10.6 (2015): 2206-2212.
Chicago
Zhang, N., Yang, Z., Yuan, Y., Li, F., Liu, Y., Ma, Z., Liao, H., Bian, Z., Zhang, Y., Zhou, H., Deng, W., Zhou, M., Tang, Q."Naringenin attenuates pressure overload-induced cardiac hypertrophy". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2206-2212. https://doi.org/10.3892/etm.2015.2816
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang N, Yang Z, Yuan Y, Li F, Liu Y, Ma Z, Liao H, Bian Z, Zhang Y, Zhou H, Zhou H, et al: Naringenin attenuates pressure overload-induced cardiac hypertrophy. Exp Ther Med 10: 2206-2212, 2015.
APA
Zhang, N., Yang, Z., Yuan, Y., Li, F., Liu, Y., Ma, Z. ... Tang, Q. (2015). Naringenin attenuates pressure overload-induced cardiac hypertrophy. Experimental and Therapeutic Medicine, 10, 2206-2212. https://doi.org/10.3892/etm.2015.2816
MLA
Zhang, N., Yang, Z., Yuan, Y., Li, F., Liu, Y., Ma, Z., Liao, H., Bian, Z., Zhang, Y., Zhou, H., Deng, W., Zhou, M., Tang, Q."Naringenin attenuates pressure overload-induced cardiac hypertrophy". Experimental and Therapeutic Medicine 10.6 (2015): 2206-2212.
Chicago
Zhang, N., Yang, Z., Yuan, Y., Li, F., Liu, Y., Ma, Z., Liao, H., Bian, Z., Zhang, Y., Zhou, H., Deng, W., Zhou, M., Tang, Q."Naringenin attenuates pressure overload-induced cardiac hypertrophy". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2206-2212. https://doi.org/10.3892/etm.2015.2816
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