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Article

microRNA and gene networks in human laryngeal cancer

  • Authors:
    • Fengyu Zhang
    • Zhiwen Xu
    • Kunhao Wang
    • Linlin Sun
    • Genghe Liu
    • Baixu Han
  • View Affiliations / Copyright

    Affiliations: College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 2245-2252
    |
    Published online on: October 23, 2015
       https://doi.org/10.3892/etm.2015.2825
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Abstract

Genes and microRNAs (miRNAs) are considered to be key biological factors in human carcinogenesis. To date, considerable data have been obtained regarding genes and miRNAs in cancer; however, the regulatory mechanisms associated with the genes and miRNAs in cancer have yet to be fully elucidated. The aim of the present study was to use the key genes and miRNAs associated with laryngeal cancer (LC) to construct three regulatory networks (differentially expressed, LC‑related and global). A network topology of the development of LC, involving 10 differentially expressed miRNAs and 55 differentially expressed genes, was obtained. These genes exhibited multiple identities, including target genes of miRNA, transcription factors (TFs) and host genes. The key regulatory interactions were determined by comparing the similarities and differences among the three networks. The nodes and pathways in LC, as well as the association between each pair of factors within the networks, such as TFs and miRNA, miRNA and target genes and miRNA and its host gene, were discussed. The mechanisms of LC involved certain key pathways featuring self‑adaptation regulation and nodes without direct predecessors or successors. The findings of the present study have further elucidated the pathogenesis of LC and are likely to be beneficial for future research into LC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Xu Z, Wang K, Sun L, Liu G and Han B: microRNA and gene networks in human laryngeal cancer. Exp Ther Med 10: 2245-2252, 2015.
APA
Zhang, F., Xu, Z., Wang, K., Sun, L., Liu, G., & Han, B. (2015). microRNA and gene networks in human laryngeal cancer. Experimental and Therapeutic Medicine, 10, 2245-2252. https://doi.org/10.3892/etm.2015.2825
MLA
Zhang, F., Xu, Z., Wang, K., Sun, L., Liu, G., Han, B."microRNA and gene networks in human laryngeal cancer". Experimental and Therapeutic Medicine 10.6 (2015): 2245-2252.
Chicago
Zhang, F., Xu, Z., Wang, K., Sun, L., Liu, G., Han, B."microRNA and gene networks in human laryngeal cancer". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2245-2252. https://doi.org/10.3892/etm.2015.2825
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Xu Z, Wang K, Sun L, Liu G and Han B: microRNA and gene networks in human laryngeal cancer. Exp Ther Med 10: 2245-2252, 2015.
APA
Zhang, F., Xu, Z., Wang, K., Sun, L., Liu, G., & Han, B. (2015). microRNA and gene networks in human laryngeal cancer. Experimental and Therapeutic Medicine, 10, 2245-2252. https://doi.org/10.3892/etm.2015.2825
MLA
Zhang, F., Xu, Z., Wang, K., Sun, L., Liu, G., Han, B."microRNA and gene networks in human laryngeal cancer". Experimental and Therapeutic Medicine 10.6 (2015): 2245-2252.
Chicago
Zhang, F., Xu, Z., Wang, K., Sun, L., Liu, G., Han, B."microRNA and gene networks in human laryngeal cancer". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2245-2252. https://doi.org/10.3892/etm.2015.2825
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