Pterygium concomitant with other ocular surface lesions: Clinical implications and pathogenetic links

Detorakis,Efstathios  T.; Kymionis,George; Tsatsos,Michael; Spandidos,Demetrios  A.

doi:10.3892/etm.2015.2865

January-2016 Volume 11 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January-2016 Volume 11 Issue 1

Full Size Image

Article Open Access

Pterygium concomitant with other ocular surface lesions: Clinical implications and pathogenetic links

Authors:
- Efstathios T. Detorakis
- George Kymionis
- Michael Tsatsos
- Demetrios A. Spandidos
View Affiliations / Copyright

Affiliations: Department of Ophthalmology, University Hospital of Heraklion, Heraklion 71110, Greece, Institute of Vision and Optics, University of Crete, Heraklion 71003, Greece, Moorfields Eye Hospital, London EC1V 2PD, UK, Laboratory of Clinical Virology, University of Crete, Medical School, Heraklion 71409, Greece

Copyright: © Detorakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 69-72
|
Published online on: November 13, 2015

https://doi.org/10.3892/etm.2015.2865
Expand metrics +

Abstract

In the present study, we aimed to evaluate the co-existence of ophthalmic pterygium with other ocular surface lesions in a cohort of patients from the Cretan population. This is a retrospective evaluation of all pterygia in patients examined and treated at the Department of Ophthalmology of the University Hospital of Heraklion, Greece during an 8‑year period (from June 2006 to June 2014). A total of 158 cases was examined. Ocular surface images and medical history were evaluated in order to detect concomitant ocular surface pathological conditions. Concomitant lesions included conjunctival nevi (5 cases, 3.16%), iris nevi (4 cases, 2.53%), conjunctival papillomas (8 cases, 5.06%), conjunctival intraepithelial neoplasia (CIN; 4 cases, 2.53%) and 6 cases of hypertophy of the plica semilunaris (3.79%). Of note, pterygium was overlying the iris which was occupied by the iris nevus in 2 out of the 4 cases of iris nevus. Overall, our data indicate that ophthalmic pterygium may often co‑exist with other clinically significant ocular surface lesions. The association of ophthalmic pterygium with conjunctival papillomas or CIN stresses the potential involvement of human papilloma virus in the pathogenesis of ophthalmic pterygium, whereas the topographical association of pterygium with iris nevus may offer support to the transcameral light pathway pathogenetic mechanism.

View Figures

View References

1	Detorakis ET and Spandidos DA: Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review). Int J Mol Med. 23:439–447. 2009. View Article : Google Scholar : PubMed/NCBI
2	Coroneo MT: Pterygium as an early indicator of ultraviolet insolation: a hypothesis. Br J Ophthalmol. 77:734–739. 1993. View Article : Google Scholar : PubMed/NCBI
3	Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D and Di Girolamo N: Ophthalmic pterygium: a stem cell disorder with premalignant features. Am J Pathol. 178:817–827. 2011. View Article : Google Scholar : PubMed/NCBI
4	Detorakis ET, Zaravinos A and Spandidos DA: Growth factor expression in ophthalmic pterygia and normal conjunctiva. Int J Mol Med. 25:513–516. 2010. View Article : Google Scholar : PubMed/NCBI
5	Detorakis ET, Sourvinos G, Tsamparlakis J and Spandidos DA: Evaluation of loss of heterozygosity and microsatellite instability in human pterygium: clinical correlations. Br J Ophthalmol. 82:1324–1328. 1998. View Article : Google Scholar : PubMed/NCBI
6	Detorakis ET, Drakonaki EE and Spandidos DA: Molecular genetic alterations and viral presence in ophthalmic pterygium. Int J Mol Med. 6:35–41. 2000.PubMed/NCBI
7	Detorakis ET, Sourvinos G and Spandidos DA: Detection of herpes simplex virus and human papilloma virus in ophthalmic pterygium. Cornea. 20:164–167. 2001. View Article : Google Scholar : PubMed/NCBI
8	Gallagher MJ, Giannoudis A, Herrington CS and Hiscott P: Human papillomavirus in pterygium. Br J Ophthalmol. 85:782–784. 2001. View Article : Google Scholar : PubMed/NCBI
9	Piras F, Moore PS, Ugalde J, Perra MT, Scarpa A and Sirigu P: Detection of human papillomavirus DNA in pterygia from different geographical regions. Br J Ophthalmol. 87:864–866. 2003. View Article : Google Scholar : PubMed/NCBI
10	Saw SM and Tan D: Pterygium: prevalence, demography and risk factors. Ophthalmic Epidemiol. 6:219–228. 1999. View Article : Google Scholar : PubMed/NCBI
11	Degrassi M, Piantanida A and Nucci P: Unexpected histological findings in pterygium. Optom Vis Sci. 70:1058–1060. 1993. View Article : Google Scholar : PubMed/NCBI
12	Artornsombudh P, Sanpavat A, Tinnungwattana U, Tongkhomsai V, Sansopha L and Tulvatana W: Prevalence and clinicopathologic findings of conjunctival epithelial neoplasia in pterygia. Ophthalmology. 120:1337–1340. 2013. View Article : Google Scholar : PubMed/NCBI
13	Perra MT, Colombari R, Maxia C, Zucca I, Piras F, Corbu A, Bravo S, Scarpa A and Sirigu P: Finding of conjunctival melanocytic pigmented lesions within pterygium. Histopathology. 48:387–393. 2006. View Article : Google Scholar : PubMed/NCBI
14	Detorakis ET, Halkia A, Tsakalaki V and Spandidos DA: Association between pterygium and plica semilunaris morphology. Clin Experiment Ophthalmol. 41:891–892. 2013. View Article : Google Scholar : PubMed/NCBI
15	Harbour JW, Brantley MA Jr, Hollingsworth H and Gordon M: Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. Br J Ophthalmol. 88:36–38. 2004. View Article : Google Scholar : PubMed/NCBI
16	Coroneo M: Ultraviolet radiation and the anterior eye. Eye Contact Lens. 37:214–224. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pterygium concomitant with other ocular surface lesions: Clinical implications and pathogenetic links

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles