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Article

Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene

  • Authors:
    • Shi‑Min Xu
    • Ting Liang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Administration, People's Hospital of Langfang, Langfang, Hebei 065000, P.R. China
  • Pages: 283-288
    |
    Published online on: November 24, 2015
       https://doi.org/10.3892/etm.2015.2888
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Abstract

The aim of the present study was to investigate the optimal mobilization plan in autologous peripheral blood stem cell transplantation for the treatment of diabetic foot and to observe its clinical curative effect. A total of 127 patients with diabetic foot were treated with different doses of granulocyte colony stimulating factor (G‑CSF) to mobilize their hematopoietic stem cells. Subsequently, the extracted stem cell suspension was injected into the ischemic lower extremities along the blood vessels in the areas presenting with pathological changes. Following the treatment, the intermittent claudication distance, skin temperature, ankle brachial index and pain scores of the patients were evaluated. In addition, the associations among the mobilization time, doses and peripheral blood CD34+ level were analyzed. The collection efficiency of the stem cells was associated with the dose of G‑CSF and the mobilization time. Following the injection of the autologous peripheral blood stem cell suspension, the ischemic area of the patients was improved significantly. In conclusion, autologous peripheral blood stem cell transplantation can promote the establishment of collateral circulation in patients with diabetic foot, and the optimal time for gathering stem cells is closely correlated with the peripheral blood CD34+ level.
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Copy and paste a formatted citation
Spandidos Publications style
Xu SM and Liang T: Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene. Exp Ther Med 11: 283-288, 2016.
APA
Xu, S., & Liang, T. (2016). Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene. Experimental and Therapeutic Medicine, 11, 283-288. https://doi.org/10.3892/etm.2015.2888
MLA
Xu, S., Liang, T."Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene". Experimental and Therapeutic Medicine 11.1 (2016): 283-288.
Chicago
Xu, S., Liang, T."Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene". Experimental and Therapeutic Medicine 11, no. 1 (2016): 283-288. https://doi.org/10.3892/etm.2015.2888
Copy and paste a formatted citation
x
Spandidos Publications style
Xu SM and Liang T: Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene. Exp Ther Med 11: 283-288, 2016.
APA
Xu, S., & Liang, T. (2016). Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene. Experimental and Therapeutic Medicine, 11, 283-288. https://doi.org/10.3892/etm.2015.2888
MLA
Xu, S., Liang, T."Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene". Experimental and Therapeutic Medicine 11.1 (2016): 283-288.
Chicago
Xu, S., Liang, T."Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene". Experimental and Therapeutic Medicine 11, no. 1 (2016): 283-288. https://doi.org/10.3892/etm.2015.2888
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