Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide‑induced acute lung injury in mice

  • Authors:
    • Zuqing Su
    • Jinbin Liao
    • Yuhong Liu
    • Yongzhuo Liang
    • Haiming Chen
    • Xiaoying Chen
    • Xiaoping Lai
    • Xuexuan Feng
    • Dianwei Wu
    • Yifeng Zheng
    • Xiaojun Zhang
    • Yucui Li
  • View Affiliations

  • Published online on: December 8, 2015     https://doi.org/10.3892/etm.2015.2918
  • Pages: 674-682
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Abstract

Patchouli alcohol (PA) is a tricyclic sesquiterpene isolated from Pogostemon cablin, which exerts anti‑inflammatory, anti‑influenza and cognitive‑enhancing bioactivities. The present study aimed to investigate the protective effects of PA on acute lung injury (ALI) induced by intratracheal instillation of lipopolysaccharide (LPS) in mice. Dexamethasone was used as a positive drug for protection against LPS‑induced ALI. The results of the present study demonstrated that pretreatment with PA significantly increased survival rate, attenuated histopathologic damage and lung edema, and decreased the protein content in the bronchoalveolar lavage fluid (BALF) of mice with ALI. Furthermore, PA significantly inhibited the expression levels of proinflammatory cytokines, including tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 in the BALF, downregulated the levels of myeloperoxidase and malondialdehyde, and upregulated the activity levels of superoxide dismutase and glutathione peroxidase in lung tissue. These results indicated that PA may exert potent protective effects against LPS‑induced ALI in mice, the mechanisms of which are possibly associated with the anti‑inflammatory and antioxidative activities of PA.
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February-2016
Volume 11 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Su Z, Liao J, Liu Y, Liang Y, Chen H, Chen X, Lai X, Feng X, Wu D, Zheng Y, Zheng Y, et al: Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide‑induced acute lung injury in mice. Exp Ther Med 11: 674-682, 2016.
APA
Su, Z., Liao, J., Liu, Y., Liang, Y., Chen, H., Chen, X. ... Li, Y. (2016). Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide‑induced acute lung injury in mice. Experimental and Therapeutic Medicine, 11, 674-682. https://doi.org/10.3892/etm.2015.2918
MLA
Su, Z., Liao, J., Liu, Y., Liang, Y., Chen, H., Chen, X., Lai, X., Feng, X., Wu, D., Zheng, Y., Zhang, X., Li, Y."Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide‑induced acute lung injury in mice". Experimental and Therapeutic Medicine 11.2 (2016): 674-682.
Chicago
Su, Z., Liao, J., Liu, Y., Liang, Y., Chen, H., Chen, X., Lai, X., Feng, X., Wu, D., Zheng, Y., Zhang, X., Li, Y."Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide‑induced acute lung injury in mice". Experimental and Therapeutic Medicine 11, no. 2 (2016): 674-682. https://doi.org/10.3892/etm.2015.2918