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Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer

  • Authors:
    • Yongtian Fan
    • Dechuan Li
    • Jun Qian
    • Yong Liu
    • Haiyang Feng
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 421-426
    |
    Published online on: December 11, 2015
       https://doi.org/10.3892/etm.2015.2933
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Abstract

The aim of the present study was to detect the expression levels of FERM domain‑containing 4A (FRMD4A) in rectal cancer tissues and peripheral blood and to investigate the correlation between FRMD4A and cancer development. A total of 78 consecutive patients were enrolled in this study. Thirty healthy individuals were used as the control group. The expression of FRMD4A in rectal cancer and the corresponding normal adjacent tissues was detected by immunohistochemistry and western blotting. The expression of FRMD4A mRNA in peripheral blood was detected by reverse transcription‑quantitative polymerase chain reaction. The expression of FRMD4A in rectal cancer tissues was found to be negatively correlated with the degree of differentiation, depth of invasion and Dukes' stage. A negative correlation was identified between FRMD4A and epithelial cadherin expression. The expression of FRMD4A in the peripheral blood of patients with rectal cancer was significantly increased compared with that in the control group (P<0.05). Expression of FRMD4A in the peripheral blood in the patients with lymph node metastasis was significantly increased compared with that in the patients without lymph node metastasis (P<0.05). These results indicate that the expression of FRMD4A is significantly increased in rectal cancer tissues and the peripheral blood of patients with rectal cancer, and the expression levels of FRMD4A are closely associated with differentiation, invasion of rectal cancer and Dukes' stage. In conclusion, the findings of the present study suggest that FRMD4A may be used as a target for the diagnosis and treatment of rectal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Fan Y, Li D, Qian J, Liu Y and Feng H: Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer. Exp Ther Med 11: 421-426, 2016.
APA
Fan, Y., Li, D., Qian, J., Liu, Y., & Feng, H. (2016). Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer. Experimental and Therapeutic Medicine, 11, 421-426. https://doi.org/10.3892/etm.2015.2933
MLA
Fan, Y., Li, D., Qian, J., Liu, Y., Feng, H."Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer". Experimental and Therapeutic Medicine 11.2 (2016): 421-426.
Chicago
Fan, Y., Li, D., Qian, J., Liu, Y., Feng, H."Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer". Experimental and Therapeutic Medicine 11, no. 2 (2016): 421-426. https://doi.org/10.3892/etm.2015.2933
Copy and paste a formatted citation
x
Spandidos Publications style
Fan Y, Li D, Qian J, Liu Y and Feng H: Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer. Exp Ther Med 11: 421-426, 2016.
APA
Fan, Y., Li, D., Qian, J., Liu, Y., & Feng, H. (2016). Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer. Experimental and Therapeutic Medicine, 11, 421-426. https://doi.org/10.3892/etm.2015.2933
MLA
Fan, Y., Li, D., Qian, J., Liu, Y., Feng, H."Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer". Experimental and Therapeutic Medicine 11.2 (2016): 421-426.
Chicago
Fan, Y., Li, D., Qian, J., Liu, Y., Feng, H."Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer". Experimental and Therapeutic Medicine 11, no. 2 (2016): 421-426. https://doi.org/10.3892/etm.2015.2933
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