Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report

  • Authors:
    • Guoqing Yang
    • Jingtao Dou
    • Xiaolin Zhang
    • Weijun Gu
    • Zhaohui Lv
    • Jin Du
    • Jianming Ba
    • Yiming Mu
    • Juming Lu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, PLA General Hospital, Beijing 100853, P.R. China
  • Pages: 530-534
    |
    Published online on: December 14, 2015
       https://doi.org/10.3892/etm.2015.2935
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, the case of a female patient with pseudo‑hermaphrodism caused by an androgen‑producing adrenocortical tumor is presented, and the possible mechanism is investigated. The expression of the luteinizing hormone/human chorionic gonadotrophin (LH/hCG) receptor in tumor tissues and normal adrenal tissues was analyzed using immunohistochemistry. Furthermore, the activities of 3β‑hydroxysteroid dehydrogenase 2 (HSD2), cytochrome P450 17α‑hydroxylase (CYP17) and 17β‑hydroxysteroid dehydrogenase 3 (HSD3) enzymes were measured using enzyme‑linked immunosorbent assay, and the expression levels of 3β‑HSD2, 17β‑HSD3, CYP17 and LH/hCG receptor mRNA were determined by quantitative polymerase chain reaction (qPCR). Immunohistochemical staining for the LH/hCG receptor was negative in the tumor tissue and positive in the normal adrenal tissue. The activities of 3β‑HSD2 and CYP17 in the tumor tissue were higher than those in the normal tissue (P<0.01), whereas the activity of 17β‑HSD3 was lower (P<0.01). The mRNA levels of 3β‑HSD2 and CYP17 were higher (P<0.01) and the levels of 17β‑HSD3 and LH/hCG receptor were lower (P<0.01) in the tumor tissue compared with those of the normal tissue. In conclusion, in the present study, a rare case of virilization by an androgen‑producing adrenocortical tumor is present. The results indicate that it may be associated with increased activities of 3β‑HSD2 and CYP17 but not with the expression of the LH/hCG receptor.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Rohana AG, Ming W, Norlela S and Norazmi MK: Functioning adrenal adenoma in association with congenital adrenal hyperplasia. Med J Malaysia. 62:158–159. 2007.PubMed/NCBI

2 

Bédrine H D.M..Mangeot JP and Bégueri F: Familial male pseudo-hermaphrodism of karyotype XY and ambiguous morphology. Gynecol Obstet (Paris). 67:15–28. 1968.(In French). PubMed/NCBI

3 

Ben Charfeddine I, Riepe FG, Kahloul N, Kulle AE, Adala L, Mamaï O, Amara A, Mili A, Amri F, Saad A, Holterhus PM and Gribaa M: Two novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11β hydroxylase deficiency in a Tunisian family. Gen Comp Endocrinol. 175:514–518. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Choukair D, Beuschlein F, Zwermann O, Wudy SA, Haufe S, Holland-Cunz S and Bettendorf M: Virilization of a young girl caused by concomitant ectopic and intra-adrenal adenomas of the adrenal cortex. Horm Res Paediatr. 79:318–322. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Nakamura A, Schimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano H and Koike T: Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome. J Endocrinol Invest. 30:65–69. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Wang S, Kamat A, Pergola P, Swamy A, Tio F and Cusi K: Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo. Metabolism. 60:1090–1099. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Tanaka S, Tanabe A, Aiba M, Hizuka N, Takano K, Zhang J and Young WF: Glucocorticoid- and androgen-secreting black adrenocortical adenomas, unique cause of corticotropin-independent Cushing syndrome. Endocr Pract. 17:e73–e78. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Cordera F, Grant C, van Heerden J, Thompson G and Young W: Androgen-secreting adrenal tumors. Surgery. 134:874–880. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Lipsett MB, Hertz R and Ross GT: Clinical and pathophysiologic aspects of adrenocortical carcinoma. Am J Med. 35:374–383. 1963. View Article : Google Scholar : PubMed/NCBI

10 

Fukushima DK and Gallagher TF: Steroid Production in ‘Nonfunctioning’ Adrenal Cortical Tumor: J Clin Endocrinol Metab. 23:923–927. 1963.

11 

Kim BY, Chun AR, Kim KJ, Jung CH, Kang SK, Mok JO and Kim CH: Clinical characteristics and metabolic features of patients with adrenal incidentalomas with or without subclinical Cushin's syndrome. Endocrinol Metab (Seoul). 29:457–463. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Rodríguez-Gutiérrez R, Bautista-Medina MA, Teniente-Sanchez AE, Zapata-Rivera MA and Montes-Villarreal J: Pure androgen-secreting adrenal adenoma associated with resistant hypertension. Case Rep Endocrinol. 2013:3560862013.PubMed/NCBI

13 

Petersons CJ and Burt MG: The utility of adrenal and ovarian venous sampling in the investigation of androgen-secreting tumours. Intern Med J. 41:69–70. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Nguyen PT, Lee RS, Conley AJ, Sneyd J and Soboleva TK: Variation in 3β-hydroxysteroid dehydrogenase activity and in pregnenolone supply rate can paradoxically alter androstenedione synthesis. J Steroid Biochem Mol Biol. 128:12–20. 2012. View Article : Google Scholar : PubMed/NCBI

15 

de Groot JW, Links TP, Themmen AP, Looijenga LH, de Krijger RR, van Koetsveld PM, Hofland J, van den Berg G, Hofland LJ and Feelders RA: Aberrant expression of multiple hormone receptors in ACTH-independent macronodular adrenal hyperplasia causing Cushing's syndrome. Eur J Endocrinol. 163:293–299. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Rask E, Schvarcz E, Hellman P, Hennings J, Karlsson FA and Rao CV: Adrenocorticotropin-independent Cushing's syndrome in pregnancy related to overexpression of adrenal luteinizing hormone/human chorionic gonadotropin receptors. J Endocrinol Invest. 32:313–316. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Morris LF, Park S, Daskivich T, Churchill BM, Rao CV, Lei Z, Martinez DS and Yeh MW: Virilization of a female infant by a maternal adrenocortical carcinoma. Endocr Pract. 17:e26–e31. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Fujieda K and Ito Y: Inactivating and activating mutations of the human LH/hCG receptor leading to male pseudohermaphroditism and familial male-limited precocious puberty. Nihon Rinsho. 60:265–271. 2002.(In Japanese). PubMed/NCBI

19 

Lai KP, Huang CK, Fang LY, Izumi K, Lo CW, Wood R, Kindblom J, Yeh S and Chang C: Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH). Mol Endocrinol. 27:1617–1631. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Mieritz MG, Sorensen K, Aksglaede L, Mouritsen A, Hagen CP, Hilsted L, Andersson AM and Juul A: Elevated serum IGF-I, but unaltered sex steroid levels, in healthy boys with pubertal gynaecomastia. Clin Endocrinol (Oxf). 80:691–698. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Monroe WE, Panciera D and Zimmerman KL: Concentrations of noncortisol adrenal steroids in response to ACTH in dogs with adrenal-dependent hyperadrenocorticism, pituitary-dependent hyperadrenocorticism, and nonadrenal illness. J Vet Intern Med. 26:945–952. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang G, Dou J, Zhang X, Gu W, Lv Z, Du J, Ba J, Mu Y and Lu J: Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. Exp Ther Med 11: 530-534, 2016.
APA
Yang, G., Dou, J., Zhang, X., Gu, W., Lv, Z., Du, J. ... Lu, J. (2016). Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. Experimental and Therapeutic Medicine, 11, 530-534. https://doi.org/10.3892/etm.2015.2935
MLA
Yang, G., Dou, J., Zhang, X., Gu, W., Lv, Z., Du, J., Ba, J., Mu, Y., Lu, J."Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report". Experimental and Therapeutic Medicine 11.2 (2016): 530-534.
Chicago
Yang, G., Dou, J., Zhang, X., Gu, W., Lv, Z., Du, J., Ba, J., Mu, Y., Lu, J."Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report". Experimental and Therapeutic Medicine 11, no. 2 (2016): 530-534. https://doi.org/10.3892/etm.2015.2935
Copy and paste a formatted citation
x
Spandidos Publications style
Yang G, Dou J, Zhang X, Gu W, Lv Z, Du J, Ba J, Mu Y and Lu J: Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. Exp Ther Med 11: 530-534, 2016.
APA
Yang, G., Dou, J., Zhang, X., Gu, W., Lv, Z., Du, J. ... Lu, J. (2016). Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. Experimental and Therapeutic Medicine, 11, 530-534. https://doi.org/10.3892/etm.2015.2935
MLA
Yang, G., Dou, J., Zhang, X., Gu, W., Lv, Z., Du, J., Ba, J., Mu, Y., Lu, J."Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report". Experimental and Therapeutic Medicine 11.2 (2016): 530-534.
Chicago
Yang, G., Dou, J., Zhang, X., Gu, W., Lv, Z., Du, J., Ba, J., Mu, Y., Lu, J."Increased 3β‑hydroxysteroid dehydrogenase 2 and 17α‑hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report". Experimental and Therapeutic Medicine 11, no. 2 (2016): 530-534. https://doi.org/10.3892/etm.2015.2935
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team