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Article

Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy

  • Authors:
    • Ya‑Li Ge
    • Xiaobo Li
    • Ju Gao
    • Xicheng Zhang
    • Xiangzhi Fang
    • Luojing Zhou
    • Wei Ji
    • Shunyan Lin
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China, Department of Neurology, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China, Department of Vascular Surgery, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China, Department of Scientific Research, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China
  • Pages: 1128-1134
    |
    Published online on: January 11, 2016
       https://doi.org/10.3892/etm.2016.2978
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Abstract

The present study aimed to investigate the effects of dexmedetomidine (DEX) on cognition following a carotid endarterectomy (CEA). In addition, the neuroprotective effects of DEX against ischemia-reperfusion injury during CEA were analyzed. Patients due to undergo elective CEA under general anesthesia were randomly assigned to either the DEX‑treated group (group D; n=25) or the control group (group C; n=25). Patients in group D were treated with 0.3 µg/kg DEX pre‑CEA, followed by 0.3 µg/kg/h DEX intraoperatively up to 30 min prior to the completion of surgery, and the patients in group C received an equal volume of normal saline. Cognitive function was assessed prior to CEA (T0), and at 24, 48, and 72 h, 7 days and 1 month post‑surgery (T1‑5, respectively), using the Mini‑Mental State Examination (MMSE). Blood samples were drawn from the ipsilateral jugular bulb of all patients at 20 min prior to anesthesia (t0), and at 10 min following tracheal intubation, 15 min following clamping and unclamping of the carotid artery, and at 6 and 24 h postoperatively (t1‑5, respectively). The protein expression levels of markers of cerebral ischemia and injury, namely S100 calcium‑binding protein B (S100B) and neuron‑specific enolase (NSE), and the concentration of the oxidative stress marker malondialdehyde (MDA), were analyzed. Patients in group D exhibited elevated MMSE scores at T2 and T3 post‑CEA, as compared with group C. Furthermore, the protein expression level of S100B and the concentration of MDA in the jugular bulb of group D patients were markedly decreased compared with those in group C at t3‑5 and t3, respectively. The results of the present study suggested that DEX was able to enhance the recovery of cognition following CEA, and this was associated with decreased cerebral damage and antioxidative effects.
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Copy and paste a formatted citation
Spandidos Publications style
Ge YL, Li X, Gao J, Zhang X, Fang X, Zhou L, Ji W and Lin S: Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy. Exp Ther Med 11: 1128-1134, 2016.
APA
Ge, Y., Li, X., Gao, J., Zhang, X., Fang, X., Zhou, L. ... Lin, S. (2016). Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy. Experimental and Therapeutic Medicine, 11, 1128-1134. https://doi.org/10.3892/etm.2016.2978
MLA
Ge, Y., Li, X., Gao, J., Zhang, X., Fang, X., Zhou, L., Ji, W., Lin, S."Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy". Experimental and Therapeutic Medicine 11.3 (2016): 1128-1134.
Chicago
Ge, Y., Li, X., Gao, J., Zhang, X., Fang, X., Zhou, L., Ji, W., Lin, S."Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1128-1134. https://doi.org/10.3892/etm.2016.2978
Copy and paste a formatted citation
x
Spandidos Publications style
Ge YL, Li X, Gao J, Zhang X, Fang X, Zhou L, Ji W and Lin S: Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy. Exp Ther Med 11: 1128-1134, 2016.
APA
Ge, Y., Li, X., Gao, J., Zhang, X., Fang, X., Zhou, L. ... Lin, S. (2016). Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy. Experimental and Therapeutic Medicine, 11, 1128-1134. https://doi.org/10.3892/etm.2016.2978
MLA
Ge, Y., Li, X., Gao, J., Zhang, X., Fang, X., Zhou, L., Ji, W., Lin, S."Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy". Experimental and Therapeutic Medicine 11.3 (2016): 1128-1134.
Chicago
Ge, Y., Li, X., Gao, J., Zhang, X., Fang, X., Zhou, L., Ji, W., Lin, S."Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy". Experimental and Therapeutic Medicine 11, no. 3 (2016): 1128-1134. https://doi.org/10.3892/etm.2016.2978
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