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Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values

  • Authors:
    • Zeina Akiki
    • Dalia Fakih
    • Rania Jounblat
    • Soulaima Chamat
    • Mirna Waked
    • Uffe Holmskov
    • Grith L. Sorensen
    • Rachel Nadif
    • Pascale Salameh
  • View Affiliations / Copyright

    Affiliations: INSERM, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, U1168, F‑94807 Villejuif, France, Laboratory of Immunology, Faculty of Public Health, Doctoral School for Sciences and Technology, Lebanese University, 90656 Jdeidet El Metn, Lebanon, Saint George Hospital University Medical Center, Beirut 1100‑2807, Lebanon, Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, DK‑5000 Odense C, Denmark
    Copyright: © Akiki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 723-730
    |
    Published online on: January 13, 2016
       https://doi.org/10.3892/etm.2016.2986
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Abstract

Biological markers can help to better identify a disease or refine its diagnosis. In the present study, the association between surfactant protein D (SP‑D) and chronic obstructive pulmonary disease (COPD) was studied among subjects consulting for respiratory diseases or symptoms and was compared with C‑reactive protein (CRP) and fibrinogen. A further aim of this study was to identify the optimal cut‑off point of SP‑D able to discriminate COPD patients. A case‑control study including 90 COPD patients, 124 asthma patients and 180 controls was conducted. Standardized questionnaires were administered and lung function tests were performed. Biological markers were measured in blood samples according to standardized procedures. The association between SP‑D and COPD was investigated using logistic regression models. Receiver‑operating characteristic curves were used for threshold identification. SP‑D levels above the median value were positively associated with COPD [adjusted odds ratio (OR)=3.86, 95% confidence interval (CI): 1.51‑9.85, P=0.005). No associations with COPD or asthma were found for CRP or fibrinogen levels. Scores for COPD diagnosis in all COPD patients or ever‑smoker COPD patients were identified (sensitivity, 76.4 and 77.8%; specificity, 89.3 and 88.5%, respectively). The results indicate that SP‑D can differentiate COPD from other respiratory symptoms or diseases. Used with socio‑demographic characteristics and respiratory symptoms, SP‑D is able to discriminate COPD patients from controls, particularly among smokers.
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Copy and paste a formatted citation
Spandidos Publications style
Akiki Z, Fakih D, Jounblat R, Chamat S, Waked M, Holmskov U, Sorensen GL, Nadif R and Salameh P: Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values. Exp Ther Med 11: 723-730, 2016.
APA
Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Holmskov, U. ... Salameh, P. (2016). Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values. Experimental and Therapeutic Medicine, 11, 723-730. https://doi.org/10.3892/etm.2016.2986
MLA
Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Holmskov, U., Sorensen, G. L., Nadif, R., Salameh, P."Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values". Experimental and Therapeutic Medicine 11.3 (2016): 723-730.
Chicago
Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Holmskov, U., Sorensen, G. L., Nadif, R., Salameh, P."Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values". Experimental and Therapeutic Medicine 11, no. 3 (2016): 723-730. https://doi.org/10.3892/etm.2016.2986
Copy and paste a formatted citation
x
Spandidos Publications style
Akiki Z, Fakih D, Jounblat R, Chamat S, Waked M, Holmskov U, Sorensen GL, Nadif R and Salameh P: Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values. Exp Ther Med 11: 723-730, 2016.
APA
Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Holmskov, U. ... Salameh, P. (2016). Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values. Experimental and Therapeutic Medicine, 11, 723-730. https://doi.org/10.3892/etm.2016.2986
MLA
Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Holmskov, U., Sorensen, G. L., Nadif, R., Salameh, P."Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values". Experimental and Therapeutic Medicine 11.3 (2016): 723-730.
Chicago
Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Holmskov, U., Sorensen, G. L., Nadif, R., Salameh, P."Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values". Experimental and Therapeutic Medicine 11, no. 3 (2016): 723-730. https://doi.org/10.3892/etm.2016.2986
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