Single-center study on transplantation of livers donated after cardiac death: A report of 6 cases

Sun,Xu‑Yong; Dong,Jian‑Hui; Qin,Ke; Lan,Liu‑Gen; Li,Hai‑Bin; Huang,Ying; Cao,Song; Li,Zhuang‑Jiang; Dai,Long‑Jun

doi:10.3892/etm.2016.3001

Single-center study on transplantation of livers donated after cardiac death: A report of 6 cases

Authors:
- Xu‑Yong Sun
- Jian‑Hui Dong
- Ke Qin
- Liu‑Gen Lan
- Hai‑Bin Li
- Ying Huang
- Song Cao
- Zhuang‑Jiang Li
- Long‑Jun Dai
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Affiliations: Guangxi Key Laboratory for Transplantation Medicine, Institute of Transplant Medicine, 303 Hospital of People's Liberation Army, Nanning, Guangxi 530021, P.R. China
Published online on: January 15, 2016 https://doi.org/10.3892/etm.2016.3001
Pages: 988-992

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Abstract

Effective use of all available donated organs is critical, in order to meet the increasing demand for transplants. The present study explored liver transplantation with livers that were donated following cardiac death (DCD). According to the guidelines established by The Red Cross Society of China, 42 DCD organs were procured. Selected donors were treated with extracorporeal membrane oxygenation (ECMO) prior to the organ retrieval. The present single‑center study included 6 liver transplantations of DCD organs (5 liver transplants and 1 liver‑kidney combined transplant). All 6 recipients had a successful recovery without significant complications. The serum alanine transaminase, total bilirubin and international normalized ratio returned to the normal levels within a short period of time following transplantation, and the liver function remained normal during the follow‑up period, which lasted up to 24 months. The present report demonstrated the feasibility of orthotopic liver transplantation using DCD livers. The pre‑conditioning DCD donors and optimization of the recipient's condition using ECMO, played a crucial role in ensuring the success of transplantation.

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