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An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency

  • Authors:
    • Ying Xue
    • Yiqing Gao
    • Shuqin Wang
    • Pei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1647-1652
    |
    Published online on: February 19, 2016
       https://doi.org/10.3892/etm.2016.3091
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Abstract

The aim of the present study was to examine the effects of different doses of recombinant human growth hormone (rhGH) on children with growth hormone deficiency (GHD) and on thyroid and glucose metabolism to identify more reasonable therapeutic doses of growth hormone (GH) for the treatment of this condition. In total, 60 prepubertal patients with GHD were randomly divided into the high-dose and low-dose groups (n=30 per group). The groups were treated with 0.1 or 0.05 U/kg for 6 months, respectively. The follow‑up study focused on changes to the serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein (IGFBP)-3, blood glucose, thyroid hormone [triiodothyronine (T3) and its prohormone, thyroxine (T4), and thyroid stimulating hormone (TSH)] and the analysis of variance of the repeated data. Changes in the height, body weight and bone age of the high-dose group were greater than those of the low-dose group. After 6 months of treatment, the difference in height between the two groups was statistically significant (P<0.05). Glucose metabolism in the two groups was consistent, but there was a statistically significant difference in the fasting blood glucose (FBG) levels of the two groups after 6 months of treatment (P<0.05). Prior to treatment, the T3, T4 and TSH values (the thyroid function tests) in the two groups, especially for the value of T3 in high-dose group were varied. However, 6 months after treatment, statistically significant differences between the two groups (P<0.05) were identified. In conclusion, 0.1 U/kg of GH is beneficial to children with GHD in attaining a satisfactory height, but it leads to insulin resistance. Thus, glucose metabolism and thyroid function should be monitored on a regular basis in a clinical setting.
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1 

Austin DE, Gunn AJ and Jefferies CA: Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency. Oxf Med Case Rep. 2015:211–214. 2015. View Article : Google Scholar

2 

Valença EH, Salvatori R, Souza AH, Oliveira-Neto LA, Oliveira AH, Gonçalves MI, Oliveira CR, DÁvila JS, Melo VA, de Carvalho S, et al: Voice formants in individuals with congenital, isolated, lifetime growth hormone deficiency. J Voice: pii: S0892-1997(15)00057-0. 2015.(Epub ahead of print). View Article : Google Scholar

3 

Netchine I, Talon P, Dastot F, Vitaux F, Goossens M and Amselem S: Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene. J Clin Endocrinol Metab. 83:432–436. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Bao XL, Shi YF, Du YC, Liu R, Deng JY and Gao SM: Prevalence of growth hormone deficiency of children in Beijing. Chin Med J (Engl). 105:401–405. 1992.PubMed/NCBI

5 

Blethen SL, Allen DB and Graves D: Safety of recombinantdeoxyribonucleic acid-derived growth hormone: The National Cooperative Growth Study experience. J Clin Endocrinol Metab. 81:1704–1710. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Frindik JP and Baptista J: Adult height in growth hormone deficiency: historical perspective and examples from the national cooperative growth study. Pediatrics. 104:1000–1004. 1999.PubMed/NCBI

7 

Root AW, Kemp SF and Rundle AC: Effect of long-term recombinant growth hormone therapy in children - the National Cooperative Growth Study. J Pediatr Endocrinol Metab. 11:403–412. 1998.PubMed/NCBI

8 

Famini P, Maya MM and Melmed S: Pituitary magnetic resonance imaging for sellar and parasellar masses: Ten-year experience in 2598 patients. J Clin Endocrinol Metab. 96:1633–1641. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Obara-Moszyńska M and Niedziela M: The usefulness of the GHRH stimulation test in the diagnostics of growth hormone deficiency in children. Endokrynol Pol. 66:137–141. 2015. View Article : Google Scholar : PubMed/NCBI

10 

de Paula FJ, Góis-Júnior MB, Aguiar-Oliveira MH, Pereira Fde A, Oliveira CR, Pereira RM, Farias CT, Vicente TA and Salvatori R: Consequences of lifetime isolated growth hormone (GH) deficiency and effects of short-term GH treatment on bone in adults with a mutation in the GHRH-receptor gene. J Clin Endocrinol (Oxf). 70:35–44. 2009. View Article : Google Scholar

11 

Alcântara MR, Salvatori R, Alcântara PR, Nóbrega LM, Campos VS, Oliveira EC, Oliveira MH, Souza AH and Aguiar-Oliveira MH: Thyroid morphology and function in children with untreated isolated growth hormone deficiency. J Clin Endocrinol Metab. 91:364–371. 2013.

12 

Tanner JM, Whitehouse RH and Takaishi M: Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I. Arch Dis Child. 41:454–471. 1966. View Article : Google Scholar : PubMed/NCBI

13 

Oliveira JL, Aguiar-Oliveira MH, D'Oliveira A Jr, Pereira RM, Oliveira CR, Farias CT, Barreto-Filho JA, Anjos-Andrade FD, Marques-Santos C, Nascimento-Junior AC, et al: Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults. J Clin Endocrinol Metab. 92:4664–4670. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Deal CL, Tony M, Höybye C and David B: Allen, Maïthé Tauber and Jens Christiansen JB: Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome. J Clin Endocrinol Metab. 98:E1072–E10872013. View Article : Google Scholar

15 

Kalina-Faska B, Kalina M and Koehler B: Effects of recombinant growth hormone therapy on thyroid hormone concentrations. Int J Clin Pharmacol Ther. 42:30–34. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Growth Hormone Research Society: Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab. 85:3990–3993. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Ranke MB, Lindberg A, Price DA, Darendeliler F, Albertsson-Wikland K, Wilton P and Reiter EO: KIGS International Board: Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature. Horm Res. 68:53–62. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Kawa MP, Stecewicz I, Piecyk K, Pius-Sadowska E, Paczkowska E, Rogińska D, Sobuś A, Łuczkowska K, Gawrych E, Petriczko E, et al: Effects of growth hormone therapeutic supplementation on hematopoietic stem/progenitor cells in children with growth hormone deficiency: focus on proliferation and differentiation capabilities. Endocrine. Apr 29–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

19 

Chaplin JE, Kriström B, Jonsson B, Tuvemo T and Albertsson-Wikland K: Growth hormone treatment improves cognitive function in short children with growth hormone deficiency. Horm Res Paediatr. Mar 25–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

20 

Davis NL, Stewart CE, Moss AD, Woltersdorf WW, Hunt LP, Elson RA, Cornish JM, Stevens MC and Crowne EC: Growth hormone deficiency after childhood bone marrow transplantation with total body irradiation: interaction with adiposity and age. Clin Endocrinol (Oxf). Mar 21–2015.(Epub ahead of print). View Article : Google Scholar

21 

Rose SR, Municchi G, Barnes KM, Kamp GA, Uriarte MM, Ross JL, Cassorla F and Cutler GB Jr: Spontaneous growth hormone secretion increases during puberty in normal girls and boys. J Clin Endocrinol Metab. 73:428–435. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Sverrisdóttir YBI, Elam M, Caidahl K, Söderling AS, Herlitz H and Johannsson G: The effect of growth hormone (GH) replacement therapy on sympathetic nerve hyperactivity in hypopituitary adults: a double-blind, placebo-controlled, crossover, short-term trial followed by long-term open GH replacement in hypopituitary adults. J Hypertens. 21:1905–1914. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Poyrazoğlu Ş, Akçay T, Arslanoğlu İ, Atabek ME, Atay Z, Berberoğlu M, Bereket A, Bideci A, Bircan İ, Böber E, et al: Current practice in diagnosis and treatment of growth hormone deficiency in childhood: A survey from Turkey. J Clin Res Pediatr Endocrinol. 7:37–44. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Tornese G, Marzuillo P, Pellegrin MC, Germani C, Faleschini E, Zennaro F, Grandone A, Del Giudice Miraglia E, Perrone L and Ventura A: A case of Rubinstein-Taybi syndrome associated with growth hormone deficiency in childhood. Clin Endocrinol (Oxf). Feb 14–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

25 

Bramnert M, Segerlantz M, Laurila E, Daugaard JR, Manhem P and Groop L: Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle. J Clin Endocrinol Metab. 88:1455–1463. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Deepak D, Daousi C, Javadpour M, Clark D, Perry Y, Pinkney J and Macfarlane IA: The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency. Growth Horm IGF Res. 20:220–225. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Eugster EA, Fisch M, Walvoord EC, DiMeglio LA and Pescovitz OH: Low hemoglobin levels in children with in idiopathic growth hormone deficiency. Endocrine. 18:135–136. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Altomare F, Rubino M and Matarazzo P: Correlation between IGF-1 serum level and hemoglobin concentration in children with idiopathic growth hormone deficiency (IGHD). J Pediatr. 11:885–889. 2012.

29 

Sohmiya M and Kato Y: Effect long-term treatment with recombinant human growth hormone on erythropoietin secretion in an anemic patient with panhypopituitarism. J Endocrinol Invest. 36:331–336. 2010.

30 

Cohen PI, Germak J, Rogol AD, Weng W, Kappelgaard AM and Rosenfeld RG: American Norditropin Study Group: Variable degree of growth hormone (GH) and insulin-like growth factor(IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children. J Clin Endocrinol Metab. 95:2089–2098. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Møller N and Jørgensen JO: Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 30:152–177. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Child CJ, Zimmermann AG, Scott RS, Cutler GB Jr, Battelino T and Blum WF: GeNeSIS International Advisory Board: Prevalence and incidence of diabetes mellitus in GH-treated children and adolescents: analysis from the GeNeSIS observational research program. J Clin Endocrinol Metab. 96:E1025–E1034. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Mauras NI, Attie KM, Reiter EO, Saenger P and Baptista J: High dose recombinant human growth hormone (GH) treatment of GH-deficient patients in puberty increases hear-final height: a randomized, multicenter trial. J Clin Endocrinol Metab. 85:3653–3660. 2010. View Article : Google Scholar

34 

Coelho R, Brook CG, Preece MA, Stanhope RG, Dattani MT and Hindmarsh PC: A randomised study of two doses of biosynthetic human growth hormone on final height of pubertal children with growth hormone deficiency. Horm Res. 70:85–88. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xue Y, Gao Y, Wang S and Wang P: An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. Exp Ther Med 11: 1647-1652, 2016.
APA
Xue, Y., Gao, Y., Wang, S., & Wang, P. (2016). An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. Experimental and Therapeutic Medicine, 11, 1647-1652. https://doi.org/10.3892/etm.2016.3091
MLA
Xue, Y., Gao, Y., Wang, S., Wang, P."An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency". Experimental and Therapeutic Medicine 11.5 (2016): 1647-1652.
Chicago
Xue, Y., Gao, Y., Wang, S., Wang, P."An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1647-1652. https://doi.org/10.3892/etm.2016.3091
Copy and paste a formatted citation
x
Spandidos Publications style
Xue Y, Gao Y, Wang S and Wang P: An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. Exp Ther Med 11: 1647-1652, 2016.
APA
Xue, Y., Gao, Y., Wang, S., & Wang, P. (2016). An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. Experimental and Therapeutic Medicine, 11, 1647-1652. https://doi.org/10.3892/etm.2016.3091
MLA
Xue, Y., Gao, Y., Wang, S., Wang, P."An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency". Experimental and Therapeutic Medicine 11.5 (2016): 1647-1652.
Chicago
Xue, Y., Gao, Y., Wang, S., Wang, P."An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1647-1652. https://doi.org/10.3892/etm.2016.3091
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