CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy

  • Authors:
    • Qingxiao Hong
    • Yirun Li
    • Xiaoying Chen
    • Huadan Ye
    • Linlin Tang
    • Annan Zhou
    • Yan Hu
    • Yuting Gao
    • Rongrong Chen
    • Yongming Xia
    • Shiwei Duan
  • View Affiliations

  • Published online on: February 19, 2016     https://doi.org/10.3892/etm.2016.3092
  • Pages: 1901-1907
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Abstract

Previous studies have demonstrated that promoter hypermethylation of tumor suppressor genes contributes to the occurrence and development of acute myeloid leukemia (AML). However, the association of DNA methylation with chemotherapeutic outcomes remains unknown. In the present study, 15 patients with AML were recruited, and the promoter methylation status of cyclin‑dependent kinase inhibitor 2B (CDKN2B), solute carrier family 19 member 3 (SLC19A3) and deleted in lung and esophageal cancer 1 (DLEC1) genes was examined prior to and following various chemotherapeutic regimens in order to identify any alterations. The results suggested that chemotherapy‑induced hypermethylation of CDKN2B and DLEC1 may be specific to males and females, respectively, and that there were no alterations in SLC19A3 methylation following chemotherapy. These results may provide an improved understanding of gene methylation to guide the development of an individualized chemotherapy for AML. Due to the complexity of AML and the wide range of treatment types, future studies with a larger sample size are required in order to verify the results of the present investigation.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hong Q, Li Y, Chen X, Ye H, Tang L, Zhou A, Hu Y, Gao Y, Chen R, Xia Y, Xia Y, et al: CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy. Exp Ther Med 11: 1901-1907, 2016
APA
Hong, Q., Li, Y., Chen, X., Ye, H., Tang, L., Zhou, A. ... Duan, S. (2016). CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy. Experimental and Therapeutic Medicine, 11, 1901-1907. https://doi.org/10.3892/etm.2016.3092
MLA
Hong, Q., Li, Y., Chen, X., Ye, H., Tang, L., Zhou, A., Hu, Y., Gao, Y., Chen, R., Xia, Y., Duan, S."CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy". Experimental and Therapeutic Medicine 11.5 (2016): 1901-1907.
Chicago
Hong, Q., Li, Y., Chen, X., Ye, H., Tang, L., Zhou, A., Hu, Y., Gao, Y., Chen, R., Xia, Y., Duan, S."CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the bone marrow of patients with acute myeloid leukemia during chemotherapy". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1901-1907. https://doi.org/10.3892/etm.2016.3092