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Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus

  • Authors:
    • Zhihong Nie
    • Limin Xu
    • Chuanyuan Li
    • Tao Tian
    • Pingping Xie
    • Xia Chen
    • Bojing Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Gongli Hospital, The Second Military Medicine University, Shanghai 200135, P.R. China, Department of Laboratory Medicine, Gongli Hospital, The Second Military Medicine University, Shanghai 200135, P.R. China
    Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1581-1586
    |
    Published online on: February 26, 2016
       https://doi.org/10.3892/etm.2016.3114
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Abstract

The present study aimed to investigate the association between endothelial progenitor cells (EPCs) and peptic ulcers in patients with or without type 2 diabetes mellitus (T2DM), in association with the efficiency of peptic ulcer treatment. The study recruited healthy subjects and peptic ulcer patients with or without T2DM. All the ulcer patients, including those with and without T2DM, were administered omeprazole for 8 weeks. Peptic ulcer patients with T2DM were additionally treated with glipizide and novolin. Blood samples were then obtained from the three groups following ulcer treatment. CD133+ cells were isolated from the blood samples using magnetic bead selection, and cultured in complete medium 199. Morphological and quantity changes in EPCs were observed by light and fluorescence microscopy. In addition, flow cytometric analysis was used to quantify the number of vascular endothelial cells. The treatment was partially effective in 7 of the 32 peptic ulcer patients without T2DM and 12 of the 32 peptic ulcer patients with T2DM. However, this treatment was ineffective in 20 of the 32 peptic ulcer patients with T2DM. Notably, 25 peptic ulcer patients without T2DM were defined as completely recovered following treatment. In addition, the number of circulating EPCs as well as their colony forming ability was significantly reduced (P<0.05) in the peptic ulcer patients with T2DM following ulcer treatment, compared with the other groups. Circulating EPC counts were significantly increased in peptic ulcer patients without T2DM, as compared with the healthy controls. With regards to colony formation, peptic ulcer patients without T2DM did not exhibit improved colony formation ability. In conclusion, the number of circulating EPCs and their colony‑forming ability was significantly reduced in peptic ulcer patients with T2DM following ulcer treatment when compared with the other groups. This suggests that the poor curative effect of peptic ulcer treatment in these patients is associated with impairment of EPCs.
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1 

Tacheci I and Bures J: Peptic ulcer disease in patients with diabetes mellitus. Vnitr Lek. 57:347–350. 2011.(In Czech). PubMed/NCBI

2 

Najm WI: Peptic ulcer disease. Prim Care. 38:383–394. 2011. View Article : Google Scholar : PubMed/NCBI

3 

GBD 2013 Mortality and Causes of Death Collaborators: Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 385:117–171. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Dey L, Attele AS and Yuan CS: Alternative therapies for type 2 diabetes. Altern Med Rev. 7:45–58. 2002.PubMed/NCBI

5 

Lorenzi M: Glucose toxicity in the vascular complications of diabetes: The cellular perspective. Diabetes Metab Rev. 8:85–103. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Urbich C and Dimmeler S: Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res. 95:343–353. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M and Nickenig G: Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 353:999–1007. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Fadini GP, Miorin M, Facco M, Bonamico S, Baesso I, Grego F, Menegolo M, de Kreutzenberg SV, Tiengo A, Agostini C and Avogaro A: Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol. 45:1449–1457. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Tecilazich F, Dinh T, Pradhan-Nabzdyk L, Leal E, Tellechea A, Kafanas A, Gnardellis C, Magargee ML, Dejam A, Toxavidis V, et al: Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. PLoS One. 8:e833142013. View Article : Google Scholar : PubMed/NCBI

10 

Alberti KG and Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 15:539–553. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Editorial Board of Chinese Journal of Digestion: Suggestion on standardized diagnosis and treatment of peptic ulcer disease (2008, Huang Shah). Zhong Hua Xiao Hua Za Zhi. 28:447–450. 2008.(In Chinese).

12 

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G and Isner JM: Isolation of putative progenitor endothelial cells for angiogenesis. Science. 275:964–967. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Hirschi KK, Ingram DA and Yoder MC: Assessing identity, phenotype and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 28:1584–1595. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Bertolini F, Mancuso P, Braidotti P, Shaked Y and Kerbel RS: The multiple personality disorder phenotype(s) of circulating endothelial cells in cancer. Biochim Biophys Acta. 1796:27–32. 2009.PubMed/NCBI

15 

Tarnawski AS: Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci. 50(Suppl 1): S24–S33. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Schmidt-Lucke C, Rössig L, Fichtlscherer S, Vasa M, Britten M, Kämper U, Dimmeler S and Zeiher AM: Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair. Circulation. 111:2981–2987. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Hristov M, Erl W and Weber PC: Endothelial progenitor cells: Mobilization, differentiation and homing. Arterioscler Thromb Vasc Biol. 23:1185–1189. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Brunner S, Hoellerl F, Schmid-Kubista KE, Zeiler F, Schernthaner G, Binder S and Schernthaner GH: Circulating angiopoietic cells and diabetic retinopathy in type 2 diabetes mellitus, with or without macrovascular disease. Invest Ophthalmol Vis Sci. 52:4655–4662. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Li M, Ho JC, Lai KW, Au KK, Xu A, Cheung BM, Lam KS and Tse HF: The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia. Diabetes Metab Res Rev. 27:185–194. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Leeper NJ, Hunter AL and Cooke JP: Stem cell therapy for vascular regeneration: Adult, embryonic, and induced pluripotent stem cells. Circulation. 122:517–526. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Tang YL, Zhao Q, Qin X, Shen L, Cheng L, Ge J and Phillips MI: Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg. 80:229–237. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Rafii S and Lyden D: Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med. 9:702–712. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G and Isner JM: Isolation of putative progenitor endothelial cells for angiogenesis. Science. 275:964–967. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Sen S, McDonald SP, Coates PT and Bonder CS: Endothelial progenitor cells: Novel biomarker and promising cell therapy for cardiovascular disease. Clin Sci (Lond). 120:263–283. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C and Chen YF: Endothelial progenitor cells: Therapeutic perspective for ischemic stroke. CNS Neurosci Ther. 19:67–75. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nie Z, Xu L, Li C, Tian T, Xie P, Chen X and Li B: Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus. Exp Ther Med 11: 1581-1586, 2016.
APA
Nie, Z., Xu, L., Li, C., Tian, T., Xie, P., Chen, X., & Li, B. (2016). Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 11, 1581-1586. https://doi.org/10.3892/etm.2016.3114
MLA
Nie, Z., Xu, L., Li, C., Tian, T., Xie, P., Chen, X., Li, B."Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 11.5 (2016): 1581-1586.
Chicago
Nie, Z., Xu, L., Li, C., Tian, T., Xie, P., Chen, X., Li, B."Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1581-1586. https://doi.org/10.3892/etm.2016.3114
Copy and paste a formatted citation
x
Spandidos Publications style
Nie Z, Xu L, Li C, Tian T, Xie P, Chen X and Li B: Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus. Exp Ther Med 11: 1581-1586, 2016.
APA
Nie, Z., Xu, L., Li, C., Tian, T., Xie, P., Chen, X., & Li, B. (2016). Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 11, 1581-1586. https://doi.org/10.3892/etm.2016.3114
MLA
Nie, Z., Xu, L., Li, C., Tian, T., Xie, P., Chen, X., Li, B."Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 11.5 (2016): 1581-1586.
Chicago
Nie, Z., Xu, L., Li, C., Tian, T., Xie, P., Chen, X., Li, B."Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1581-1586. https://doi.org/10.3892/etm.2016.3114
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