Advances in neonatal screening for primary immune deficiencies (Review)

Jiang,Tingting; Li,Zhenguang; Zhang,Qiuli

doi:10.3892/etm.2016.3119

Advances in neonatal screening for primary immune deficiencies (Review)

Authors:
- Tingting Jiang
- Zhenguang Li
- Qiuli Zhang
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Affiliations: Department of Neonatology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China
Published online on: March 1, 2016 https://doi.org/10.3892/etm.2016.3119
Pages: 1542-1544
Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The congenital disorders of immune competence are known as primary immunodeficiencies (PID) and are mainly characterized by a pathological susceptibility to infection. These infections are mostly of time repetitive and drug resistant in nature. The number of infected infants has reached over 200 and is on the increase. Additionally, clinical severity of the disease has been confirmed to be extensive. The increasing number of these severe PIDs is due to the lack of specific as well as efficient management avenues.New assays and concepts for newborn screening of severe primary immune deficiencies are being explored and the present review focused on these new upcoming strategies for improved screening of neonates.

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