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Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels

  • Authors:
    • Yong Jiang
    • Jie Li
    • Yang Liu
    • Weiguo Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116600, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1716-1720
    |
    Published online on: March 2, 2016
       https://doi.org/10.3892/etm.2016.3125
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Abstract

The present study aimed to evaluate the accuracy of analysis using optimal cut‑off values of plasma D‑dimer levels in the diagnosis of deep vein thrombosis (DVT). A total of 175 orthopedic patients with DVT and 162 patients without DVT were included in the study. Ultrasonic color Doppler imaging was performed on lower limb veins prior to and following orthopedic surgery in order to determine the types of orthopedic conditions that were present. An enzyme‑linked fluorescent assay was performed to detect the expression levels of D‑dimer in plasma, and receiver operating characteristic analysis was performed to predict the occurrence of DVT on the basis of the expression levels of D‑dimer. After surgery, the expression levels of D‑dimer in the plasma of DVT patients were significantly higher in comparison with those in orthopedic patients without DVT (P<0.05). When the patients were divided into subgroups according to the underlying orthopedic condition, the expression levels of D‑dimer in the plasma of each subgroup were higher 1 day after orthopedic surgery in comparison to those prior to surgery (P<0.05). The diagnostic accuracy achieved using combined optimal cut‑off values at 1 and 3 days post‑surgery was significantly higher than the accuracy when using a single optimal cut‑off value (P<0.05). In conclusion, detection of D‑dimer expression levels at 1 day post‑orthopedic surgery may be important in predicting DVT. In addition, the diagnostic accuracy of DVT is significantly increased by analysis using combined optimal cut‑off values of D‑dimer plasma expression levels.
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1 

Lyle CA, Gibson E, Lovejoy AE and Goldenberg NA: Acute prognostic factors for post-thrombotic syndrome in children with limb DVT: a bi-institutional cohort study. Thromb Res. 131:37–41. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Dua A, Neiva S and Sutherland A: Does previous varicose vein surgery alter deep vein thrombosis risk after lower limb arthroplasty? Orthop Surg. 4:222–226. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Shah K, Thevendran G, Younger A and Pinney SJ: Deep-vein thrombosis prophylaxis in foot and ankle surgery: What is the current state of practice? Foot Ankle Spec. 10:101–106. 2015. View Article : Google Scholar

4 

Jeeshan RR, Ahmad M and Graham MTS: Subclavian vein thrombosis following acute internal fixation of a clavicular fracture. Shoulder Elbow. 5:108–110. 2013. View Article : Google Scholar

5 

Wakabayashi H, Hasegawa M, Niimi R, Naito Y, Nakagawa T and Sudo A: Clinical analysis of preoperative deep vein thrombosis risk factors in patients with total hip arthroplasty. Thromb Res. 136:855. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Ozgur ES, Karaca K, Ozye C and Nayci SA: Does anatomic location of deep venous thrombosis affect the clinical findings and course in the patient of pulmonary embolism. Eur Respir J. 38(Suppl 55): 23452011.

7 

Mant MJ, Eurich DT, Russell DB and Majumdar SR: Post-thrombotic syndrome after total hip arthroplasty is uncommon. Acta Orthop. 79:794–799. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Struijk-Mulder MC, Ettema HB, Verheyen CC and Büller HR: Comparing consensus guidelines on thromboprophylaxis in orthopedic surgery. J Thromb Haemost. 8:678–683. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR and Colwell CW: American College of Chest Physicians: Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 133(6 Suppl): S381–S453. 2008. View Article : Google Scholar

10 

Tenna AM, Kappadath S and Stansby G: Diagnostic tests and strategies in venous thromboembolism. Phlebology. 27(Suppl 2): 43–52. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Molugu C, Fisher G, Hirons B, Hughes D and Raftery S: P151 V-DimERS Study - Value of D-Dimers in estimating risk of significant pulmonary embolism and deep vein thrombosis. Thorax. 68(Suppl 3): A1442013. View Article : Google Scholar

12 

Aaron W and Ann V: Is the D-dimer test a viable option for the detection of PE? J Nucl Med. 55:27082014.

13 

Wells P: Overview and comparison of D-dimer assay kits for DVT and PE. Clin Adv Hematol Oncol. 2:1602004.PubMed/NCBI

14 

Lees D, Griffiths P, Paxton C and Wahbi Z: Can D-dimer assay, together with clinical probability predict computed tomography pulmonary angiogram (CTPA) outcomes for pulmonary embolism (PE)? Eur Respir J. 38(Suppl 55): 5822011.

15 

Shimoyama Y, Sawai T, Tatsumi S, Nakahira J and Minami T: Examination of risk factors for deep vein thrombosis following total hip arthroplasty. Masui. 60:897–902. 2011.(In Japanese). PubMed/NCBI

16 

Park Y, Choi H, Kim SH, Kang J, Kang WC, Shin MS and Moon J: Multisite paradoxical embolisms in a patient with patent foramen ovale and pulmonary thromboembolism. Int J Cardiol. 159:e29–e31. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Wu O, Clark P, Lowe GD, Walker ID and Greer IA: Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study Group: Thrombophilia and venous thromboembolism after total hip or knee replacement surgery: A systematic review. J Thromb Haemost. 3:811–813. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Lausen I, Jensen R, Wille-Jørgensen P, Jørgensen L, Rasmussen M, Lyng K, Andersen M and Raaschou H: Colour Doppler flow imaging ultrasonography versus venography as screening method for asymptomatic postoperative deep venous thrombosis. Original. European Journal of Radiology. 20:200–204. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Magnusson MB, Nelzén O, Risberg B and Sivertsson R: A colour Doppler ultrasound study of venous reflux in patients with chronic leg ulcers. European Journal of Vascular and Endovascular Surgery. 21:353–360. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Li J, Liu Y and Zhang W: Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels. Exp Ther Med 11: 1716-1720, 2016.
APA
Jiang, Y., Li, J., Liu, Y., & Zhang, W. (2016). Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels. Experimental and Therapeutic Medicine, 11, 1716-1720. https://doi.org/10.3892/etm.2016.3125
MLA
Jiang, Y., Li, J., Liu, Y., Zhang, W."Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels". Experimental and Therapeutic Medicine 11.5 (2016): 1716-1720.
Chicago
Jiang, Y., Li, J., Liu, Y., Zhang, W."Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1716-1720. https://doi.org/10.3892/etm.2016.3125
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Li J, Liu Y and Zhang W: Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels. Exp Ther Med 11: 1716-1720, 2016.
APA
Jiang, Y., Li, J., Liu, Y., & Zhang, W. (2016). Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels. Experimental and Therapeutic Medicine, 11, 1716-1720. https://doi.org/10.3892/etm.2016.3125
MLA
Jiang, Y., Li, J., Liu, Y., Zhang, W."Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels". Experimental and Therapeutic Medicine 11.5 (2016): 1716-1720.
Chicago
Jiang, Y., Li, J., Liu, Y., Zhang, W."Diagnostic accuracy of deep vein thrombosis is increased by analysis using combined optimal cut‑off values of postoperative plasma D‑dimer levels". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1716-1720. https://doi.org/10.3892/etm.2016.3125
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