Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2016 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2016 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury

  • Authors:
    • Wen‑Sheng Deng
    • Qing Xu
    • Ye Liu
    • Chun‑Hui Jiang
    • Hong Zhou
    • Lei Gu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, P.R. China
  • Pages: 1955-1960
    |
    Published online on: March 15, 2016
       https://doi.org/10.3892/etm.2016.3160
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the effects of melatonin (MT) on liver function and lipid peroxidation following hepatic ischemia-reperfusion injury (IRI). A total of 66 male Sprague-Dawley rats were randomly assigned into three groups: Normal control (N) group, ischemia‑reperfusion (IR) group and the MT‑treated group. A hepatic IRI model was developed by blocking the first porta hepatis, and subsequently restoring hepatic blood inflow after 35 min. Following reperfusion, changes in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were detected by a chemical method at various time points. In the MT group, the MDA levels were significantly reduced (P<0.05) at all time points, as compared with the IR group. Furthermore, SOD activity was significantly increased (P<0.05) in the MT group, as compared with the IR group at all time points; and the levels of GSH in the MT group were significantly higher (P<0.05) than those of the IR group at 2, 4, and 8 h post‑reperfusion. The levels of ALT, AST and LDH were significantly reduced in the MT group at each time point, as compared with that of the IR group (P<0.05). In conclusion, MT exhibits potent antioxidant properties that may create favorable conditions for the recovery of liver function following IRI.
View Figures

Figure 1

View References

1 

Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C and Samson LD: Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci USA. 111:E4878–E4886. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Rao J, Qin J, Qian X, Lu L, Wang P, Wu Z, Zhai Y, Zhang F, Li G and Wang X: Lipopolysaccharide preconditioning protects hepatocytes from ischemia/reperfusion injury (IRI) through inhibiting ATF4-CHOP pathway in mice. PLoS One. 8:e655682013. View Article : Google Scholar : PubMed/NCBI

3 

García JJ, López-Pingarrón L, Almeida-Souza P, Tres A, Escudero P, García-Gil FA, Tan DX, Reiter RJ, Ramírez JM and Bernal-Pérez M: Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: A review. J Pineal Res. 56:225–237. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Acuña-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, López LC, Rosales-Corral S, Tan DX and Reiter RJ: Extrapineal melatonin: Sources, regulation, and potential functions. Cell Mol Life Sci. 71:2997–3025. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Martins PN and Markmann JF: Age-related differences in hepatic ischemia/reperfusion: Gene activation, liver injury, and protective effect of melatonin. J Surg Res. 85:e19–e21. 2013. View Article : Google Scholar

6 

Frich L, Mala T and Gladhaug IP: Hepatic radiofrequency ablation using perfusion electrodes in a pig model: Effect of the Pringle manoeuvre. Eur J Surg Oncol. 32:527–532. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Koh PO: Melatonin prevents hepatic injury-induced decrease in Akt downstream targets phosphorylations. J Pineal Res. 51:214–219. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Aydogan MS, Erdogan MA, Polat A, Yücel A, Ozgül U, Parlakpinar H, Duran ZR, Yildiz A and Durmus M: Protective effects of melatonin and β-d-glucan against liver injury in rats - a comparative study. Adv Clin Exp Med. 22:621–627. 2012.

9 

Kireev R, Bitoun S, Cuesta S, Tejerina A, Ibarrola C, Moreno E, Vara E and Tresguerres JA: Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. Eur J Pharmacol. 701:185–193. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Kireev RA, Cuesta S, Ibarrola C, Bela T, Gonzalez EM, Vara E and Tresguerres JA: Age-related differences in hepatic ischemia/reperfusion: Gene activation, liver injury, and protective effect of melatonin. J Surg Res. 178:922–934. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Kang JW and Lee SM: Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion. J Pineal Res. 53:67–76. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kang JW, Koh EJ and Lee SM: Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. J Pineal Res. 50:403–411. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Selvam NT, Venkatakrishnan V, Dhamodharan R, Murugesan S and Kumar SD: Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats. Ayu. 34:305–308. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Jin LM, Jin SF, Liu YX, Zhou L, Xie HY, Yan S, Xu X and Zheng SS: Ischemic preconditioning enhances hepatocyte proliferation in the early phase after ischemia under hemi-hepatectomy in rats. Hepatobiliary Pancreat Dis Int. 11:521–526. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Pires KM, Lanzetti M, Rueff-Barroso CR, Castro P, Abrahão A, Koatz VL, Valença SS and Porto LC: Oxidative damage in alveolar macrophages exposed to cigarette smoke extract and participation of nitric oxide in redox balance. Toxicol In Vitro. 26:791–798. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Papadopoulos D, Siempis T, Theodorakou E and Tsoulfas G: Hepatic ischemia and reperfusion injury and trauma: Current concepts. Arch Trauma Res. 2:63–70. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Peralta C, Jiménez-Castro MB and Gracia-Sancho J: Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu. J Hepatol. 59:1094–1106. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Jaeschke H and Woolbright BL: Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev (Orlando). 26:103–114. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Jaeschke H: Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol. 284:G15–G26. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Mendes-Braz M, Elias-Miró M, Jiménez-Castro MB, Casillas-Ramírez A, Ramalho FS and Peralta C: The current state of knowledge of hepatic ischemia-reperfusion injury based on its study in experimental models. J Biomed Biotechnol. 2012:2986572012. View Article : Google Scholar : PubMed/NCBI

21 

Bai J, Dong L, Song Z, Ge H, Cai X, Wang G and Liu P: The role of melatonin as an antioxidant in human lens epithelial cells. Free Radic Res. 47:635–642. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Vishwas DK, Mukherjee A, Haldar C, Dash D and Nayak MK: Improvement of oxidative stress and immunity by melatonin: An age dependent study in golden hamster. Exp Gerontol. 48:168–182. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Bandyopadhyay D, Biswas K, Bandyopadhyay U, Reiter RJ and Banerjee RK: Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical. J Pineal Res. 29:143–151. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Dominguez-Rodriguez A and Abreu-Gonzalez P: Myocardial ischemia-reperfusion injury: Possible role of melatonin. World J Cardiol. 2:233–236. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Elias-Miró M, Jiménez-Castro MB, Rodés J and Peralta C: Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radic Res. 47:555–568. 2013. View Article : Google Scholar : PubMed/NCBI

26 

van Golen RF, van Gulik TM and Heger M: Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury. Free Radic Biol Med. 52:1382–1402. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Palladini G, Ferrigno A, Rizzo V, Tarantola E, Bertone V, Freitas I, Perlini S, Richelmi P and Vairetti M: Lung matrix metalloproteinase activation following partial hepatic ischemia/reperfusion injury in rats. ScientificWorldJournal. 2014:8675482014. View Article : Google Scholar : PubMed/NCBI

28 

Parlaktas BS, Atilgan D, Ozyurt H, Gencten Y, Akbas A, Erdemir F and Uluocak N: The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin. Asian J Androl. 16:314–318. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Kerem H, Akdemir O, Ates U, Uyanıkgıl Y, Sezer Demırel E, Bılkay U, Turgut M, Sozmen E and Songur E: The effect of melatonin on a dorsal skin flap model. J Invest Surg. 27:57–64. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Ortiz F, García J A, Acuña-Castroviejo D, Doerrier C, López A, Venegas C, Volt H, Luna-Sánchez M, López LC and Escames G: The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: Inhibition of iNOS and preservation of nNOS. J Pineal Res. 56:71–81. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hernández-Esquivel L, Pavón N, Buelna-Chontal M, González-Pacheco H, Belmont J and Chávez E: Citicoline (CDP-choline) protects myocardium from ischemia/reperfusion injury via inhibiting mitochondrial permeability transition. Life Sci. 96:53–58. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Wang P, Yin L, Liang D, Li C, Ma F and Yue Z: Delayed senescence of apple leaves by exogenous melatonin treatment: Toward regulating the ascorbate-glutathione cycle. J Pineal Res. 53:11–20. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Reiter RJ, Tan DX, Manchester LC and El-Sawi MR: Melatonin reduces oxidant damage and promotes mitochondrial respiration: Implications for aging. Ann NY Acad Sci. 959:238–250. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Lhuillier F, Parmantier P, Goudable J, Crova P, Delafosse B, Annat G, Cespuglio R and Viale JP: Hepatic ischemia is associated with an increase in liver parenchyma nitric oxide that is in part enzyme-independent. Anesthesiology. 98:373–378. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng WS, Xu Q, Liu Y, Jiang CH, Zhou H and Gu L: Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury. Exp Ther Med 11: 1955-1960, 2016.
APA
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., & Gu, L. (2016). Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 11, 1955-1960. https://doi.org/10.3892/etm.2016.3160
MLA
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., Gu, L."Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury". Experimental and Therapeutic Medicine 11.5 (2016): 1955-1960.
Chicago
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., Gu, L."Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1955-1960. https://doi.org/10.3892/etm.2016.3160
Copy and paste a formatted citation
x
Spandidos Publications style
Deng WS, Xu Q, Liu Y, Jiang CH, Zhou H and Gu L: Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury. Exp Ther Med 11: 1955-1960, 2016.
APA
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., & Gu, L. (2016). Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 11, 1955-1960. https://doi.org/10.3892/etm.2016.3160
MLA
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., Gu, L."Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury". Experimental and Therapeutic Medicine 11.5 (2016): 1955-1960.
Chicago
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., Gu, L."Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1955-1960. https://doi.org/10.3892/etm.2016.3160
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team