Subtraction CT angiography for the detection of intracranial aneurysms: A meta-analysis

  • Authors:
    • Tian-Ying Feng
    • Xue-Feng Han
    • Rui Lang
    • Fei Wang
    • Qiong Wu
  • View Affiliations

  • Published online on: March 15, 2016     https://doi.org/10.3892/etm.2016.3166
  • Pages: 1930-1936
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Abstract

The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital subtraction angiography. Data from the studies were used to construct a 2x2 contingency table on a per‑patient basis in ≥5 diseased and 5 non‑diseased patients, with additional data on a per‑aneurysm basis. Overall, subtraction CTA had a pooled sensitivity of 99% [95% confidence interval (CI), 95‑100%] and specificity of 94% (95% CI, 86‑97%) for detecting and ruling out cerebral aneurysms, respectively, on a per‑patient basis. On a per‑aneurysm basis, the pooled sensitivity was 96% (95% CI, 90‑99%), and the specificity was 91% (95% CI, 85‑95%). In conclusion, subtraction CTA is a highly sensitive, specific and non‑inva­sive method for the diagnosis and evaluation of intracranial aneurysms.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Feng T, Han X, Lang R, Wang F and Wu Q: Subtraction CT angiography for the detection of intracranial aneurysms: A meta-analysis. Exp Ther Med 11: 1930-1936, 2016
APA
Feng, T., Han, X., Lang, R., Wang, F., & Wu, Q. (2016). Subtraction CT angiography for the detection of intracranial aneurysms: A meta-analysis. Experimental and Therapeutic Medicine, 11, 1930-1936. https://doi.org/10.3892/etm.2016.3166
MLA
Feng, T., Han, X., Lang, R., Wang, F., Wu, Q."Subtraction CT angiography for the detection of intracranial aneurysms: A meta-analysis". Experimental and Therapeutic Medicine 11.5 (2016): 1930-1936.
Chicago
Feng, T., Han, X., Lang, R., Wang, F., Wu, Q."Subtraction CT angiography for the detection of intracranial aneurysms: A meta-analysis". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1930-1936. https://doi.org/10.3892/etm.2016.3166