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Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance

  • Authors:
    • Jianbin Zhao
    • Jie Ma
    • Xiaoyan Zhang
    • Qing Li
    • Xueping Yang
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2300-2304
    |
    Published online on: March 23, 2016
       https://doi.org/10.3892/etm.2016.3178
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Abstract

The aim of the present study was to examine changes of cellular homeostasis in regulatory T (Treg) and T helper 17 (Th17) cells by detecting the proportion of Treg and Th17 cells of peripheral blood, as well as the expression of specific transcription factors in these two types of cells, in syphilitic patients with sero‑resistance. A total of 49 subjects were enrolled in the study and divided into two groups, comprising 26 cases of sero‑resistant syphilitic patients in the experimental group, and 23 cases of healthy donors in the normal control group. Flow cytometry was applied to examine the proportion of Treg and Th17 cells, as well as the quantitative expression of relevant specific transcription factors [forkhead box P3 (Foxp3) and retinoic acid-related orphan receptor γt (ROR‑γt)] in the two groups. A correlation analysis was subsequently performed. The results showed that in syphilitic patients with sero‑resistance, the proportion of peripheral blood Treg cells was obviously higher than that of the normal control group (p<0.01) and the proportion of Th17 cells was significantly lower than that of the normal control group (p<0.01). In addition, the expression of transcription factor Foxp3 in CD4+ T cells was higher than that of the normal control group, while the expression of ROR‑γt was lower than that of the normal control (p<0.05). The expression of Foxp3 and ROR‑γt in peripheral blood CD4+ T cells had a negative correlation (r=‑0.481, p<0.01). In conclusion, the peripheral blood of syphilitic patients with sero-resistance may have abnormalities in Treg/Th17 cellular balance.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Ma J, Zhang X, Li Q and Yang X: Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Exp Ther Med 11: 2300-2304, 2016.
APA
Zhao, J., Ma, J., Zhang, X., Li, Q., & Yang, X. (2016). Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Experimental and Therapeutic Medicine, 11, 2300-2304. https://doi.org/10.3892/etm.2016.3178
MLA
Zhao, J., Ma, J., Zhang, X., Li, Q., Yang, X."Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance". Experimental and Therapeutic Medicine 11.6 (2016): 2300-2304.
Chicago
Zhao, J., Ma, J., Zhang, X., Li, Q., Yang, X."Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2300-2304. https://doi.org/10.3892/etm.2016.3178
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Ma J, Zhang X, Li Q and Yang X: Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Exp Ther Med 11: 2300-2304, 2016.
APA
Zhao, J., Ma, J., Zhang, X., Li, Q., & Yang, X. (2016). Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Experimental and Therapeutic Medicine, 11, 2300-2304. https://doi.org/10.3892/etm.2016.3178
MLA
Zhao, J., Ma, J., Zhang, X., Li, Q., Yang, X."Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance". Experimental and Therapeutic Medicine 11.6 (2016): 2300-2304.
Chicago
Zhao, J., Ma, J., Zhang, X., Li, Q., Yang, X."Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2300-2304. https://doi.org/10.3892/etm.2016.3178
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