Basiliximab induction in kidney transplantation with donation after cardiac death donors

  • Authors:
    • Xuping Yao
    • Guobin Weng
    • Junjun Wei
    • Wenbo Gao
  • View Affiliations

  • Published online on: April 8, 2016     https://doi.org/10.3892/etm.2016.3238
  • Pages: 2541-2546
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Abstract

Basiliximab is a monoclonal antibody that binds to the α‑chain of the interleukin (IL)-2 receptor. It is used as induction therapy in kidney transplantation. The objective of the present study was to evaluate induction therapy with single-dose basiliximab (Simulect®) in kidney transplantation with donation after cardiac death (DCD) donors. A total of 33 DCD kidney transplants were performed between December 2010 and July 2013 in patients who received single‑dose basiliximab (20 mg) as induction therapy. The maintenance immunosuppression included calcineurin inhibitor (cyclosporine A or tacrolimus), mycophenolate mofetil and corticosteroids. The follow-up time was 1 year. The mean ages of the DCD donors and recipients were 29.3 and 41.1 years, respectively. Within the 1‑year follow‑up, the overall incidence of acute rejection was 9.1%. There were 10 cases of delayed graft function among the recipients. Mean serum creatinine values at 1 week and at 1, 3, 6, 9 and 12 months post‑transplantation were 257.6, 238.2, 194.5, 159.3, 137.9 and 110.8 µmol/l, respectively, with a favorable trend to allograft function recovery over time. The 1‑year patient and graft survival rates were 96.9 and 90.9%, respectively, with an infection rate of 24.2%. Increased alanine aminotransferase/aspartate transaminase levels in only 2 patients were considered to be associated with basiliximab. This experience with single‑dose basiliximab for induction therapy in DCD kidney transplantation showed that favorable clinical outcomes were achieved in terms of graft survival and function within 1 year.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yao X, Weng G, Wei J and Gao W: Basiliximab induction in kidney transplantation with donation after cardiac death donors. Exp Ther Med 11: 2541-2546, 2016
APA
Yao, X., Weng, G., Wei, J., & Gao, W. (2016). Basiliximab induction in kidney transplantation with donation after cardiac death donors. Experimental and Therapeutic Medicine, 11, 2541-2546. https://doi.org/10.3892/etm.2016.3238
MLA
Yao, X., Weng, G., Wei, J., Gao, W."Basiliximab induction in kidney transplantation with donation after cardiac death donors". Experimental and Therapeutic Medicine 11.6 (2016): 2541-2546.
Chicago
Yao, X., Weng, G., Wei, J., Gao, W."Basiliximab induction in kidney transplantation with donation after cardiac death donors". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2541-2546. https://doi.org/10.3892/etm.2016.3238