Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents

Zhou,Chenliang; Chen,Xiaobing; Wu,Liwen; Qu,Jing

doi:10.3892/etm.2016.3239

Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents

Authors:
- Chenliang Zhou
- Xiaobing Chen
- Liwen Wu
- Jing Qu
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Affiliations: Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, The People's Hospital in Altay Region, Altay, Xinjiang 836500, P.R. China
Published online on: April 8, 2016 https://doi.org/10.3892/etm.2016.3239
Pages: 2229-2232
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Open wound may lead to infection in patients. Due to overuse of medication, certain bacteria have become resistant to drugs currently available. The aim of the present study was to provide a guide to ameliorate the appropriate and rational use of clinical antimicrobial agents by analyzing the distribution of drug‑resistant pathogenic bacteria in patients. Between October 2013 and January 2015, 126 patients were selected at the Department of Orthopedics. Wound secretion samples were collected, and the pathogen bacteria isolated and identified. Identification was performed using an automated identification instrument and the Kirby‑Bauer antibiotic method was used to evaluate the bacterial resistance. Of the 126 patients, 118 patients were infected (infection rate, 93.65%). Additionally, 47 strains of gram‑positive pathogenic bacteria (39.83%) and 71 strains of pathogenic‑gram negative bacteria (60.17%) were identified. The bacteria were most likely to be resistant to penicillin while sensitive to vancomycin and imipenem. Some bacteria were resistant to several antibacterial agents. The results showed that existing risk factors at the Department of Orthopedics were complex and any non‑standard procedures were able to cause bacterial infection. There were obvious dissimilarities among infectious bacteria with regard to their sensitivity to various antibacterial agents. Manipulation techniques during the treatment process were performed in a sterile manner and the use of antibacterial agents was required to be strictly in accordance with the results of drug sensitivity tests to provide effective etiologic information and a treatment plan for clinical trials and to reduce the risk of infection by multi‑resistant bacteria.

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