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Article Open Access

Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents

  • Authors:
    • Chenliang Zhou
    • Xiaobing Chen
    • Liwen Wu
    • Jing Qu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, The People's Hospital in Altay Region, Altay, Xinjiang 836500, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2229-2232
    |
    Published online on: April 8, 2016
       https://doi.org/10.3892/etm.2016.3239
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Abstract

Open wound may lead to infection in patients. Due to overuse of medication, certain bacteria have become resistant to drugs currently available. The aim of the present study was to provide a guide to ameliorate the appropriate and rational use of clinical antimicrobial agents by analyzing the distribution of drug‑resistant pathogenic bacteria in patients. Between October 2013 and January 2015, 126 patients were selected at the Department of Orthopedics. Wound secretion samples were collected, and the pathogen bacteria isolated and identified. Identification was performed using an automated identification instrument and the Kirby‑Bauer antibiotic method was used to evaluate the bacterial resistance. Of the 126 patients, 118 patients were infected (infection rate, 93.65%). Additionally, 47 strains of gram‑positive pathogenic bacteria (39.83%) and 71 strains of pathogenic‑gram negative bacteria (60.17%) were identified. The bacteria were most likely to be resistant to penicillin while sensitive to vancomycin and imipenem. Some bacteria were resistant to several antibacterial agents. The results showed that existing risk factors at the Department of Orthopedics were complex and any non‑standard procedures were able to cause bacterial infection. There were obvious dissimilarities among infectious bacteria with regard to their sensitivity to various antibacterial agents. Manipulation techniques during the treatment process were performed in a sterile manner and the use of antibacterial agents was required to be strictly in accordance with the results of drug sensitivity tests to provide effective etiologic information and a treatment plan for clinical trials and to reduce the risk of infection by multi‑resistant bacteria.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou C, Chen X, Wu L and Qu J: Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents. Exp Ther Med 11: 2229-2232, 2016.
APA
Zhou, C., Chen, X., Wu, L., & Qu, J. (2016). Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents. Experimental and Therapeutic Medicine, 11, 2229-2232. https://doi.org/10.3892/etm.2016.3239
MLA
Zhou, C., Chen, X., Wu, L., Qu, J."Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents". Experimental and Therapeutic Medicine 11.6 (2016): 2229-2232.
Chicago
Zhou, C., Chen, X., Wu, L., Qu, J."Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2229-2232. https://doi.org/10.3892/etm.2016.3239
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Chen X, Wu L and Qu J: Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents. Exp Ther Med 11: 2229-2232, 2016.
APA
Zhou, C., Chen, X., Wu, L., & Qu, J. (2016). Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents. Experimental and Therapeutic Medicine, 11, 2229-2232. https://doi.org/10.3892/etm.2016.3239
MLA
Zhou, C., Chen, X., Wu, L., Qu, J."Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents". Experimental and Therapeutic Medicine 11.6 (2016): 2229-2232.
Chicago
Zhou, C., Chen, X., Wu, L., Qu, J."Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2229-2232. https://doi.org/10.3892/etm.2016.3239
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