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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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July-2016 Volume 12 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis

  • Authors:
    • Hai‑Peng Zhu
    • Yu‑Rong Gu
    • Geng‑Lin Zhang
    • Yu‑Jie Su
    • Ke Wang
    • Yu‑Bao Zheng
    • Zhi‑Liang Gao
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Dongguan People's Hospital, Dongguan, Guangdong 523059, P.R. China, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China
  • Pages: 405-409
    |
    Published online on: April 20, 2016
       https://doi.org/10.3892/etm.2016.3271
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Abstract

Depression in patients with chronic hepatitis B (CHB) can affect the quality of life, disease diagnosis and case fatality rate. The aim of this study was to explore depression in patients with CHB and cirrhosis, and the effect of the severity of liver cirrhosis on the depressive emotional state. The depressive emotional state was investigated using the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in 114 patients with CHB and cirrhosis, comprising 42 cases classified as Child‑Pugh grade (CPG)‑A, 38 cases classified as CPG‑B and 34 cases classified as CPG‑C at a single hepatology center. Patients with mood disorders accounted for 33.33% of the 114 cases with CHB and liver cirrhosis and comprised 10 cases of CPG‑A, 12 cases of CPG‑B and 16 cases of CPG‑C classification. The results shows that HAMA and HAMD scores of patients in the CPG‑C group were significantly higher than those in the CPG‑A group (P<0.01), but not significantly higher than those in the CPG‑B group (P>0.05). The incidence rate of mood disorders in the CPG‑C group was significantly higher than that in the CPG‑B group (P=0.0336), and the incidence rate of mood disorders was higher in the CPG‑B group compared with the CPG‑A group, but the difference was not statistically significant (P=0.4370). The incidence rate of mood disorders in patients in the CPG‑A group was significantly lower than that in the CPG‑C group (P=0.0078). The study shows that a considerable proportion of patients with liver cirrhosis have mood disorders, and the depression rates of CHB‑infected patients with liver cirrhosis are closely associated with the severity of the cirrhosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu HP, Gu YR, Zhang GL, Su YJ, Wang K, Zheng YB and Gao ZL: Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis. Exp Ther Med 12: 405-409, 2016.
APA
Zhu, H., Gu, Y., Zhang, G., Su, Y., Wang, K., Zheng, Y., & Gao, Z. (2016). Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis. Experimental and Therapeutic Medicine, 12, 405-409. https://doi.org/10.3892/etm.2016.3271
MLA
Zhu, H., Gu, Y., Zhang, G., Su, Y., Wang, K., Zheng, Y., Gao, Z."Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis". Experimental and Therapeutic Medicine 12.1 (2016): 405-409.
Chicago
Zhu, H., Gu, Y., Zhang, G., Su, Y., Wang, K., Zheng, Y., Gao, Z."Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis". Experimental and Therapeutic Medicine 12, no. 1 (2016): 405-409. https://doi.org/10.3892/etm.2016.3271
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu HP, Gu YR, Zhang GL, Su YJ, Wang K, Zheng YB and Gao ZL: Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis. Exp Ther Med 12: 405-409, 2016.
APA
Zhu, H., Gu, Y., Zhang, G., Su, Y., Wang, K., Zheng, Y., & Gao, Z. (2016). Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis. Experimental and Therapeutic Medicine, 12, 405-409. https://doi.org/10.3892/etm.2016.3271
MLA
Zhu, H., Gu, Y., Zhang, G., Su, Y., Wang, K., Zheng, Y., Gao, Z."Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis". Experimental and Therapeutic Medicine 12.1 (2016): 405-409.
Chicago
Zhu, H., Gu, Y., Zhang, G., Su, Y., Wang, K., Zheng, Y., Gao, Z."Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis". Experimental and Therapeutic Medicine 12, no. 1 (2016): 405-409. https://doi.org/10.3892/etm.2016.3271
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