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Article

Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma

  • Authors:
    • Luchen Xue
    • Zhiwen Xu
    • Kunhao Wang
    • Ning Wang
    • Xiaoxu Zhang
    • Shang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Software Engineering, Jilin University, Changchun, Jilin 130012, P.R. China, Key Laboratory of Symbol Computation and Knowledge Engineering of the Ministry of Education, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 437-444
    |
    Published online on: April 20, 2016
       https://doi.org/10.3892/etm.2016.3272
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Abstract

Numerous studies have investigated the roles played by various genes and microRNAs (miRNAs) in neoplasms, including anaplastic astrocytoma (AA). However, the specific regulatory mechanisms involving these genes and miRNAs remain unclear. In the present study, associated biological factors (miRNAs, transcription factors, target genes and host genes) from existing studies of human AA were combined methodically through the interactions between genes and miRNAs, as opposed to studying one or several. Three regulatory networks, including abnormally expressed, related and global networks were constructed with the aim of identifying significant gene and miRNA pathways. Each network is composed of three associations between miRNAs targeted at genes, transcription factors (TFs) regulating miRNAs and miRNAs located on their host genes. Among these, the abnormally expressed network, which involves the pathways of previously identified abnormally expressed genes and miRNAs, partially indicated the regulatory mechanism underlying AA. The network contains numerous abnormal regulation associations when AA emerges. By modifying the abnormally expressed network factors to a normal expression pattern, the faulty regulation may be corrected and tumorigenesis of AA may be prevented. Certain specific pathways are highlighted in AA, for example PTEN which is targeted by miR‑21 and miR‑106b, regulates miR‑25 which in turn targets TP53. PTEN and miR‑21 have been observed to form feedback loops. Furthermore, by comparing and analyzing the pathway predecessors and successors of abnormally expressed genes and miRNAs in three networks, similarities and differences of regulatory pathways may be identified and proposed. In summary, the present study aids in elucidating the occurrence, mechanism, prevention and treatment of AA. These results may aid further investigation into therapeutic approaches for this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Xue L, Xu Z, Wang K, Wang N, Zhang X and Wang S: Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma. Exp Ther Med 12: 437-444, 2016.
APA
Xue, L., Xu, Z., Wang, K., Wang, N., Zhang, X., & Wang, S. (2016). Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma. Experimental and Therapeutic Medicine, 12, 437-444. https://doi.org/10.3892/etm.2016.3272
MLA
Xue, L., Xu, Z., Wang, K., Wang, N., Zhang, X., Wang, S."Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma". Experimental and Therapeutic Medicine 12.1 (2016): 437-444.
Chicago
Xue, L., Xu, Z., Wang, K., Wang, N., Zhang, X., Wang, S."Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma". Experimental and Therapeutic Medicine 12, no. 1 (2016): 437-444. https://doi.org/10.3892/etm.2016.3272
Copy and paste a formatted citation
x
Spandidos Publications style
Xue L, Xu Z, Wang K, Wang N, Zhang X and Wang S: Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma. Exp Ther Med 12: 437-444, 2016.
APA
Xue, L., Xu, Z., Wang, K., Wang, N., Zhang, X., & Wang, S. (2016). Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma. Experimental and Therapeutic Medicine, 12, 437-444. https://doi.org/10.3892/etm.2016.3272
MLA
Xue, L., Xu, Z., Wang, K., Wang, N., Zhang, X., Wang, S."Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma". Experimental and Therapeutic Medicine 12.1 (2016): 437-444.
Chicago
Xue, L., Xu, Z., Wang, K., Wang, N., Zhang, X., Wang, S."Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma". Experimental and Therapeutic Medicine 12, no. 1 (2016): 437-444. https://doi.org/10.3892/etm.2016.3272
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