Open Access

Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review

  • Authors:
    • Jun Zhang
    • Heng‑Yuan Zhang
    • Shi‑Zhi Chen
    • Ji‑Yi Huang
  • View Affiliations

  • Published online on: May 17, 2016     https://doi.org/10.3892/etm.2016.3349
  • Pages: 1012-1018
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cholesterol embolism is a multisystemic disorder with clinical manifestations that resemble vasculitis. Anti‑neutrophil cytoplasmic antibodies (ANCA) are a defining feature of ANCA‑associated vasculitis, and the presence of ANCA in cholesterol embolism complicates its differential diagnosis and treatment. At present, the role of ANCA in cholesterol embolism remains unclear and no effective treatment is currently available. The present study reports the case of an Asian male who presented with spontaneous cholesterol embolism with proteinase 3 (PR3)‑specific ANCA, subacute interstitial nephritis and late‑developing skin lesions. The 69‑year‑old patient was admitted to The First Affiliated Hospital of Xiamen University (Xiamen, China) complaining of chest tightness, fatigue, progressive renal failure and refractory hypertension. In addition, transient eosinophilia was detected. Following immunosuppressive therapy with steroids and cyclophosphamide for 6 months, hemodialysis treatment was initiated. Skin lesions appeared at >1 month following hemodialysis initiation; however, they were gradually improved following treatment with atorvastatin and anti‑platelet aggregation therapy for 5 months. The patient was maintained on hemodialysis for ~2 years and exhibited general good health at the most recent follow‑up. In addition, 11 cases of cholesterol embolism associated with ANCA reported in the literature were discussed in the present study.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang J, Zhang HY, Chen SZ and Huang JY: Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review. Exp Ther Med 12: 1012-1018, 2016
APA
Zhang, J., Zhang, H., Chen, S., & Huang, J. (2016). Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review. Experimental and Therapeutic Medicine, 12, 1012-1018. https://doi.org/10.3892/etm.2016.3349
MLA
Zhang, J., Zhang, H., Chen, S., Huang, J."Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review". Experimental and Therapeutic Medicine 12.2 (2016): 1012-1018.
Chicago
Zhang, J., Zhang, H., Chen, S., Huang, J."Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1012-1018. https://doi.org/10.3892/etm.2016.3349