Diagnosis and stage of Graves' ophthalmopathy: Efficacy of quantitative measurements of the lacrimal gland based on 3-T magnetic resonance imaging

Hu,Hao; Xu,Xiao‑Quan; Wu,Fei‑Yun; Chen,Huan‑Huan; Su,Guo‑Yi; Shen,Jie; Hong,Xun‑Ning; Shi,Hai‑Bin

doi:10.3892/etm.2016.3389

August-2016 Volume 12 Issue 2

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August-2016 Volume 12 Issue 2

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Diagnosis and stage of Graves' ophthalmopathy: Efficacy of quantitative measurements of the lacrimal gland based on 3-T magnetic resonance imaging

Authors:
- Hao Hu
- Xiao‑Quan Xu
- Fei‑Yun Wu
- Huan‑Huan Chen
- Guo‑Yi Su
- Jie Shen
- Xun‑Ning Hong
- Hai‑Bin Shi
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Affiliations: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China

Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 725-729
|
Published online on: May 25, 2016

https://doi.org/10.3892/etm.2016.3389
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Abstract

The aim of the present study was to determine the efficacy of quantitative measurements of the lacrimal gland based on 3-T magnetic resonance (MR) imaging in the diagnosis and staging of Graves' ophthalmopathy (GO). The study retrospectively enrolled 33 patients with GO (the GO group) and 24 healthy volunteers [the healthy control (HC) group] with orbit MR imaging performed using a 3‑T MR scanner. Quantitative parameters of the lacrimal gland, including axial length, axial width, axial area, coronal length, coronal width, coronal area, volume and signal intensity ratio (SIR) of the lacrimal gland to the ipsilateral temporal muscle were measured. The difference of quantitative parameters between the GO and HC groups, or between active and inactive GO groups were evaluated using a Student's t-test. Receiver operating characteristic analyses were used to evaluate the diagnostic value of the significant parameters in discriminating patients with GO from healthy controls, or discriminating active from inactive GO. All the quantitative measurements of the GO patients were significantly larger than those of the healthy controls (P<0.05), with the exception of the coronal length (P=0.150). Axial and coronal width had the best efficacy in discriminating patients with GO from healthy controls. Only SIR was found to be different between the active and inactive GO groups (P=0.001). Setting a SIR of 2.57 as the threshold value, the optimal efficacy was achieved (area under the curve, 0.711; sensitivity, 57.7%; specificity, 77.5%) in discriminating between active and inactive GO. Quantitative measurements of the lacrimal gland based on 3‑T MR imaging may assist in the diagnosis and stage of GO.

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1	Iyer S and Bahn R: Immunopathogenesis of Graves' ophthalmopathy: The role of the TSH receptor. Best Pract Res Clin Endocrinol Metab. 26:281–289. 2012. View Article : Google Scholar : PubMed/NCBI
2	Ludgate M and Baker G: Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease. Clin Exp Immunol. 127:193–198. 2002. View Article : Google Scholar : PubMed/NCBI
3	Gilbard JP and Farris RL: Ocular surface drying and tear film osmolarity in thyroid eye disease. Acta Ophthalmol (Copenh). 61:108–116. 1983. View Article : Google Scholar : PubMed/NCBI
4	Khurana AK, Sunder S, Ahluwalia BK and Malhotra KC: Tear film profile in Graves' ophthalmopathy. Acta Ophthalmol (Copenh). 70:346–349. 1992. View Article : Google Scholar : PubMed/NCBI
5	Chang TC, Huang KM, Chang TJ and Lin SL: Correlation of orbital computed tomography and antibodies in patients with hyperthyroid Graves' disease. Clin Endocrinol (Oxf). 32:551–558. 1990. View Article : Google Scholar : PubMed/NCBI
6	Eckstein AK, Finkenrath A, Heiligenhaus A, Renzing-Köhler K, Esser J, Krüger C, Quadbeck B, Steuhl KP and Gieseler RK: Dry eye syndrome in thyroid-associated ophthalmopathy: Lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. Acta Ophthalmol Scand. 82:291–297. 2004. View Article : Google Scholar : PubMed/NCBI
7	Jacobson DH and Gorman CA: Endocrine ophthalmopathy: Current ideas concerning etiology, pathogenesis and treatment. Endocr Rev. 5:200–220. 1984. View Article : Google Scholar : PubMed/NCBI
8	Harris MA, Realini T, Hogg JP and Sivak-Callcott JA: CT dimensions of the lacrimal gland in Graves orbitopathy. Ophthal Plast Reconstr Surg. 28:69–72. 2012. View Article : Google Scholar : PubMed/NCBI
9	Bingham CM, Harris MA, Realini T, Nguyen J, Hogg JP and Sivak-Callcott JA: Calculated computed tomography volumes of lacrimal glands and comparison to clinical findings in patients with thyroid eye disease. Ophthal Plast Reconstr Surg. 30:116–118. 2014. View Article : Google Scholar : PubMed/NCBI
10	Bhatti MT and Dutton JJ: Thyroid eye disease: Therapy in the active phase. J Neuroophthalmol. 34:186–197. 2014. View Article : Google Scholar : PubMed/NCBI
11	Bartalena L, Pinchera A and Marcocci C: Management of Graves' ophthalmopathy: Reality and perspectives. Endocr Rev. 21:168–199. 2000. View Article : Google Scholar : PubMed/NCBI
12	Tortora F, Prudente M, Cirillo M, Elefante A, Belfiore MP, Romano F, Cappabianca S, Carella C and Cirillo S: Diagnostic accuracy of short-time inversion recovery sequence in Graves' ophthalmopathy before and after prednisone treatment. Neuroradiology. 56:353–361. 2014. View Article : Google Scholar : PubMed/NCBI
13	European Group on Graves' Orbitopathy (EUGOGO). Wiersinga WM, Perros P, Kahaly GJ, Mourits MP, Baldeschi L, Boboridis K, Boschi A, Dickinson AJ, Kendall-Taylor P, Krassas GE, et al: Clinical assessment of patients with Graves' orbitopathy: The European Group on Graves' orbitopathy recommendations to generalists, specialists and clinical researchers. Eur J Endocrinol. 155:387–389. 2006. View Article : Google Scholar : PubMed/NCBI
14	Mourits MP, Prummel MF, Wiersinga WM and Koornneef L: Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy. Clin Endocrinol (Oxf). 47:9–14. 1997. View Article : Google Scholar : PubMed/NCBI
15	Tamboli DA, Harris MA, Hogg JP, Realini T and Sivak-Callcott JA: Computed tomography dimensions of the lacrimal gland in normal caucasian orbits. Ophthal Plast Reconstr Surg. 27:453–456. 2011. View Article : Google Scholar : PubMed/NCBI
16	Huang D, Luo Q, Yang H and Mao Y: Changes of lacrimal gland and tear inflammatory cytokines in thyroid-associated ophthalmopathy. Invest Ophthalmol Vis Sci. 55:4935–4943. 2014. View Article : Google Scholar : PubMed/NCBI
17	Mayer EJ, Fox DL, Herdman G, Hsuan J, Kabala J, Goddard P, Potts MJ and Lee RW: Signal intensity, clinical activity and cross-sectional areas on MRI scans in thyroid eye disease. Eur J Radiol. 56:20–24. 2005. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diagnosis and stage of Graves' ophthalmopathy: Efficacy of quantitative measurements of the lacrimal gland based on 3-T magnetic resonance imaging

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