Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors

  • Authors:
    • Zhao Ma
    • Xuebin Bao
    • Junbao Gu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China
  • Pages: 983-986
    |
    Published online on: May 27, 2016
       https://doi.org/10.3892/etm.2016.3404
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The effects of laparoscopic radical gastrectomy were observed, and changes in immune function and inflammatory factors of gastric cancer patients were examined. In total, 236 cases of laparoscopic radical gastrectomy were selected between March 2014 and October 2015 and divided into the control and experimental groups. The control group was treated using open radical gastrectomy, while laparoscopic radical gastrectomy was used in the experimental group. Treatment effects, immune function and inflammatory factor in the two groups were compared. Compared to the open radical gastrectomy group, surgery time in the laparoscopic radical gastrectomy group was longer, while blood loss during operation, time of exsufflation through anus after operation, duration of acesodyne use, length of stay and incidence of complications were lower, and the differences were statistically significant (P<0.05). As for the amount of lymph node dissection, differences between the two groups were of no statistical significance (P>0.05). CD3+, CD4+ and CD4+/CD8+ cell ratios in the two groups 1 and 7 days after surgery were obviously lower than those before surgery (P<0.05) while CD8+ was higher. In addition, compared with the open radical gastrectomy group, CD3+, CD4+, CD4+/CD8+ cell ratios in the laparoscopic radical gastrectomy group increased while CD8 was lower, and differences were statistically significant (P<0.05). Differences of interleukin (IL)-6, tumor necrosis factor (TNF) and CRP between the two groups 1 day before surgery were of no statistical significance (P>0.05). One day after surgery, IL-6, TNF and CRP in the two groups increased (P<0.05) and the values in the open radical gastrectomy group were higher (P<0.05). Differences in IL-6 between the two groups 7 days after surgery were of no statistical significance (P>0.05). However, for CRP and TNF, the two values gradually decreased and the differences between the groups were of statistical significance (P<0.05). In conclusion, laparoscopic radical gastrectomy has better treatment effects, lower inflammatory response, less impact on the immune system and fewer complications, which is worth clinical consideration.
View Figures
View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Shin A, Kim J and Park S: Gastric cancer epidemiology in Korea. J Gastric Cancer. 11:135–140. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Bilici A, Selcukbiricik F, Demir N, Oven Ustaalioglu BB, Dikilitas M and Yildiz O: Modified docetaxel and cisplatin in combination with capecitabine (DCX) as a first-line treatment in HER2- negative advanced gastric cancer. Asian Pac J Cancer Prev. 15:8661–8666. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Liu J, Qu XJ, Xu L, Zang Y, Qu JL, Hou KZ and Liu YP: Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells. Dig Dis Sci. 55:3361–3368. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Smyth EC and Cunningham D: Targeted therapy for gastric cancer. Current treatment options in oncology. 13:377–389. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wong H and Yau T: Molecular targeted therapies in advanced gastric cancer: does tumor histology matter? Therap Adv Gastroenterol. 6:15–31. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Nadauld LD and Ford JM: Molecular profiling of gastric cancer: toward personalized cancer medicine. J Clin Oncol. 31:838–839. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Huang CM, Lin JX, Zheng CH, Li P, Xie JW, Wang JB, Lu J and Chen QY: Clinical efficacy analysis of laparoscopy-assisted radical gastrectomy for 1380 patients with gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi. 15:1265–1268. 2012.(In Chinese). PubMed/NCBI

9 

Yoshimura F, Inaba K, Kawamura Y, Ishida Y, Taniguchi K, Isogaki J, Satoh S, Kanaya S, Sakurai Y and Uyama I: Clinical outcome and clinicopathological characteristics of recurrence after laparoscopic gastrectomy for advanced gastric cancer. Digestion. 83:184–190. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wang DR, Zhao JG, Yu HF, Wang LH, Jiang GQ, Li YK and Chen J: Laparoscopic versus open surgery for D2 gastrectomy in advanced gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi. 15:964–966. 2012.(In Chinese). PubMed/NCBI

11 

Huang Z, Li G, Xu Y, Wang G and You S: Comparison of laparoscope-assisted D2 radical total gastrectomy and open gastrectomy for gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi. 17:781–784. 2014.(In Chinese). PubMed/NCBI

12 

Gong J, Cao Y, Wang Y, Zhang G, Wang P and Luo G: Three-step hand-assisted laparoscopic d2 radical gastrectomy for Chinese obese patients: A highly efficient and feasible surgical approach. J Cancer. 6:120–127. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Liu R, Zhang Z, Xue Q, Yan J, Yu J, Liu H, Zhao L, Mou T, Deng H, et al: A safety study of transumbilical single incision versus conventional laparoscopic surgery for colorectal cancer: study protocol for a randomized controlled trial. Trials. 16:5392015. View Article : Google Scholar : PubMed/NCBI

14 

Cui M, Gong C, Jiang B, Yao Z, Chen L, Di J, Xing J, Yang H, Zhang C, Zhang N, et al: Evaluation of immune responses of gastric cancer patients treated by laparoscopic and open gastrectomy. Med Oncol. 32:2532015. View Article : Google Scholar : PubMed/NCBI

15 

Hu Y, Zhao G and Zheng H: Therapeutic effects of laparotomy and laparoscopic surgery on patients with gastric cancer. Pak J Med Sci. 31:572–575. 2015.PubMed/NCBI

16 

Zhao HQ, Liu HR, Xiao L, Zheng F and Li WM: Laparoscopic cholecystectomy in elderly patients: an evaluation of immunity. Aging Clin Exp Res. 27:927–933. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Chang TC, Chen CC, Wang MY, Yang CY and Lin MT: Gasless laparoscopy-assisted distal gastrectomy for early gastric cancer: analysis of initial results. J Laparoendosc Adv Surg Tech A. 21:215–220. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Louis-Dit-Sully C, Blumenthal B, Duchniewicz M, Beck-Garcia K, Fiala GJ, Beck-García E, Mukenhirn M, Minguet S and Schamel WW: Activation of the TCR complex by peptide-MHC and superantigens. EXS. 104:9–23. 2014.PubMed/NCBI

19 

Larsen SK: Cellular immune responses towards regulatory cells. Dan Med J. 63:pii: B5188. 2016.

20 

Brentville VA, Metheringham RL, Gunn B, Symonds P, Daniels I, Gijon M, Cook K, Xue W and Durrant LG: Citrullinated vimentin presented on MHC-II in tumor cells is a target for CD4 T cell-mediated antitumor immunity. Cancer Res. 76:548–560. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Jackutė J, Žemaitis M, Pranys D, Šitkauskienė B, Miliauskas S, Bajoriūnas V and Sakalauskas R: Distribution of CD4(+) and CD8(+) T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking. Medicina (Kaunas). 51:263–271. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Jackute J, Zemaitis M, Pranys D, Sitkauskiene B, Miliauskas S, Bajoriunas V, Lavinskiene S and Sakalauskas R: The prognostic influence of tumor infiltrating Foxp3(+)CD4(+), CD4(+) and CD8(+) T cells in resected non-small cell lung cancer. J Inflamm (Lond). 12:632015. View Article : Google Scholar : PubMed/NCBI

23 

Chen M, Mohtize M, Matteï MF, Villemot JP, Kohler C, Faure GC, Béné MC and de Carvalho Bittencourt M: Reduced levels of both circulating CD4+ CD25+ CD127(low/neg) and CD4+ CD8(neg) invariant natural killer regulatory T cells in stable heart transplant recipients. Clin Exp Immunol. 163:104–112. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma Z, Bao X and Gu J: Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors. Exp Ther Med 12: 983-986, 2016.
APA
Ma, Z., Bao, X., & Gu, J. (2016). Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors. Experimental and Therapeutic Medicine, 12, 983-986. https://doi.org/10.3892/etm.2016.3404
MLA
Ma, Z., Bao, X., Gu, J."Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors". Experimental and Therapeutic Medicine 12.2 (2016): 983-986.
Chicago
Ma, Z., Bao, X., Gu, J."Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors". Experimental and Therapeutic Medicine 12, no. 2 (2016): 983-986. https://doi.org/10.3892/etm.2016.3404
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Z, Bao X and Gu J: Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors. Exp Ther Med 12: 983-986, 2016.
APA
Ma, Z., Bao, X., & Gu, J. (2016). Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors. Experimental and Therapeutic Medicine, 12, 983-986. https://doi.org/10.3892/etm.2016.3404
MLA
Ma, Z., Bao, X., Gu, J."Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors". Experimental and Therapeutic Medicine 12.2 (2016): 983-986.
Chicago
Ma, Z., Bao, X., Gu, J."Effects of laparoscopic radical gastrectomy and the influence on immune function and inflammatory factors". Experimental and Therapeutic Medicine 12, no. 2 (2016): 983-986. https://doi.org/10.3892/etm.2016.3404
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team