Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1

  • Authors:
    • Guizuo Wang
    • Yang Song
    • Wei Feng
    • Lu Liu
    • Yanting Zhu
    • Xinming Xie
    • Yilin Pan
    • Rui Ke
    • Shaojun Li
    • Fangwei Li
    • Lan Yang
    • Manxiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Internal Medicine, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shanxi 710061, P.R. China
  • Pages: 1551-1555
    |
    Published online on: June 17, 2016
       https://doi.org/10.3892/etm.2016.3465
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Evidence suggests that an imbalance between oxidation and antioxidation is involved in the pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Activation of AMP-activated protein kinase (AMPK) has been shown to inhibit the occurrence of ALI/ARDS. However, it is unknown whether activation of AMPK benefits ALI/ARDS by restoration of the oxidant and antioxidant balance, and which mechanisms are responsible for this process. The present study aimed to address these issues. Lipopolysaccharide (LPS) induced pronounced pathological changes of ALI in mice; these were accompanied by elevated production of malondialdehyde (MDA) and decreased activity of superoxide dismutase (SOD) compared with control mice. Prior treatment of mice with the AMPK agonist metformin significantly suppressed the LPS‑induced development of ALI, reduced the elevation of MDA and increased the activity of SOD. Further analysis indicated that activation of AMPK also stimulated the protein expression of peroxisome proliferator‑activated receptor γ coactivator 1α (PGC1α) and superoxide dismutase 1 (SOD1). This study suggests that activation of AMPK by metformin inhibits oxidative stress by upregulation of PGC1α and SOD1, thereby suppressing the development of ALI/ARDS, and has potential value in the clinical treatment of such conditions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Walkey AJ, Summer R, Ho V and Alkana P: Acute respiratory distress syndrome: Epidemiology and management approaches. Clin Epidemiol. 4:159–169. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Rosanna DP and Salvatore C: Reactive oxygen species, inflammation and lung diseases. Curr Pharm Des. 18:3889–3900. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Park HS, Kim SR and Lee YC: Impact of oxidative stress on lung diseases. Respirology. 14:27–38. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Crimi E, Sica V, Williams-Ignarro S, Zhang H, Slutsky AS, Ignarro LJ and Napoli C: The role of oxidative stress in adult critical care. Free Radic Biol Med. 40:398–406. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA and Day BJ: Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 31:2309–2315. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Xu JN, Zeng C, Zhou Y, Peng C, Zhou YF and Xue Q: Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation. J Clin Endocrinol Metab. 99:2795–2803. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Jeong HW, Hsu KC, Lee JW, Ham M, Huh JY, Shin HJ, Kim WS and Kim JB: Berberine suppresses proinflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol Metab. 296:E955–E964. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Han Y, Jiang C, Tang J, Wang C, Wu P, Zhang G, Liu W, Jamangulova N, Wu X and Song X: Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain. 18:1458–1470. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Yee SW, Chen L and Giacomini KM: The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 44:359–360. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Su RY, Chao Y, Chen TY, Huang DY and Lin WW: 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. Mol Cancer Ther. 6:1562–1571. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Zhao X, Zmijewski JW, Lorne E, Liu G, Park YJ, Tsuruta Y and Abraham E: Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 295:L497–L504. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Wang G, Liu L, Zhang Y, Han D, Liu J, Xu J, Xie X, Wu Y, Zhang D, Ke R, et al: Activation of PPARγ attenuates LPS-induced acute lung injury by inhibition of HMGB1-RAGE levels. Eur J Pharmacol. 726:27–32. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Fukai T and Ushio-Fukai M: Superoxide dismutases: Role in redox signaling, vascular function and diseases. Antioxid Redox Signal. 15:1583–1606. 2011. View Article : Google Scholar : PubMed/NCBI

14 

St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, et al: Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 127:397–408. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Tasaka S, Amaya F, Hashimoto S and Ishizaka A: Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome. Antioxid Redox Signal. 10:739–753. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Kim MY, Lim JH, Youn HH, Hong YA, Yang KS, Park HS, Chung S, Ko SH, Shin SJ, Choi BS, et al: Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1 α axis in db/db mice. Diabetologia. 56:204–217. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Tamaki N, Cristina Orihuela-Campos R, Inagaki Y, Fukui M, Nagata T and Ito HO: Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model. Free Radic Biol Med. 75:222–229. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Marmolino D, Manto M, Acquaviva F, Vergara P, Ravella A, Monticelli A and Pandolfo M: PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. PLoS One. 5:e100252010. View Article : Google Scholar : PubMed/NCBI

19 

Liu C and Lin JD: PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai). 43:248–257. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Valle I, Alvarez-Barrientos A, Arza E, Lamas S and Monsalve M: PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res. 66:562–573. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E and La Spada AR: PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci Transl Med. 4:142ra972012. View Article : Google Scholar : PubMed/NCBI

22 

Liu SC, Tu YK, Chien MN and Chien KL: Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: A network meta-analysis. Diabetes Obes Metab. 14:810–820. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang G, Song Y, Feng W, Liu L, Zhu Y, Xie X, Pan Y, Ke R, Li S, Li F, Li F, et al: Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1. Exp Ther Med 12: 1551-1555, 2016.
APA
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X. ... Li, M. (2016). Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1. Experimental and Therapeutic Medicine, 12, 1551-1555. https://doi.org/10.3892/etm.2016.3465
MLA
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X., Pan, Y., Ke, R., Li, S., Li, F., Yang, L., Li, M."Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1". Experimental and Therapeutic Medicine 12.3 (2016): 1551-1555.
Chicago
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X., Pan, Y., Ke, R., Li, S., Li, F., Yang, L., Li, M."Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1551-1555. https://doi.org/10.3892/etm.2016.3465
Copy and paste a formatted citation
x
Spandidos Publications style
Wang G, Song Y, Feng W, Liu L, Zhu Y, Xie X, Pan Y, Ke R, Li S, Li F, Li F, et al: Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1. Exp Ther Med 12: 1551-1555, 2016.
APA
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X. ... Li, M. (2016). Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1. Experimental and Therapeutic Medicine, 12, 1551-1555. https://doi.org/10.3892/etm.2016.3465
MLA
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X., Pan, Y., Ke, R., Li, S., Li, F., Yang, L., Li, M."Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1". Experimental and Therapeutic Medicine 12.3 (2016): 1551-1555.
Chicago
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X., Pan, Y., Ke, R., Li, S., Li, F., Yang, L., Li, M."Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1551-1555. https://doi.org/10.3892/etm.2016.3465
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team