Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats

  • Authors:
    • Su Jin Kang
    • Eun Kyung Lee
    • Chang Hyun Han
    • Bong Hyo Lee
    • Young Joon Lee
    • Sae Kwang Ku
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  • Published online on: July 4, 2016     https://doi.org/10.3892/etm.2016.3499
  • Pages: 1563-1571
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Abstract

Persicariae Rhizoma (PR) is the dried stem parts of Persicaria tinctoria H. Gross (Polygonaceae), and has been traditionally used as anti‑inflammatory and detoxifying agent. In the present study, the effects of PR aqueous extracts on ligation‑induced experimental periodontitis (EPD) and associated alveolar bone loss in rats were examined. Following the induction of EPD in rats, PR extracts were orally administered once a day for 10 days, and the changes and gains in body weight, alveolar bone loss and total aerobic bacterial counts of buccal gingiva were observed with histopathological analysis. In addition, anti‑inflammatory effects were evaluated by monitoring myeloperoxidase (MPO) activities, and interleukin (IL)‑1β and tumor necrosis factor (TNF)‑α contents, and anti-oxidant effects were investigated by measuring inducible nitric oxide synthase (iNOS) activities and malondialdehyde (MDA) levels. Bacterial proliferation, periodontitis and associated alveolar bone loss induced by ligature placement were significantly and dose‑dependently inhibited by the treatment with PR extracts. The inhibitory effects of 200 mg/kg PR were similar to those of 5 mg/kg indomethacin on ligation‑induced periodontitis and associated alveolar bone losses in this study. The results suggest that PR effectively inhibits ligature placement‑induced periodontitis and alveolar bone loss in rats via antibacterial, antioxidative and anti-inflammatory activities.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kang SJ, Lee EK, Han CH, Lee BH, Lee YJ and Ku SK: Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats. Exp Ther Med 12: 1563-1571, 2016
APA
Kang, S.J., Lee, E.K., Han, C.H., Lee, B.H., Lee, Y.J., & Ku, S.K. (2016). Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats. Experimental and Therapeutic Medicine, 12, 1563-1571. https://doi.org/10.3892/etm.2016.3499
MLA
Kang, S. J., Lee, E. K., Han, C. H., Lee, B. H., Lee, Y. J., Ku, S. K."Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats". Experimental and Therapeutic Medicine 12.3 (2016): 1563-1571.
Chicago
Kang, S. J., Lee, E. K., Han, C. H., Lee, B. H., Lee, Y. J., Ku, S. K."Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1563-1571. https://doi.org/10.3892/etm.2016.3499