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Article

Inhibitory effect of α-solanine on esophageal carcinoma in vitro

  • Authors:
    • Lei Wang
    • Qian‑Qian Sun
    • Shi‑Jie Zhang
    • Yu‑Wen Du
    • Yuan‑Yuan Wang
    • Wen‑Qiao Zang
    • Xiao‑Nan Chen
    • Guo‑Qiang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 1525-1530
    |
    Published online on: July 4, 2016
       https://doi.org/10.3892/etm.2016.3500
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Abstract

α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in potatoes, has been observed to inhibit growth and induce apoptosis in cancer cells. However, the antitumor efficacy of α‑solanine on esophageal carcinoma has yet to be fully elucidated. In the present study, the antitumor efficacy of α‑solanine against human esophageal carcinoma cells was investigated. It was determined that α‑solanine inhibited the growth and proliferation of human esophageal EC9706 and Eca109 cancer cells in a dose‑dependent manner, as well as the cell migration and invasion. In addition, the apoptotic rate was increased in the cancer cells treated with α‑solanine in a dose‑dependent manner, compared with that of the control group (P<0.05). The expression levels of tumor metastasis‑related proteins, including matrix metalloproteinase (MMP)‑2 and MMP‑9, were reduced in the cells treated with α‑solanine, as compared with the control group. Conversely, significantly higher expression levels of E‑cadherin were detected in the α‑solanine‑treated groups, as compared with the control group (P<0.05). Therefore, the current results provide a novel insight into the anti‑tumor mechanism of α‑solanine, and suggest that α‑solanine is a potential agent for the prevention and treatment of esophageal carcinoma.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Szumiło J: Epidemiology and risk factors of the esophageal squamous cell carcinoma. Pol Merkur Lekarski. 26:82–85. 2009.(In Polish). PubMed/NCBI

3 

Yamashina T, Ishihara R, Nagai K, Matsuura N, Matsui F, Ito T, Fujii M, Yamamoto S, Hanaoka N, Takeuchi Y, et al: Long-term outcome and metastatic risk after endoscopic resection of superficial esophageal squamous cell carcinoma. Am J Gastroenterol. 108:544–551. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Park B, Jun JH, Jung J, You S and Lee MS: Herbal medicines for cancer cachexia: Protocol for a systematic review. BMJ Open. 4:e0050162014. View Article : Google Scholar : PubMed/NCBI

5 

Leng JC and Gany F: Traditional Chinese medicine use among Chinese immigrant cancer patients. J Cancer Educ. 29:56–61. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Friedman M: Potato glycoalkaloids and metabolites: Roles in the plant and in the diet. J Agric Food Chem. 54:8655–8681. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Kuo CI, Chao CH and Lu MK: Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum. Phytochem Anal. 23:400–404. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Friedman M, Lee KR, Kim HJ, Lee IS and Kozukue N: Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma and stomach cancer cells. J Agric Food Chem. 53:6162–6169. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Yang SA, Paek SH, Kozukue N, Lee KR and Kim JA: Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. Food Chem Toxicol. 44:839–846. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lee KR, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS and Friedman M: Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. J Agric Food Chem. 52:2832–2839. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lu MK, Shih YW, Chang Chien TT, Fang LH, Huang HC and Chen PS: α-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities. Biol Pharm Bull. 33:1685–1691. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Lv C, Kong H, Dong G, Liu L, Tong K, Sun H, Chen B, Zhang C and Zhou M: Antitumor efficacy of α-solanine against pancreatic cancer in vitro and in vivo. PLoS One. 9:e878682014. View Article : Google Scholar : PubMed/NCBI

13 

Sun H, Lv C, Yang L, Wang Y, Zhang Q, Yu S, Kong H, Wang M, Xie J, Zhang C and Zhou M: Solanine induces mitochondria-mediated apoptosis in human pancreatic cancer cells. Biomed Res Int. 2014:8059262014. View Article : Google Scholar : PubMed/NCBI

14 

Ji YB, Gao SY, Ji CF and Zou X: Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein. J Ethnopharmacol. 115:194–202. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Lu MK, Chen PH, Shih YW, Chang YT, Huang ET, Liu CR and Chen PS: Alpha-Chaconine inhibits angiogenesis in vitro by reducing matrix metalloproteinase-2. Biol Pharm Bull. 33:622–630. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Gao SY, Wang QJ and Ji YB: Effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells. World J Gastroenterol. 12:3359–3367. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Rosenkranz V and Wink M: Induction of apoptosis by alkaloids. non-protein amino acids and cardiac glycosides in human promyelotic HL-60 cells. Z Naturforsch C. 62:458–466. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Cham BE and Meares HM: Glycoalkaloids from Solanum sodomaeum are effective in the treatment of skin cancers in man. Cancer Lett. 36:111–118. 1987. View Article : Google Scholar : PubMed/NCBI

19 

Yamashoji S and Matsuda T: Synergistic cytotoxicity induced by α-solanine and α-chaconine. Food Chem. 141:669–674. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Friedman M, Henika PR and Mackey BE: Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 41:61–71. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Konstantinidou AE, Korkolopoulou P and Patsouris E: Apoptotic markers for tumor recurrence: A minireview. Apoptosis. 7:461–470. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Yano M, Inoue M and Shiozaki H: Preoperative concurrent chemotherapy and radiation therapy followed by surgery for esophageal cancer. Ann Thorac Cardiovasc Surg. 8:123–130. 2002.PubMed/NCBI

23 

Hsia JY, Chen CY, Hsu CP, Shai SE, Yang SS, Chuang CY, Wang PY and Chen JT: Expression of apoptosis-regulating proteins p53, Bcl-2 and Bax in primary resected esophageal squamous cell carcinoma. Neoplasma. 48:483–488. 2001.PubMed/NCBI

24 

Hunter AM, LaCasse EC and Korneluk RG: The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis. 12:1543–1568. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Kuribayashi K, Mayes PA and El-Deiry WS: What are caspases 3 and 7 doing upstream of the mitochondria? Cancer Biol Ther. 5:763–765. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Vargová V, Pytliak M and Mechírová V: Matrix metalloproteinases. EXS. 103:1–33. 2012.PubMed/NCBI

27 

Pytliak M, Vargová V and Mechírová V: Matrix metalloproteinases and their role in oncogenesis: A review. Onkologie. 35:49–53. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Hofmann UB, Westphal JR, Van Muijen GN and Ruiter DJ: Matrix metalloproteinases in human melanoma. J Invest Dermatol. 115:337–344. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Bauvois B: New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: Outside-in signaling and relationship to tumor progression. Biochim Biophys Acta. 1825:29–36. 2012.PubMed/NCBI

30 

Buda A and Pignatelli M: E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis. Cell Commun Adhes. 18:133–143. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Sun QQ, Zhang SJ, Du YW, Wang YY, Zang WQ, Chen XN and Zhao GQ: Inhibitory effect of α-solanine on esophageal carcinoma in vitro. Exp Ther Med 12: 1525-1530, 2016.
APA
Wang, L., Sun, Q., Zhang, S., Du, Y., Wang, Y., Zang, W. ... Zhao, G. (2016). Inhibitory effect of α-solanine on esophageal carcinoma in vitro. Experimental and Therapeutic Medicine, 12, 1525-1530. https://doi.org/10.3892/etm.2016.3500
MLA
Wang, L., Sun, Q., Zhang, S., Du, Y., Wang, Y., Zang, W., Chen, X., Zhao, G."Inhibitory effect of α-solanine on esophageal carcinoma in vitro". Experimental and Therapeutic Medicine 12.3 (2016): 1525-1530.
Chicago
Wang, L., Sun, Q., Zhang, S., Du, Y., Wang, Y., Zang, W., Chen, X., Zhao, G."Inhibitory effect of α-solanine on esophageal carcinoma in vitro". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1525-1530. https://doi.org/10.3892/etm.2016.3500
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Sun QQ, Zhang SJ, Du YW, Wang YY, Zang WQ, Chen XN and Zhao GQ: Inhibitory effect of α-solanine on esophageal carcinoma in vitro. Exp Ther Med 12: 1525-1530, 2016.
APA
Wang, L., Sun, Q., Zhang, S., Du, Y., Wang, Y., Zang, W. ... Zhao, G. (2016). Inhibitory effect of α-solanine on esophageal carcinoma in vitro. Experimental and Therapeutic Medicine, 12, 1525-1530. https://doi.org/10.3892/etm.2016.3500
MLA
Wang, L., Sun, Q., Zhang, S., Du, Y., Wang, Y., Zang, W., Chen, X., Zhao, G."Inhibitory effect of α-solanine on esophageal carcinoma in vitro". Experimental and Therapeutic Medicine 12.3 (2016): 1525-1530.
Chicago
Wang, L., Sun, Q., Zhang, S., Du, Y., Wang, Y., Zang, W., Chen, X., Zhao, G."Inhibitory effect of α-solanine on esophageal carcinoma in vitro". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1525-1530. https://doi.org/10.3892/etm.2016.3500
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