Inhibitory effect of α-solanine on esophageal carcinoma in vitro

Wang,Lei; Sun,Qian‑Qian; Zhang,Shi‑Jie; Du,Yu‑Wen; Wang,Yuan‑Yuan; Zang,Wen‑Qiao; Chen,Xiao‑Nan; Zhao,Guo‑Qiang

doi:10.3892/etm.2016.3500

Inhibitory effect of α-solanine on esophageal carcinoma in vitro

Authors:
- Lei Wang
- Qian‑Qian Sun
- Shi‑Jie Zhang
- Yu‑Wen Du
- Yuan‑Yuan Wang
- Wen‑Qiao Zang
- Xiao‑Nan Chen
- Guo‑Qiang Zhao
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Affiliations: Department of Emergency, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: July 4, 2016 https://doi.org/10.3892/etm.2016.3500
Pages: 1525-1530

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Abstract

α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in potatoes, has been observed to inhibit growth and induce apoptosis in cancer cells. However, the antitumor efficacy of α‑solanine on esophageal carcinoma has yet to be fully elucidated. In the present study, the antitumor efficacy of α‑solanine against human esophageal carcinoma cells was investigated. It was determined that α‑solanine inhibited the growth and proliferation of human esophageal EC9706 and Eca109 cancer cells in a dose‑dependent manner, as well as the cell migration and invasion. In addition, the apoptotic rate was increased in the cancer cells treated with α‑solanine in a dose‑dependent manner, compared with that of the control group (P<0.05). The expression levels of tumor metastasis‑related proteins, including matrix metalloproteinase (MMP)‑2 and MMP‑9, were reduced in the cells treated with α‑solanine, as compared with the control group. Conversely, significantly higher expression levels of E‑cadherin were detected in the α‑solanine‑treated groups, as compared with the control group (P<0.05). Therefore, the current results provide a novel insight into the anti‑tumor mechanism of α‑solanine, and suggest that α‑solanine is a potential agent for the prevention and treatment of esophageal carcinoma.

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