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Article

Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain

  • Authors:
    • Jian Sun
    • Xiao‑Ling Chen
    • Jin‑Yu Zheng
    • Jian‑Wei Zhou
    • Zheng‑Liang Ma
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, Jiangsu 223002, P.R. China, Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, Jiangsu 223003, P.R. China, Department of Anesthesiology, Drum Tower Clinical Medical School, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 1829-1835
    |
    Published online on: July 13, 2016
       https://doi.org/10.3892/etm.2016.3519
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Abstract

Exposure to general anesthesia may cause severe neurotoxicity in developing brain due to neuronal apoptosis. Astragaloside IV (AS IV) has antioxidant and antiapoptosis properties; however, its effects on anesthesia-induced neuroapoptosis have not been studied. In the present study, we determined whether AS IV pre‑treatment is able to reduce isoflurane exposure‑induced neuroapoptosis in rats. New born rats were pre‑treated with AS IV or solvent by oral gavage for three days, then exposed to isoflurane. The results showed that pre‑treatment of AS IV significantly inhibited isoflurane‑induced neural apoptosis in the hippocampus of new born rats, and such protection was accompanied by reduced levels of caspase‑3, nuclear factor‑κB activation and phosphorylated c‑Jun N-terminal kinase, extracellular signal–regulated kinase and increased levels of B‑cell lymphoma-2, glycogen synthase kinase‑3β, Klotho and phosphorylated protein kinase B. Furthermore, AS IV pre‑treatment significantly alleviated isoflurane‑induced oxidative stress and proinflammatory cytokine release in the rat hippocampus and serum. In summery, the results of the study demonstrated that AS IV is able to protect developing brain from anesthesia‑induced neuroapoptosis via anti‑oxidant and anti-inflammatory activities.
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1 

Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, Tenkova TI, Stefovska V, Turski L and Olney JW: Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science. 283:70–74. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Hörster F, Tenkova T, et al: Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science. 287:1056–1060. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW and Wozniak DF: Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci. 23:876–882. 2003.PubMed/NCBI

4 

Dobbing J and Sands J: Comparative aspects of the brain growth spurt. Early Hum Dev. 3:79–83. 1979. View Article : Google Scholar : PubMed/NCBI

5 

Felderhoff-Mueser U and Ikonomidou C: Mechanisms of neurodegeneration after paediatric brain injury. Curr Opin Neurol. 13:141–145. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Fredriksson A, Pontén E, Gordh T and Eriksson P: Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology. 107:427–436. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Wilder RT, Flick RP, Sprung J, Katusic SK, Barbaresi WJ, Mickelson C, Gleich SJ, Schroeder DR, Weaver AL and Warner DO: Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology. 110:796–804. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Servick K: Biomedical Research. Researchers struggle to gauge risks of childhood anesthesia. Science. 346:1161–1162. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Olney JW, Ishimaru MJ, Bittigau P and Ikonomidou C: Ethanol-induced apoptotic neurodegeneration in the developing brain. Apoptosis. 5:515–521. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Renault TT, Floros KV, Elkholi R, Corrigan KA, Kushnareva Y, Wieder SY, Lindtner C, Serasinghe MN, Asciolla JJ, Buettner C, et al: Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. Mol Cell. 57:69–82. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Yin H and Zhu M: Free radical oxidation of cardiolipin: Chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases. Free Radic Res. 46:959–974. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Jawaid P, ur Rehman M, Yoshihisa Y, Li P, Zhao Ql, Hassan MA, Miyamoto Y, Shimizu T and Kondo T: Effects of SOD/catalase mimetic platinum nanoparticles on radiation-induced apoptosis in human lymphoma U937 cells. Apoptosis. 19:1006–1016. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Li M, Wang W, Xue J, Gu Y and Lin S: Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol. 133:412–419. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Matkovic Z, Zivkovic V, Korica M, Plavec D, Pecanic S and Tudoric N: Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res. 24:175–181. 2010.PubMed/NCBI

15 

Qu YZ, Li M, Zhao YL, Zhao ZW, Wei XY, Liu JP, Gao L and Gao GD: Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. Eur J Pharmacol. 606:137–141. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Li M, Ma RN, Li LH, Qu YZ and Gao GD: Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4. Eur J Pharmacol. 715:189–195. 2013. View Article : Google Scholar : PubMed/NCBI

17 

He Y, Du M, Gao Y, Liu H, Wang H, Wu X and Wang Z: Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels. PLoS One. 8:e764952013. View Article : Google Scholar : PubMed/NCBI

18 

Gui D, Huang J, Guo Y, Chen J, Chen Y, Xiao W, Liu X and Wang N: Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression. Cytokine. 61:970–977. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Ding Y, Yuan S, Liu X, Mao P, Zhao C, Huang Q, Zhang R, Fang Y, Song Q, Yuan D, et al: Protective effects of astragaloside IV on db/db mice with diabetic retinopathy. PLoS One. 9:e1122072014. View Article : Google Scholar : PubMed/NCBI

20 

Xu W, Shao X, Tian L, Gu L, Zhang M, Wang Q, Wu B, Wang L, Yao J, Xu X, et al: Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp Ther. 350:552–562. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Zhang ZG, Wu L, Wang JL, Yang JD, Zhang J, Zhang J, Li LH, Xia Y, Yao LB, Qin HZ and Gao GD: Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production. Mol Cell Biochem. 364:209–216. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Sun Q, Jia N, Wang W, Jin H, Xu J and Hu H: Protective effects of astragaloside IV against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening. PLoS One. 9:e988662014. View Article : Google Scholar : PubMed/NCBI

23 

Miloso M, Scuteri A, Foudah D and Tredici G: MAPKs as mediators of cell fate determination: An approach to neurodegenerative diseases. Curr Med Chem. 15:538–548. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Friedlander RM: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med. 348:1365–1375. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Yang H, Liang G, Hawkins BJ, Madesh M, Pierwola A and Wei H: Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies. Anesthesiology. 109:243–250. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Blaylock M, Engelhardt T and Bissonnette B: Fundamentals of neuronal apoptosis relevant to pediatric anesthesia. Paediatr Anaesth. 20:383–395. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Skowrońska M and Albrecht J: Oxidative and nitrosative stress in ammonia neurotoxicity. Neurochem Int. 62:731–737. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Karin M and Lin A: NF-kappaB at the crossroads of life and death. Nat Immunol. 3:221–227. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Mincheva-Tasheva S and Soler RM: NF-κB signaling pathways: Role in nervous system physiology and pathology. Neuroscientist. 19:175–194. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Sanders RD, Sun P, Patel S, Li M, Maze M and Ma D: Dexmedetomidine provides cortical neuroprotection: Impact on anaesthetic-induced neuroapoptosis in the rat developing brain. Acta Anaesthesiol Scand. 54:710–716. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Shao A, Guo S, Tu S, Ammar AB, Tang J, Hong Y, Wu H and Zhang J: Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats. Int J Med Sci. 11:1073–1081. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu JH, Zhang WD and Chen J: Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett. 363:218–223. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun J, Chen XL, Zheng JY, Zhou JW and Ma ZL: Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain. Exp Ther Med 12: 1829-1835, 2016.
APA
Sun, J., Chen, X., Zheng, J., Zhou, J., & Ma, Z. (2016). Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain. Experimental and Therapeutic Medicine, 12, 1829-1835. https://doi.org/10.3892/etm.2016.3519
MLA
Sun, J., Chen, X., Zheng, J., Zhou, J., Ma, Z."Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain". Experimental and Therapeutic Medicine 12.3 (2016): 1829-1835.
Chicago
Sun, J., Chen, X., Zheng, J., Zhou, J., Ma, Z."Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1829-1835. https://doi.org/10.3892/etm.2016.3519
Copy and paste a formatted citation
x
Spandidos Publications style
Sun J, Chen XL, Zheng JY, Zhou JW and Ma ZL: Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain. Exp Ther Med 12: 1829-1835, 2016.
APA
Sun, J., Chen, X., Zheng, J., Zhou, J., & Ma, Z. (2016). Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain. Experimental and Therapeutic Medicine, 12, 1829-1835. https://doi.org/10.3892/etm.2016.3519
MLA
Sun, J., Chen, X., Zheng, J., Zhou, J., Ma, Z."Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain". Experimental and Therapeutic Medicine 12.3 (2016): 1829-1835.
Chicago
Sun, J., Chen, X., Zheng, J., Zhou, J., Ma, Z."Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1829-1835. https://doi.org/10.3892/etm.2016.3519
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