Open Access

Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant

  • Authors:
    • Alina Tanase
    • Anca Colita
    • Gabriel Ianosi
    • Daniela Neagoe
    • Daciana Elena Branisteanu
    • Daniela Calina
    • Anca Oana Docea
    • Aristidis Tsatsakis
    • Simona Laura Ianosi
  • View Affiliations

  • Published online on: August 1, 2016     https://doi.org/10.3892/etm.2016.3562
  • Pages: 2078-2082
  • Copyright: © Tanase et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft‑vs.‑host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease. On day 330 after transplant the patient presented with fever and several painful subcutaneous, tender, red nodules with ulcerative and necrotic features on the pelvic region and right leg, extensive glass infiltrative lesions in the lungs and pansinusitis; however, the patient did not have onychomycosis. Following skin biopsy, culture of cutaneous lesions, computed tomography (CT) scanning of the lungs and CT scanning and magnetic resonance imaging of facial sinuses the patient was diagnosed with disseminated Fusarium species infection. Despite intensive treatment with voriconazole, the patient succumbed with respiratory insufficiency on day 400 after transplant. This case is noteworthy because the patient did not have any additional risk associated with the allogeneic transplant; there was no transplant mismatch, no severe neutropenia and no prior clinical signs of onychomycosis. The association of skin lesions with GVHD lesions increased the initial immunosuppression and delayed diagnosis.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tanase A, Colita A, Ianosi G, Neagoe D, Branisteanu DE, Calina D, Docea AO, Tsatsakis A and Ianosi SL: Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. Exp Ther Med 12: 2078-2082, 2016
APA
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D.E., Calina, D. ... Ianosi, S.L. (2016). Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. Experimental and Therapeutic Medicine, 12, 2078-2082. https://doi.org/10.3892/etm.2016.3562
MLA
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D. E., Calina, D., Docea, A. O., Tsatsakis, A., Ianosi, S. L."Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant". Experimental and Therapeutic Medicine 12.4 (2016): 2078-2082.
Chicago
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D. E., Calina, D., Docea, A. O., Tsatsakis, A., Ianosi, S. L."Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2078-2082. https://doi.org/10.3892/etm.2016.3562