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Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant

  • Authors:
    • Alina Tanase
    • Anca Colita
    • Gabriel Ianosi
    • Daniela Neagoe
    • Daciana Elena Branisteanu
    • Daniela Calina
    • Anca Oana Docea
    • Aristidis Tsatsakis
    • Simona Laura Ianosi
  • View Affiliations / Copyright

    Affiliations: Bone Marrow Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania, Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Dermatology, University of Medicine and Pharmacy ‘Gr. T. Popa’, 700115 Iasi, Romania, Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion 71409, Greece, Department of Dermatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
    Copyright: © Tanase et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2078-2082
    |
    Published online on: August 1, 2016
       https://doi.org/10.3892/etm.2016.3562
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Abstract

Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft‑vs.‑host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease. On day 330 after transplant the patient presented with fever and several painful subcutaneous, tender, red nodules with ulcerative and necrotic features on the pelvic region and right leg, extensive glass infiltrative lesions in the lungs and pansinusitis; however, the patient did not have onychomycosis. Following skin biopsy, culture of cutaneous lesions, computed tomography (CT) scanning of the lungs and CT scanning and magnetic resonance imaging of facial sinuses the patient was diagnosed with disseminated Fusarium species infection. Despite intensive treatment with voriconazole, the patient succumbed with respiratory insufficiency on day 400 after transplant. This case is noteworthy because the patient did not have any additional risk associated with the allogeneic transplant; there was no transplant mismatch, no severe neutropenia and no prior clinical signs of onychomycosis. The association of skin lesions with GVHD lesions increased the initial immunosuppression and delayed diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Tanase A, Colita A, Ianosi G, Neagoe D, Branisteanu DE, Calina D, Docea AO, Tsatsakis A and Ianosi SL: Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. Exp Ther Med 12: 2078-2082, 2016.
APA
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D.E., Calina, D. ... Ianosi, S.L. (2016). Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. Experimental and Therapeutic Medicine, 12, 2078-2082. https://doi.org/10.3892/etm.2016.3562
MLA
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D. E., Calina, D., Docea, A. O., Tsatsakis, A., Ianosi, S. L."Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant". Experimental and Therapeutic Medicine 12.4 (2016): 2078-2082.
Chicago
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D. E., Calina, D., Docea, A. O., Tsatsakis, A., Ianosi, S. L."Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2078-2082. https://doi.org/10.3892/etm.2016.3562
Copy and paste a formatted citation
x
Spandidos Publications style
Tanase A, Colita A, Ianosi G, Neagoe D, Branisteanu DE, Calina D, Docea AO, Tsatsakis A and Ianosi SL: Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. Exp Ther Med 12: 2078-2082, 2016.
APA
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D.E., Calina, D. ... Ianosi, S.L. (2016). Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant. Experimental and Therapeutic Medicine, 12, 2078-2082. https://doi.org/10.3892/etm.2016.3562
MLA
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D. E., Calina, D., Docea, A. O., Tsatsakis, A., Ianosi, S. L."Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant". Experimental and Therapeutic Medicine 12.4 (2016): 2078-2082.
Chicago
Tanase, A., Colita, A., Ianosi, G., Neagoe, D., Branisteanu, D. E., Calina, D., Docea, A. O., Tsatsakis, A., Ianosi, S. L."Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2078-2082. https://doi.org/10.3892/etm.2016.3562
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