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Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage

  • Authors:
    • Ye Xiong
    • Xue‑Min Wang
    • Ming Zhong
    • Ze‑Qun Li
    • Zhi Wang
    • Zuo‑Fu Tian
    • Kuang Zheng
    • Xian‑Xi Tan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1993-2002
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    Published online on: August 4, 2016
       https://doi.org/10.3892/etm.2016.3568
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Abstract

The aim of the present study was to evaluate the expression levels of caveolin-1 in the basilar artery following delayed cerebral vasospasm (DCVS) in a rat model of subarachnoid hemorrhage (SAH), in order to investigate the association between caveolin‑1 and DCVS, and its potential as a treatment for DCVS of SAH. A total of 150 Sprague Dawley rats were randomly allocated into blank, saline and SAH groups. The SAH and saline groups were subdivided into days 3, 5, 7 and 14 following the establishment of the model. The murine model of SAH was established by double injection of autologous arterial blood into the cisterna magana and DCVS was detected using Bederson neurological severity scores. Hematoxylin and eosin (HE) staining was used to observe the inner perimeter of the basilar artery pipe and variations in the thickness of the basilar artery wall. Alterations in the levels of caveolin‑1 protein in the basilar artery were measured using immunofluorescence and western blot analysis; whereas alterations in the mRNA expression levels of caveolin‑1 were detected by reverse transcription‑quantitative polymerase chain reaction. In the present study, 15 mice succumbed to SAH‑induced DCVS in the day 3 (n=3), 5 (n=5) and 7 (n=2) groups. No mortality was observed in the blank control and saline groups during the process of observation in the SAH group, All mice in the SAH groups exhibited Bederson neurological severity scores ≥1; whereas no neurological impairment was detected in the blank and normal saline groups, demonstrating the success of the model. HE staining was used to assess vasospasm and the results demonstrated that the inner perimeter of the basal artery pipe decreased at day 3 in the SAH group; whereas values peaked in the day 7 group. The thickness of the basal artery wall significantly increased (P<0.05), as compared with the blank and saline groups, in which no significant alterations in the wall thickness and the inner perimeter of the basal artery pipe were detected. As detected by immunofluorescence and western blot analysis, the expression levels of caveolin‑1 protein significantly decreased in the day 7 of SAH group, as compared with the blank and saline groups (P<0.01), in which no significant alterations were detected. Caveolin‑1 mRNA expression levels significantly increased at the day 7 in the SAH group, as compared with the blank and the saline groups (P<0.01), as detected by RT‑qPCR. Furthermore, significant differences were detected at day 14 in the SAH group, as compared with the blank and the saline groups (P>0.05), in which no significant alterations were detected. Therefore, the results of the present study demonstrated that caveolin‑1 protein was downregulated in the basilar artery of a rat modeling SAH, which may be associated with DCVS. This suggested that caveolin‑1 may be a potential target for the treatment of DCVS.
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View References

1 

Wencel K, Dyaczyńska-Herman A and Wencel T: Plasma clotting and fibrinolysis parameters in patients with spontaneous and posttraumatic SAH. Clin Neuro Neurosurg. 99(Suppl 1): 70. 1997. View Article : Google Scholar

2 

Arreche ND, Sarati LI, Martinez CR, Fellet AL and Balaszczuk AM: Contribution of caveolin-1 to ventricular nitric oxide in age-related adaptation to hypovolemic state. Regul Pept. 179:43–49. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Agyemang C, van Oeffelen AA, Norredam M, et al: Ethnic disparities in ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage incidence in The Netherlands. Stroke. 45:3236–3242. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Laskowitz DT and Kolls BJ: Neuroprotection in subarachnoid hemorrhage. Stroke. 41(Suppl 10): S79–S84. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, et al: Guidelines for the management of aneurysmal subarachnoid hemorrhage: A guideline for healthcare professionals from the American heart association/American stroke association. Stroke. 43:1711–1737. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Pluta RM: Introduction to problems of postsubarachnoid hemorrhage delayed cerebral vasospasmAnimal Models of Acute Neurological Injuries II. Humana Press; New York, NY: pp. 459–464. 2012, View Article : Google Scholar

7 

Anderson GB, Ashforth R, Steinke DE, et al: CT angiography for the detection of cerebral vasospasm in patients with acute subarachnoid hemorrhage. Am J Neuroradiol. 21:1011–1015. 2000.PubMed/NCBI

8 

Specogna AV: Subarachnoid hemorrhage diagnosis. JAMA. 311:2012014. View Article : Google Scholar : PubMed/NCBI

9 

Huang W and Zhou Z: Research advances on pathogenesy of cerebral vasospasm after suharachnoid hemorrhage. Zhong Guo Nao Xue Guan Bing Za Zhi. 7:215–219. 2010.(In Chinese).

10 

Roos YB, Dijkgraaf MG, Albrecht KW, Beenen LF, Groen RJ, de Haan RJ and Vermeulen M: Direct costs of modern treatment of aneurysmal subarachnoid hemorrhage in the first year after diagnosis. Stroke. 33:1595–1599. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Pluta RM: Delayed cerebral vasospasm and nitric oxide: Review, new hypothesis, and proposed treatment. Pharmacol Ther. 05:23–56. 2005. View Article : Google Scholar

12 

Suzuki H, Kanamaru K, Tsunoda H, Inada H, Kuroki M, Sun H, Waga S and Tanaka T: Heme oxygenase-1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats. J Clin Invest. 104:59–66. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Varsos VG, Liszczak TM, Han DH, Kistler JP, Vielma J, Black PM, Heros RC and Zervas NT: Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a ‘two-hemorrhage’ canine model. J Neurosurg. 58:11–17. 1983. View Article : Google Scholar : PubMed/NCBI

14 

Manabe K, Ito H, Matsuda H, et al: Hyperpolarization induced by vasoactive substances in intact guinea-pig endocardial endothelial cells. J Physiol. 484:25–40. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Rabinstein AA, Lanzino G and Wijdicks EF: Multidisciplinary management and emerging therapeutic strategies in aneurysmal subarachnoid haemorrhage. Lancet Neurol. 9:504–519. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Rothberg KG, Heuser JE, Donzell WC, Ying YS, Glenney JR and Anderson RG: Caveolin, a protein component of caveolae membrane coats. Cell. 68:673–82. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Zhang H and Zou W: Caveolin-1 and Breast Cancer. Chinese Zhong Guo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao. 23:20–26. 2007.(In Chinese).

18 

Sampson MJ, Lovell RS and Craigen WJ: The murine voltage-dependent anion channel gene family. Conserved structure and function. J Biol Chem. 272:18966–18973. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M, Parkinson EK and Black DM: Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene. 18:1881–1890. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Prinetti A, Prioni S, Loberto N, Aureli M, Chigorno V and Sonnino S: Regulation of tumor phenotypes by caveolin-1 and sphingolipid-controlled membrane signaling complexes. Biochim Biophys Acta. 1780:585–596. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Botos E, Klumperman J, Oorschot V, Igyártó B, Magyar A, Oláh M and Kiss AL: Caveolin-1 is transported to multi-vesicular bodies after albumin-induced endocytosis of caveolae in HepG2 cells. J Cell Mol Med. 12:1632–1639. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Arakawa R, Abedohmae S, Asai M, Ito JI and Yokoyama S: Involvement of caveolin-1 in cholesterol enrichment of high density lipoprotein during its assembly by apolipoprotein and THP-1 cells. J Lipid Res. 41:1952–1962. 2001.

23 

Yu Q, Chen X, Fang X, Chen Q and Hu C: Caveolin-1 aggravates cigarette smoke extract-induced MUC5AC secretion in human airway epithelial cells. Int J Mol Med. 35:1435–1442. 2015.PubMed/NCBI

24 

Smart EJ, Graf GA, McNiven MA, Sessa WC, Engelman JA, Scherer PE, Okamoto T and Lisanti MP: Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol. 19:7289–7304. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Song L, Liu J, Zou W and An LJ: Role of Caveolin-1 in cell senescence and senescent dieases. Zhong Guo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao. 08:712–720. 2011.(In Chinese).

26 

Jasmin JF, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum DM and Lisanti MP: Caveolin-1 deficiency increases cerebral ischemic injury. Circ Res. 100:721–729. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Shen J, Ma S, Chan P, Lee W, Fung PC, Cheung RT, Tong Y and Liu KJ: Nitric and oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. J Neurochem. 96:1078–1089. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Lee JY, Huang DL, Keep R and Sagher O: Characterization of an improved double hemorrhage rat model for the study of delayed cerebral vasospasm. J Neurosci Methods. 168:358–366. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL and Bartkowski H: Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination. Stroke. 17:472–476. 1986. View Article : Google Scholar : PubMed/NCBI

30 

Vellimana AK, Milner E, Azad TD, Harries MD, Zhou ML, Gidday JM, Han BH and Zipfel GJ: Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm. Stroke. 42:776–782. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Kassell NF, Sasaki T, Colohan AR and Nazar G: Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke. 1985.16:562–572. 1985. View Article : Google Scholar : PubMed/NCBI

32 

Jia L and Sun BL: Establishment of an animal model of cerebral vasospasm following subarachnoid hemorrhage. J Clinical Rehabilitative Tissue Engineering Research. 13:8147–8150. 2009.

33 

Sugawara T, Ayer R, Jadhav V and Zhang JH: A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 167:327–334. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Marbacher S, Fandino J and Kitchen ND: Standard intracranial in vivo animal models of delayed cerebral vasospasm. Br J Neurosurg. 24:415–434. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Güresir E, Raabe A, Jaiimsin A, Dias S, Raab P, Seifert V and Vatter H: Histological evidence of delayed ischemic brain tissue damage in the rat double-hemorrhage model. J Neurol Sci. 293:18–22. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Yanamoto H, Kataoka H, Nakajo Y and Iihara K: The role of the host defense system in the development of cerebral vasospasm: Analogies between atherosclerosis and subarachnoid hemorrhage. Eur Neurol. 68:329–343. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Chaichana KL, Pradilla G, Huang J and Tamargo RJ: Role of inflammation (leukocyte-endothelial cell interactions) in vasospasm after subarachnoid hemorrhage. World Neurosurg. 73:22–41. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Anuntasethakul T, Srikiatkhachorn A, Maneesri S, Patumraj S and Kasantikul V: Ultrastructural changes in endothelial cells of cerebral microvessels after exposure to nitric oxide donor. Neuropathol. 19:259–266. 1999. View Article : Google Scholar

39 

Pluta RM, Andre D, George G, Gladwin MT and Oldfield EH: Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA. 293:1477–1484. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Kevil CG and Patel RP: Preserving vessel function during ischemic disease: New possibilities of inorganic nitrite therapy. Expert Rev Cardiovasc Ther. 6:1175–1179. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Duncan C, Dougall H, Johnston P, Green S, Brogan R, Leifert C, Smith L, Golden M and Benjamin N: Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1:546–551. 1995. View Article : Google Scholar : PubMed/NCBI

42 

Dora KA, Doyle MP and Duling BR: Elevation of intracellular calcium in smooth muscle causes endothelial cell generation of NO in arterioles. PNAS. 94:6529–6534. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Corpas FJ, Barroso JB, Carreras A, Quirós M, León AM, Romero-Puertas MC, Esteban FJ, Valderrama R, Palma JM, Sandalio LM, et al: Cellular and subcellular localization of endogenous nitric oxide in young and senescent pea plants. Plant Physiol. 136:2722–2733. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Russell FD and Molenaar P: The human heart endothelin system: ET-1 synthesis, storage, release and effect. Trends Pharmacol Sci. 21:353–359. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Thyberg J: Caveolin-1 and caveolae act as regulators of mitogenic signaling in vascular smooth muscle cells. Arterioscler Thrombo Vasc Biol. 23:1481–1483. 2003. View Article : Google Scholar

46 

Penumathsa SV, Koneru S, Samuel SM, Maulik G, Bagchi D, Yet SF, Menon VP and Maulik N: Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: role of caveolin-1, eNOS, HO-1 and VEGF. Free Radic Biol Med. 45:1027–1034. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Zhang X, Zhou Z, Liu J, Feng B, Zhang J and Huang W: Relationship between caveolin-1 and proliferation of basilar artery smooth muscle in rabbit model of subarachnoid hemorrhage. Journal of Third Military Medical University. 33:830–834. 2011.

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Copy and paste a formatted citation
Spandidos Publications style
Xiong Y, Wang XM, Zhong M, Li ZQ, Wang Z, Tian ZF, Zheng K and Tan XX: Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage. Exp Ther Med 12: 1993-2002, 2016.
APA
Xiong, Y., Wang, X., Zhong, M., Li, Z., Wang, Z., Tian, Z. ... Tan, X. (2016). Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage. Experimental and Therapeutic Medicine, 12, 1993-2002. https://doi.org/10.3892/etm.2016.3568
MLA
Xiong, Y., Wang, X., Zhong, M., Li, Z., Wang, Z., Tian, Z., Zheng, K., Tan, X."Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage". Experimental and Therapeutic Medicine 12.4 (2016): 1993-2002.
Chicago
Xiong, Y., Wang, X., Zhong, M., Li, Z., Wang, Z., Tian, Z., Zheng, K., Tan, X."Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage". Experimental and Therapeutic Medicine 12, no. 4 (2016): 1993-2002. https://doi.org/10.3892/etm.2016.3568
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong Y, Wang XM, Zhong M, Li ZQ, Wang Z, Tian ZF, Zheng K and Tan XX: Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage. Exp Ther Med 12: 1993-2002, 2016.
APA
Xiong, Y., Wang, X., Zhong, M., Li, Z., Wang, Z., Tian, Z. ... Tan, X. (2016). Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage. Experimental and Therapeutic Medicine, 12, 1993-2002. https://doi.org/10.3892/etm.2016.3568
MLA
Xiong, Y., Wang, X., Zhong, M., Li, Z., Wang, Z., Tian, Z., Zheng, K., Tan, X."Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage". Experimental and Therapeutic Medicine 12.4 (2016): 1993-2002.
Chicago
Xiong, Y., Wang, X., Zhong, M., Li, Z., Wang, Z., Tian, Z., Zheng, K., Tan, X."Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage". Experimental and Therapeutic Medicine 12, no. 4 (2016): 1993-2002. https://doi.org/10.3892/etm.2016.3568
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